Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Plasma Membrane Estrogen Receptor Signaling Pathway	NCIT_C91649
Gemfibrozil	NCIT_C29071	[A fibric acid derivative with hypolipidemic effects. Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III results in subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C).]
Striatin	NCIT_C107663	[Striatin (780 aa, ~86 kDa) is encoded by the human STRN gene. This protein may play a role in calcium-mediated signaling.]
NR0B2 Gene	NCIT_C20707	[This gene is involved in transcriptional regulation and can stimulate transcriptional repression.]
PCA3 mRNA to PSA mRNA Ratio Measurement	NCIT_C132378	[The determination of the ratio of prostate cancer antigen 3 mRNA as compared to the total prostate specific antigen mRNA present in a sample. The measurement may be expressed as a ratio or percentage.]
Ribonucleic Acid Measurement	NCIT_C132301	[The determination of the amount of ribonucleic acids in a biological sample.]
Orphan Nuclear Receptor Gene	NCIT_C20708	[Orphan Nuclear Receptor Genes (NR Superfamily) encode numerous Orphan Nuclear Receptor (NRs) transcription factors thought to be activated by as yet unknown ligands. Transducing cellular signals into gene transcription, NRs regulate development, pattern formation, cell proliferation, cell differentiation, and homeostasis in target tissues. NRs share a common organization: an (N) modulatory domain, a conserved central Cys-rich region of two C4 zinc fingers that bind to specific upstream ligand-responsive target DNA elements, and a (C) ligand-binding domain. Stabilizing hydrophobic zinc finger interactions contribute to DNA binding specificity, homodimerization, and interaction with other proteins. Ligand-bound NR conformation allows coactivator interaction with the ligand-binding domain that mediates interaction with heat shock proteins, cyclophilins, and ligand. (NCI)]
Prostate Cancer Antigen 3 mRNA Measurement	NCIT_C132379	[The determination of the amount of prostate cancer antigen 3 mRNA in a biological sample.]
NRIP1 Gene	NCIT_C20704	[This gene is involved in regulation of transcription.]
MHC Class II Protein	NCIT_C20705	[MHC Class-II Proteins are non-covalently linked polymorphic alpha/beta transmembrane glycoproteins. The immunological function of MHC Class-II proteins is to bind and present antigenic peptides on the surfaces of cells for recognition by the antigen-specific T cell receptors of lymphocytes. These proteins plays an important role in the mediation of immune response.]
HLA Complex	NCIT_C121977	[A family of proteins that are essential for the presentation of peptide antigens on cell surfaces that modulate the host defensive activities of T-cells. This protein family includes major histocompatibility complex (MHC) class I and class II proteins.]
MHC Class I Protein	NCIT_C20706	[Found on virtually every cell, MHC (Major Histocompatibility, HLA) Class-I (Antigens) Proteins consist of noncovalently bound polymorphic 44-kDa MHC membrane glycoprotein and nonpolymorphic 12-kDa b2-microglobulin. The HLA antigens are encoded by closely linked multiallelic genes of the HLA (MHC) complex, a region containing several genetic loci (HLA-A, -B, -C, -DP, -DQ, -DR, -MB, -MT, and -Te).]
CD8-Positive T-Lymphocyte	NCIT_C12542	[A subset of T-lymphocytes that express the CD8 surface glycoprotein and bind epitopes that are part of class I histocompatibility molecules. CD8-positive T-lymphocytes include cytotoxic T-lymphocytes and CD8+ suppressor T-lymphocytes.]
MHC Class I Gene	NCIT_C16617	[A family of genes that encode major histocompatibility complex proteins and are involved in the presentation of cytoplasmic protein fragments to cytotoxic lymphocytes.]
1,3-Beta-D-Glucan Measurement	NCIT_C132370	[The determination of the amount of 1,3-beta-D-glucan in a biological sample.]
NCOA5 Gene	NCIT_C20700	[This gene is involved in regulation of transcription.]
Glycerol Measurement	NCIT_C132371	[The determination of the amount of glycerol in a biological sample.]
Alcohol Abuse	NCIT_C20701	[The use of alcoholic beverages to excess, either on individual occasions ("binge drinking") or as a regular practice.]
Substance Abuse	NCIT_C18272	[Maladaptive pattern of drug or alcohol use that may lead to social, occupational, psychological, or physical problems.]
Keyhole Limpet Hemocyanin IgG Antibody Measurement	NCIT_C132372	[The determination of the amount of keyhole limpet hemocyanin IgG antibody in a biological sample.]