Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
GTF3C4 Gene	NCIT_C20667	[This gene plays a role in transcriptional regulation.]
Dorzolamide Sodium	NCIT_C29004	[The sodium salt of Dorzolamide. An inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid conversion of carbon dioxide and water into carbonic acid, protons and bicarbonate ions. Distributed throughout many cells and tissues, various carbonic anhydrases play important roles in mineral and metabolic homeostasis. (NCI04)]
Flotillin-2	NCIT_C68602	[Flotillin-2 (379 aa, ~42 kDa) is encoded by the human FLOT2 gene. This protein plays a role in neuronal signaling and caveolar membrane structure.]
GTF3C5 Gene	NCIT_C20668	[This gene plays a role in transcriptional regulation.]
Doxazosin Mesylate	NCIT_C29005	[The mesylate salt form of doxazosin, a quinazoline compound with smooth muscle relaxing activity. Doxazosin mesylate selectively antagonizes alpha-1-adrenergic receptors in smooth muscle of the bladder neck and prostate, thereby relaxing the smooth muscle and decreasing the obstruction and urethral resistance seen with benign prostate hyperplasia (BPH). This may improve BPH symptoms. This agent also blocks alpha-1-adrenergic receptors in peripheral vascular smooth muscle, which leads to vasodilatation and a subsequent decrease in peripheral vascular resistance.]
TFIIIB Subunit Gene	NCIT_C20669	[Human TFIIIB Subunit Genes, BDP1, BRF1, and, BRF2, encode protein subunits of RNA Polymerase III Transcription Initiation Factor IIIB, required for RNA polymerase III transcription. Transcription begins with TFIIIC recognition of promoter A and B boxes and TFIIIA, TFIIIB, and RNA polymerase III binding. 90-kDa BRF1 contains a C-terminal HMG2-related region and an N-terminal TFII2B-related sequence. 50-kDa BRF2 has a zinc ribbon domain and a core domain, necessary for complex formation with DNA. Involved in nucleation of a polymerase III initiation complex, BRF2 does not directly bind DNA but interacts with TBP, which binds cooperatively to the promoter. TBP, an essential component of TFIIIB, binds the highly charged C-terminus of BRF1. Highly hydrophilic BDP1 contains a DNA-ligase A1 ATP-dependent binding site and several potential phosphorylation sites. (NCI)]
Nutrient	NCIT_C68603
Doxepin Hydrochloride	NCIT_C29006	[A dibenzoxepin derivative and tricyclic antidepressant with antipruritic and sedative activities. Doxepin blocks the reuptake of norepinephrine and serotonin into presynaptic terminals thereby prolonging the availability of the monoaminergic neurotransmitters within the synaptic cleft and enhancing their action leading to sedative effects. Doxepin also has antagonistic effects on histamine (H1 and H2), 5-HT2, alpha-1 adrenergic, and muscarinic receptors. The antipruritic effect of this agent is the result mediated through inhibition of histamine receptors.]
Tricyclic Antidepressant	NCIT_C94727	[Mood-stimulating agents which contain a tricyclic structure and are used primarily in the treatment of affective disorders and related conditions. This group of agents appear to act through brain catecholamine systems.]
Nursing Informatics	NCIT_C20662	[The application of informatics methods to manage nursing information and improve healthcare.]
Informatics	NCIT_C18145	[An occupational discipline which unites information science with computer science. It is concerned with the development of techniques for the collection and manipulation of data, and the use of such data.]
Chemical_Formula	NCIT_C68604	[Concise expression about the atoms that constitute a particular chemical compound.]
Doxycycline Hyclate	NCIT_C29007	[The hyclate salt form of doxycycline, a synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. Doxycycline hyclate binds reversibly to the 30S ribosomal subunit, possibly to the 50S ribosomal subunit as well, thereby blocking the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This leads to an inhibition of protein synthesis. In addition, this agent has exhibited inhibition of collagenase activity.]
Hospitalization or Prolongation of Existing Hospitalization Required	NCIT_C68605	[An indication or description that an extended period of hospitalization is necessary.]
Hospitalization Required	NCIT_C50414	[A patient condition where evaluation and/or treatment in a hospital is considered mandatory.]
Doxycycline Calcium	NCIT_C29008	[The calcium salt form of doxycycline exhibiting antimicrobial activity. Doxycycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis. In addition, this agent has exhibited inhibition of collagenase activity. (NCI)]
Head and Neck Cancer pN2c TNM Finding v8	NCIT_C132650	[Head and neck cancer with metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)]
Head and Neck Cancer pN2 TNM Finding v8	NCIT_C132647	[Head and neck cancer with metastasis in a single ipsilateral lymph node 3 cm or smaller in greatest dimension and ENE(+); or metastasis in a single ipsilateral lymph node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension, ENE(-). (from AJCC 8th Ed.)]
Persistent or Significant Disability or Incapacity	NCIT_C68606	[An indication or description of a continuing and significant impairment.]
GTF3C3 Gene	NCIT_C20664	[This gene is involved in transcriptional regulation.]