Terminology Service < Semantic Lookup Platform

All terms in BAO

Label	Id	Description
renal agenesis	DOID_14766	[A renal disease that is characterized by the failure of one or both kidneys to develop.]
assay measurement type	BAO_0000409	[This describes whether a change in an assay is measured once at one fixed end-point or over a period of time at several time points.]
lysate based	BAO_0000408	[This assay is performed to study interaction between a radio-labeled ligand and the receptor in presence of cold ligand. The cells exposed to the radioligand and cold ligand are washed to remove the unbound ligands. They are then lysed and the bound radioactivity is counted in a liquid scintillation counter.]
calcaneonavicular coalition	DOID_14762	[A synostosis characterized by the fusion of carpal and tarsal bones, which causes stiffness and immobility of the hands and the feet.]
synostosis	DOID_11971	[A dysostosis that results_in abnormal fusing of adjacent bones.]
avian influenza	DOID_4492	[An influenza that results_in infection located_in respiratory tract of humans, domestic and wild birds, has_material_basis_in Influenza A virus, which is transmitted_by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has_symptom fever, has_symptom cough, has_symptom sore throat, has_symptom muscle aches, has_symptom nausea, has_symptom diarrhea, has_symptom vomiting, has_symptom neurologic changes, has_symptom pneumonia, and has_symptom acute respiratory distress.]
influenza	DOID_8469	[A viral infectious disease that results_in infection, located_in respiratory tract, has_material_basis_in Influenzavirus A, has_material_basis_in Influenzavirus B, or has_material_basis_in Influenzavirus C, which are transmitted_by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. It is a highly contagious disease that affects birds and mammals and has_symptom chills, has_symptom fever, has_symptom sore throat, has_symptom runny nose, has_symptom muscle pains, has_symptom severe headache, has_symptom cough, and has_symptom weakness.]
integumentary system benign neoplasm	DOID_0060121	[An organ system benign neoplasm located_in the integumentary system organs.]
multi parameter readout	BAO_0000407	[This is typically performed in HCS, where multiple parameters are measured simultaneously from a single cell / well, by the detection of several fluorescent labels. E.g., neurite length, nuclear size, protein translocation, etc.]
measure group specification	BAO_0002185	[An abstract concept to group one or more assay readout and allow description of an assay that measures one or more effect of a perturbagen on the biological entity. This does not define the physical readout method itself, which is captured in assay design, but rather classifies the data being generated by those readouts.]
squamous cell neoplasm	DOID_3168	[A cell type benign neoplasm composed_of epithelial cells located_in the ectodermal or endodermal cells linking body cavities.]
protein fragment complementation method	BAO_0000406	[This is used to study the interaction of two proteins. An enzyme or fluorescent protein is rationally dissected into two fragments and fused to two test proteins, whose interaction is being studied. Binding of the two test proteins results in the reconstitution of the enzyme or fluorescent protein from the two fragments, which can be measured.]
radiometry method	BAO_0000657	[Detection technology using radioactive tracers, e.g. filter assay, SPA, etc]
x ray crystallography	BAO_0000404	[X-ray crystallography is used to analyze protein-small molecule interactions. This binding interaction is monitored by measuring the difference of diffraction between protein-compound binding complex and protein alone. With this technique, both the binding interaction and bound compounds can be detected, which allows pools of 5-100 compounds to be tested for binding.]
radioligand binding method	BAO_0000402	[It is used for analysis of receptor-ligand interactions in screening applications. It utilizes a radiolabeled ligand and a source of receptor (membranes, soluble/purified).]
filter assay	BAO_0000401	[This assay is performed to study interaction between a radio-labeled ligand and the receptor. The reaction mixture containing the receptor and radioligand is transferred to a filter plate, washed to remove the unbound radioligand. The bound complex remains on the filter, which can be eluted into the scintillation fluid and the radioactivity measured. Filter assays differ from SPA because a separation of free radioligand and radioligand bound to the receptor is required for measurement.]
epitope	CHEBI_53000
blepharophimosis, ptosis, and epicanthus inversus syndrome	DOID_14778
endpoint correction	BAO_0000419	[This refers to the correction performed on the raw data values from an assay. B-score correction is a common method used for this purpose.]
hemosiderosis	DOID_12119	[An iron metabolism disease that has_material_basis_in an accumulation of hemosiderin, an iron-storage complex, resulting in iron overload.]