Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
MD Anderson Symptom Inventory - Lung Chemoradiation	NCIT_C107379	[A self-administered questionnaire designed specifically for evaluating the severity of symptoms related to lung cancer and chemoradiation treatment.]
Unapproved Drug Product Manufactured Under Contract	NCIT_C132335	[A marketing category specifying that an unapproved drug product is manufactured by a contract manufacturer and not marketed by the contract manufacturer.]
Guideline Concordant Care	NCIT_C132336	[Treatment that is in compliance with established guidelines.]
ARHGEF5 Gene Product	NCIT_C132337	[A protein encoded by the ARHGEF5 gene.]
ARHGEF5 Gene	NCIT_C18528	[This gene plays a role in signal transduction and is putatively involved in cytoskeletal remodeling.]
GAS2 Gene	NCIT_C20747	[This gene plays a role in the regulation of actin cytoskeletal components and in cellular motility.]
Oncogene TIM Protein	NCIT_C132338	[Oncogene TIM protein (519 aa, ~60 kDa) is encoded by the human ARHGEF5 gene. This protein is involved in the activation of Rho family small GTPases and may induce cellular transformation.]
DH Domain	NCIT_C14076	[The Dbl homology (DH) or RhoGEF domain consists of a 150 amino acid region that induces Rho family GTPases to displace GDP. This effectively activates the Rho GTPase by allowing binding to GTP, which is in excess over GDP in the cell. The DH domain is invariably proceeded by a pleckstrin homology (PH) domain. While not absolutely required for catalysis of nucleotide exchange, the PH domain appears to greatly increase catalytic efficiency in many cases. Rho proteins control actin dynamics, gene expression, membrane trafficking, growth factor signaling, and cellular transformation. Proteins encoding DH domains (RhoGEFs) also play a role in these events as they function as the primary activators of Rho GTPases. In fact, many RhoGEFs were identified based on their transforming activity, which was abrogated upon disruption of their DH domain. (Pawson Lab, SLRI, Mount Sinai Hospital, 2003)]
Anti-LAG-3 Monoclonal Antibody REGN3767	NCIT_C132339	[A monoclonal antibody directed against the inhibitory receptor lymphocyte activation gene-3 protein (LAG-3; LAG3; CD223), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, the anti-LAG-3 monoclonal antibody REGN3767 binds to LAG-3 expressed by tumor infiltrating lymphocytes (TILs) and blocks LAG-3 binding to tumor cells expressing major histocompatibility complex (MHC) class II molecules. This may activate antigen-specific T-lymphocytes and enhance cytotoxic T-lymphocyte (CTL)-mediated tumor cell lysis, which leads to a reduction in tumor growth. LAG-3, a member of the immunoglobulin superfamily (IgSF), is expressed on various immune cells; its expression on TILs is associated with tumor-mediated immune suppression and the negative regulation of both cellular proliferation and T-cell activation.]
Anti-LAG-3 Monoclonal Antibody	NCIT_C134305	[Any monoclonal antibody directed against the antigen lymphocyte-activation gene 3 (LAG-3; CD223).]
Segmental Mastectomy	NCIT_C20749	[The removal of a cancer as well as some of the breast tissue around the tumor and the lining over the chest muscles below the tumor. Usually some of the lymph nodes under the arm are also taken out. Also called partial mastectomy. (Cancer.gov)]
FGFR4 Gene	NCIT_C20743	[This gene plays a role in mitogenesis and differentiation.]
Cell Movement	NCIT_C28486	[Cell Movement involves translocation of a whole cell, or cell body, from one site to another; distinct from cell motion that involves movement of cell processes (e.g., axons, microvilli, etc.). (NCI)]
B-Cell CLL/Lymphoma 9-Like Protein	NCIT_C132330	[B-cell CLL/lymphoma 9-like protein (1499 aa, ~157 kDa) is encoded by the human BCL9L gene. This protein plays a role in the promotion of beta-catenin transcriptional activity.]
Human Cytomegalovirus Envelope Glycoprotein B	NCIT_C132331	[Envelope glycoprotein B (906 aa; ~102 kDa) is encoded by the human cytomegalovirus gB gene, which is located within the open reading frame (ORF) UL55. This protein is involved in host cell entry, cell to-cell virus transmission, and fusion of infected cells.]
Tumor Cell Mobility	NCIT_C20741	[Any type of motility of a tumor cell that involves translocation of the cell, or cell body, from one site to another; distinct from forms of cell movement that involve only movement of cell processes (e.g., axons, microvilli, etc.). (NCI)]
Extravascular Extracellular Volume Fraction	NCIT_C132332	[The ratio of interstitial fluid volume to total body fluid.]
Approved Drug Product Manufactured Under Contract	NCIT_C132333	[A marketing category specifying that an approved drug product is manufactured by a contract manufacturer and not marketed by the contract manufacturer.]
PTEN Coding Region Mutation Present	NCIT_C146986	[A genetic finding indicating that a sample has one or more exon mutations in the PTEN gene.]
PTEN Gene Alteration Positive	NCIT_C153466	[An indication that mutation, overexpression, fusion or rearrangement involving the PTEN gene has been detected in a sample.]