Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Flurazepam Hydrochloride	NCIT_C29060	[The hydrochloride salt form of flurazepam, a member of the benzodiazepines and a long-acting depressor of the central nervous system (CNS) with sedative and hypnotic effects. Flurazepam binds to a specific site on the benzodiazepine-gamma-aminobutyric acid (GABA)-A-chloride ionophore receptor complex located on the neuronal membrane. Binding causes an allosteric modification of the receptor thereby enhancing the affinity of GABA to the receptor leading to an increase in the frequency of chloride-channel opening events, which leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential, and a decrease in neuronal excitability. By modulating binding of the GABA inhibitory neurotransmitter to GABA-A receptors in the ascending reticular activating system, flurazepam blocks arousal of the cortical and limbic system, thereby exerting its sedative and hypnotic effect.]
Metastatic Carcinoma of the Mouse Intestinal Tract	NCIT_C107674	[A carcinoma that arises from the intestinal tract of the mouse and has spread to other anatomic sites.]
Malignant Neoplasms of the Mouse Intestinal Tract	NCIT_C22151
Ginkgo	NCIT_C29072	[A substance derived from the plant Ginkgo biloba. Ginkgo biloba leaf extract contains potent anti-oxidants and substances believed to improve blood flow to the brain and peripheral tissues. Ginkgo biloba exocarp polysaccharides (GBEP) can inhibit proliferation and induce apoptosis and differentiation of tumor cells. As a medicinal herb, ginkgo requires standardization for medicinal use; typically, a 50:1 extract of ginkgo leaf is used in ginkgo supplements. (NCI04)]
IRF2BP2 Gene	NCIT_C107664	[This gene plays a role in transcriptional repression.]
Transcription Repressor/Corepressor Gene	NCIT_C20703	[RNA polymerase II transcription of Class II genes involves the TFIID transcription complex comprised of general factors, including TBP, TFIIA, TFIIB, TFIIE, TFIIF, TFIIG/J, and TFIIH, as well as gene-specific factors that include TAFs, which interact with regulatory protein activation domains to enhance transcription. Transcription Corepressor Genes encode a group of transcriptional repressor/co-repressor factors that suppress transcription by binding to the operator. (NCI)]
Glimepiride	NCIT_C29073	[A long-acting, third-generation sulfonylurea with hypoglycemic activity. Compared to other generations of sulfonylurea compounds, glimepiride is very potent and has a longer duration of action. This agent is metabolized by CYP2C9 and shows peroxisome proliferator-activated receptor gamma (PPARgamma) agonistic activity.]
IRF2BP2 wt Allele	NCIT_C107665	[Human IRF2BP2 wild-type allele is located in the vicinity of 1q42.3 and is approximately 5 kb in length. This allele, which encodes interferon regulatory factor 2-binding protein 2, is involved in the repression of interferon gene expression.]
Glipizide	NCIT_C29074	[A short-acting, second-generation sulfonylurea with hypoglycemic activity. Glipizide is rapidly absorbed, has a very quick onset of action and a short half-life. This agent is extensively metabolized in the liver and the metabolites as well as the unchanged form are excreted in the urine.]
HAQ-DI Without VAS - Open Car Doors	NCIT_C132600	[Health Assessment Questionnaire Disability Index Without Pain Visual Analog Scale (HAQ-DI Without VAS) Grip: Are you able to open car doors?]
Interferon Regulatory Factor 2-Binding Protein 2	NCIT_C107666	[Interferon regulatory factor 2-binding protein 2 (587 aa, ~61 kDa) is encoded by the human IRF2BP2 gene. This protein plays a role in the negative regulation of interferon expression.]
Ring Finger Domain	NCIT_C13746	[The RING finger is a specialized type of Zn-finger consisting of 40 to 60 residues, which has the consensus sequence CX2CX(9-39)CX(1-3)HX(2-3)C/HX2CX(4-48)CX2C, that binds two atoms of zinc, and is involved in mediating protein-protein interactions. The RING domain mediates the interaction with the appropriate E2 enzyme. Unlike HECT E3 enzymes that form a thiol-ester with ubiquitin, RING fingers likely mediate ubiquitination by facilitating the direct transfer of ubiquitin from E2 enzyme to lysine residues on the target substrate.]
Glucosamine Sulfate	NCIT_C29075	[An amino sugar (2-amino, 2-deoxyglucose) in cell membranes, Glucosamine Sulfate is believed to play a role in cartilage formation and repair. Long-term glucosamine sulfate treatment retards progression of knee osteoarthritis; the mechanism appears to involve glucosamine's role as an essential substrate for glycosaminoglycans and hyaluronic acid, needed for formation of the joint proteoglycan structural matrix. (NCI04)]
HAQ-DI Without VAS - Open Jars Previously Opened	NCIT_C132601	[Health Assessment Questionnaire Disability Index Without Pain Visual Analog Scale (HAQ-DI Without VAS) Grip: Are you able to open jars which have been previously opened?]
CDX1 Gene	NCIT_C107667	[This gene is involved in gene expression in the intestine.]
Multiplier Device	NCIT_C54010	[A device designed to take an input and increase some characteristic of it.]
Glyburide	NCIT_C29076	[A sulfonamide urea derivative with antihyperglycemic activity that can potentially be used to decrease cerebral edema. Upon administration, glyburide binds to and blocks the sulfonylurea receptor type 1 (SUR1) subunit of the ATP-sensitive inwardly-rectifying potassium (K(ATP)) channels on the membranes of pancreatic beta cells. This prevents the inward current flow of positively charged potassium (K+) ions into the cell, and induces a calcium ion (Ca2+) influx through voltage-sensitive calcium channels, which triggers exocytosis of insulin-containing granules. In addition, glyburide also inhibits the SUR1-regulated nonselective cation (NC) Ca-ATP channel, melastatin 4 (transient receptor potential cation channel subfamily M member 4; (TRPM4)), thereby preventing capillary failure and brain swelling. SUR1-TRPM4 channels are formed by co-assembly of SUR1 with TRPM4 in neurons, astrocytes, and capillary endothelium during cerebral ischemia. Upon ischemia-induced ATP depletion, channels open which results in sodium influx, cytotoxic edema formation, capillary fragmentation and necrotic cell death. SUR1-TRPM4 is not expressed in normal, uninjured tissues.]
HAQ-DI Without VAS - Turn Faucets On And Off	NCIT_C132602	[Health Assessment Questionnaire Disability Index Without Pain Visual Analog Scale (HAQ-DI Without VAS) Grip: Are you able to turn faucets on and off?]
CDX1 wt Allele	NCIT_C107668	[Human CDX1 wild-type allele is located in the vicinity of 5q32 and is approximately 19 kb in length. This allele, which encodes homeobox protein CDX-1, plays a role in the regulation of intestinal gene expression.]
5q32	NCIT_C14126	[A chromosome band present on 5q]