Terminology Service < Semantic Lookup Platform

All terms in CL

Label	Id	Description
myeloid suppressor cell	CL_0000889	[An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive.]
receptor-type tyrosine-protein phosphatase C	PR_000001006	[A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule.]
lymph node tingible body macrophage	CL_0000888	[A lymph node macrophage found in the cortex of lymph nodes, in particular in and around the germinal centers, and that participates in phagocytosis of apoptotic B cells from the germinal centers.]
cortex of lymph node	UBERON_0002006	[Peripheral portion of the lymph node, underneath the capsule[WP].]
lobed	PATO_0001979	[A shape quality inhering in a bearer by virtue of the bearer's being partly divided into a determinate number of regions.]
shape	PATO_0000052	[A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc).]
lymph node subcapsular sinus macrophage	CL_0000887	[A lymph node macrophage found in the subcapsular sinus of lymph nodes that participates in sensing, clearance, and antigen presentation of lymph-borne particulate antigens. This macrophage is capable of activating invaraint NKT cells and is CD169-positive.]
capsule of lymph node	UBERON_0002194	[Capsule surrounding lymph node composed of connective tissue with some plain muscle fibers.]
nasal and broncial associated lymphoid tissue macrophage	CL_0000886	[A mucosa-associated lymphoid tissue macrophage found in the nasal and bronchial mucosa-associated lymphoid tissues.]
bronchial-associated lymphoid tissue	UBERON_0001963	[A diffuse collection of lymphpoid cells that participate in airway immune responses]
endothelial cell of Peyer's patch	CL_1000411	[An endothelial cell that is part of the small intestine Peyer's patch.]
small intestine Peyer's patch	UBERON_0003454	[nodular lymphoid structures on the serosal surface of the small intestine.]
cranial cavity	UBERON_0013411	[Anatomical cavity that is the lumen of the skull and contains the brain.]
nodal myocyte	CL_0002072	[A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery.]
atrioventricular node	UBERON_0002352	[An area of conducting tissue between the atria and the ventricles of the heart that conducts the normal electrical impulse from the atria to the ventricles.]
smooth muscle cell derived foam cell	CL_0000892	[A type of foam cell derived from a smooth muscle cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions.]
alternatively activated macrophage	CL_0000890	[An elicited macrophage characterized by low production of pro-inflammatory and Th1 polarizing cytokines and high expression of arginase-1, and associated with tissue remodelling.]
activated CD4-positive, alpha-beta T cell	CL_0000896	[A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive.]
naive thymus-derived CD4-positive, alpha-beta T cell	CL_0000895	[An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low.]
naive T cell	CL_0000898	[Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low.]