Terminology Service for NFDI4Health
All terms in BAO
| Label | Id | Description |
|---|---|---|
| indicator | CHEBI_47867 | |
| percent inhibition normalization | BAO_0000065 | [Data normalization obtained by dividing the difference of mean of the positive controls and sample measurement by the difference of the mean of the positive controls and mean of the negative control.] |
| normalization based on control | BAO_0002750 | [Raw sample measurements are normalized relative to positive and negative control samples with known activity and inactivity. Endpoints are usually expressed as percentage, which include percent activity, percent inhibition, etc.] |
| total internal reflection fluorescence microscopy | BAO_0000064 | [This technique probes the surface of fluorescently-labeled living cells with an evanescent wave generated by a light beam traveling between two media of differing refractive indices. An incident laser beam is reflected at a critical angle (total internal reflection) when it encounters the interface between a microscope glass slide and the aqueous medium containing the cells. Only fluorophores which are within a few nanometers of the surface are excited, while those farther away are not, making possible the study the interactions at the cell surface.] |
| voltage clamp | BAO_0000063 | [The voltage clamp technique is used to measure the ion currents across an excitable cell membrane, such as neuronal membrane, while holding the membrane voltage at a constant level. The neuronal membrane contains different kinds of ion channels including voltage gated ion channels. Manipulation of the membrane voltage using voltage clamping allows the current-voltage relationships of these ion channels to be studied.] |
| microelectrode measurement | BAO_0000382 | [Electrically active cells, such as neurons, muscle and endocrine cells undergo changes in membrane potential due to depolarization and hyperpolarization as a result of opening and closing of ion channels. The electrical recordings from these cells are obtained by the insertion or attaching microelectrodes to these cells. Patch clamp, voltage clamp and current clamp are three ways of studying the current-voltage relationships of these ion channels.] |
| patch clamp | BAO_0000062 | [The patch clamping technique is refined from the voltage clamp technique, wherein a blunt electrode is placed on the surface of the cell membrane. It is a common intracellular recording technique in electrophysiology that allows either the measurement of current passing through individual ion channels in cells or through whole cells. Suction is applied via the blunt electrode (glass pipette in classical patch clamp technique) to create a high resistance (gigaohm) between the electrode and cell surface. This seal isolates the ion channels within the patch from the rest of the membrane and allows the neurophysiologist to record only from these ion channels.] |
| probe | CHEBI_50406 | |
| protein dephosphorylation | GO_0006470 | [The process of removing one or more phosphoric residues from a protein.] |
| positive control | BAO_0000080 | [The role of a chemical compound or reagent used in each plate of an assay to normalize the response of the test perturbagens (by plate). Compounds that can have a positive control role are known from previous experiments or is a previously established standard. It is usually highly active resulting in a strong response of the intended effect. In an inhibition assay the positive control would usually result in the complete inhibition, which is then used for normalization (i.e. set as 100%). In an activation assay it would be activator used to normalize activity. Using controls provides an external reference and reduces the number of false negatives and false positives.] |
| acute hemorrhagic leukoencephalitis | DOID_10992 | [A very rare form of acute disseminated encephalomyelitis, characterized by a brief but intense attack of inflammation and necrotizing vasculitis of venules and hemorrhage, and edema.] |
| acute disseminated encephalomyelitis | DOID_639 | [An encephalomyelitis characterized by inflammation located_in brain and located_in spinal cord that damages myelin. It usually occurs after viral infection, but also following vaccination, bacterial or parasitic infection.] |
| fungicide | CHEBI_24127 | |
| antifungal agent | CHEBI_35718 | |
| pesticide | CHEBI_25944 | |
| gallbladder melanoma | DOID_8167 | |
| melanoma | DOID_1909 | [A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye.] |
| gallbladder cancer | DOID_3121 | [A biliary tract cancer that is located_in the gallbladder.] |
| negative control | BAO_0000079 | [ It is the role played by the solvent (e.g. DMSO) in which the perturbagen was dissolved. The negative control is used to determine the base-line to compare the effect of the test perturbagen.] |
| unit of measurement | BAO_0000077 | [It is the definite magnitude of a physical quantity or of time. It has a quantity and a unit associated with it.] |