Terminology Service < Semantic Lookup Platform

All terms in EFO

Label	Id	Description
RNA-DNA SPRITE	EFO_0009986	[RNA-DNA SPRITE is a type of SPRITE experiment in which RNA in the cross-linked complexes is converted to cDNA before the initial splitting step, allowing analysis of RNA-DNA interactions.]
response to metamizole	EFO_0010971	[Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of metamizole stimulus. Metamizole is an analgesic that carries a risk of causing agranulocytosis.]
metamizole	CHEBI_62088	[A pyrazole that is antiipyrine substituted at C-4 by a methyl(sulfomethyl)amino group, the sodium salt of which, metamizole sodium, was widely used as a powerful analgesic and antipyretic, but withdrawn from many markets from the 1970s due to a risk of causing risk of causing agranulocytosis.]
blood phosphate measurement	EFO_0010972	[The amount of phosphorus, measured as inorganic phosphate, in a specified sample of blood.]
GAM	EFO_0009987	[Genome architecture mapping (GAM) is an assay designed to analyze 3D chromatin structure without relying on digestion and ligation. The procedure involves cryosectioning samples in random orientation, and then single nuclear profiles are isolated by laser microdissection. Each nuclear profile then undergoes high-throughput sequencing, and subsequent analysis can generate a matrix of inferred proximity between genomic regions.]
Ictalurus punctatus	NCBITaxon_7998
MC-Hi-C	EFO_0009980	[A multi-contact chromosome conformation capture assay in which DNA is not sheared after proximity ligation so that long read sequencing can be performed on reads with multiple ligated fragments.]
Hi-C	EFO_0007693	[Hi-C is a method for analysing 3-dimensional organisation and interaction of chromatin, belonging to the class of techniques collectively called "Chromosome Conformation Capture", in which chromatin is crosslinked, then digested, and re-ligated in such a way that only DNA fragments that are covalently linked together form ligation products. Together with 5C, Hi-C does not limit to the study to a specific locus in the genome, and can be used to study chromatin interaction across the genome. To achieve high-throughput, a biotin-labeled nucleotide is incorporated at the ligation junction, enabling selective purification of chimeric DNA ligation junctions followed by deep sequencing. Mapping the sequenced reads back to genome will reveal the origin of the fragments involved in the ligation events.]
infectious ectromelia	EFO_0007325	[A viral infection of mice, causing edema and necrosis followed by limb loss., A viral infectious disease that results_in infection located in skin of mice, has_material_basis_in Ectromelia virus. The infection has_symptom swelling of the feet, has_symptom gangrene, and has_symptom lesions on the skin.]
Schizophyllum commune	NCBITaxon_5334
severe malarial anemia	EFO_0010970	[Severe malarial anemia is a leading cause of malaria-related morbidity and mortality in children. Inefficient erythropoiesis is a central pathogenic feature.]
inclusion conjunctivitis	EFO_0007324	[Inflammation of the conjunctiva in a newborn due to Chlamydia trachomatis which was acquired during labor and delivery., A commensal bacterial infectious disease that results_in inflammation, located_in conjunctiva of the eye, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact. The infection has_symptom swollen conjunctiva and eyelids and has_symptom discharge of pus and mucus.]
PLAC-seq	EFO_0009981	[PLAC-seq (proximity ligation-assisted ChIP-seq) is similar to a Hi-C assay, but following proximity ligation, immunoprecipitation is performed using an antibody to a transcription factor or histone modification. This results in a Hi-C library enriched for a specific DNA-protein interaction. This procedure differs from ChIA-PET in that the proximity ligation step is performed prior to chromatin shearing and immunoprecipitation.]
IP-seq	EFO_0005032	[IP-seq is an assay in which immunoprecipitation with high throughput sequencing is used to identify the DNA/RNA-associated proteins or protein complexes. As an immunoprecipitation it can be ChIP, RIP or another immunoprecipitation process.]
inclusion body myositis	EFO_0007323	[A slowly progressive degenerative inflammatory disorder of skeletal muscles characterized by late onset weakness of specific muscles and distinctive histopathological features., A myositis that is characterized by slowly progressive weakness and wasting of both distal and proximal muscles, most apparent in the muscles of the arms and legs that can occur in a sporadic or hereditary forms.]
myositis	EFO_0000783	[Inflammation of a muscle or muscle tissue., An inflammatory disease involving a pathogenic inflammatory response in the muscle tissue., An inflammatory process affecting the skeletal muscles. Causes include infections, injuries, and autoimmune disorders.]
Trac-Loop	EFO_0009982	[Trac-loop (transposase-mediated analysis of chromatin looping) is an assay designed to detect interacting genomic regions. Rather than the traditional Hi-C approach of digestion and proximity ligation, the procedure involves transposase-mediated insertion of an oligonucleotide linker between the pair of interacting regions.]
MC-4C	EFO_0009983	[MC-4C is a multi-contact 4C experiment. After proximity ligation and target region amplification, multiple DNA fragments may be ligated together, and rather than shearing into smaller pieces for short read library preparation, the DNA is isolated and long read sequencing is performed.]
4C	EFO_0007690	[Chromosome conformation capture-on-chip (4C) is an extension of the 3C (Chromosome conformation capture) technique that studies 3-dimensional organisation and interaction of chromatin in a cell. 4C captures interactions between one specific locus and all other genomic loci. It involves a second ligation step, to create self-circularized DNA fragments, which are used to perform inverse PCR. Inverse PCR allows the known sequence to be used to amplify the unknown sequence ligated to it. In contrast to 3C and 5C, the 4C technique does not require the prior knowledge of both interacting chromosomal regions. Results obtained using 4C are highly reproducible with most of the interactions that are detected between regions proximal to one another. On a single microarray, approximately a million interactions can be analyzed.]
idiopathic CD4-positive T-lymphocytopenia	EFO_0007322	[A rare immunodeficiency syndrome characterized by the decrease of the CD4-positive lymphocytes below 300 per cubic millimeter in the absence of identifiable immunodeficiency causes. Patients with this syndrome are at an increased risk of opportunistic infections., A lymphopenia that is caused by a reduction of CD4+ T lymphocytes.]