Terminology Service < Semantic Lookup Platform

All terms in BAO

Label	Id	Description
immunolabeling method	BAO_0002425	[Immunolabeling is a means of localizing particular antigens within tissue. Immunolabeling is a methodological process where: 1) antibodies are used to identify antigens within an organism and 2) a tag (e.g. through fluorescence, gold beads, epitope tag, etc.) is added to a secondary antibody which binds to the primary antibody.]
nucleic acid sequencing method	BAO_0002447
cell fixation method	BAO_0002035
vertebrate	BAO_0000510	[This includes animals having a vertebral column, and model organisms from this group include the zebrafish, mouse, rat, etc]
recombinant expression	BAO_0000360	[This involves cloning the cDNA of the gene of interest in a plasmid or viral vector and introducing it into a bacterial, insect or mammalian cell for expression. The expressed protein is then purified after lysing the cells followed by a series of centrifugation and, or chromatography and electrophoresis methods.]
rectal prolapse	DOID_9307
rectal disease	DOID_1285
G protein	BAO_0000368	[There are two distinct G protein families, namely the heterotrimeric G proteins (consisting of the α, β and γ subunits) downstream of the G protein coupled receptors (GPCRs) and the monomeric G proteins that belong to the Ras superfamily of GTPases. Upon ligand binding, the GPCR undergoes a conformational change, which allows it to act as a guanine nucleotide exchange factor (GEF) of an associated G protein. The GTP-bound G α subunit then signals by regulating the activity of adenylate cyclase, phospholipase, or Rho GEFs. ]
membrane protein	BAO_0000367	[Membrane proteins are associated with the cell membrane. They can be classified into two broad categories]
DLD-1 cell	CLO_0002785
microscope	BAO_0150008
optical microscope	BAO_0150009
leukodystrophy	DOID_10579	[A cerebral degeneration characterized by dysfunction of the white matter of the brain.]
membrane potential measurement method	BAO_0000377	[All living cells maintain a resting membrane potential, which is the difference in voltage between the interior and exterior of the cell. Electrically active cells, such as neurons, muscle and endocrine cells undergo changes in membrane potential due to depolarization and hyperpolarization as a result of opening and closing of ion channels. Action potentials are large and rapid changes in membrane potential which are generated as a result of a large depolarization event. In neurons, action potentials are used to transmit signals across neurons, while in muscle and endocrine cells, they lead to intracellular events, such as muscle contraction and hormone release, respectively. In addition, mitochondria possess a trans-membrane potential as a result of their respiratory function. Membrane potential can be measured either by using electrophysiological techniques or by staining with dyes whose binding is dependent on the membrane potential.]
fold inhibition	BAO_0000376	[The ratio of biological activity in the absence of an exogenous substance to that in its presence. This result type is used exclusively with single point (screening concentration) assays.]
fold activation	BAO_0000375	[The ratio of biological activity in the presence of an exogenous substance to that in its absence. This result type is used exclusively with single point (screening concentration) assays.]
heterogeneous phase	BAO_0000373	[One or more assay components are present in solid phase at time of detection. (e.g.: cells, beads).]
assay phase characteristic	BAO_0000371	[It refers to whether all the assay components are in solution or some are in solid phase, which determines their ability to scatter light.]
homogeneous phase	BAO_0000372	[All assay components exist in solution phase at the time of detection (e.g. none of the components are in beads or cells). Technically no component scatters light.]
CellWoRx HCS Reader	BAO_0150002