Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Skin Test	NCIT_C17137	[A preparation of an antigenic component of an infectious agent that is administered to a patient in order to determine whether previous exposure to the agent has occurred, and/or to assess the integrity of the patient's cellular immune system. Depending on the clinical situation, the appearance of a delayed (cellular) hypersensitivity response, which manifests as an area of induration and erythema at the injection site, i.e. a positive test result, may indicate previous exposure to a particular infectious agent. (NCI04)]
BCL9L Gene	NCIT_C132328	[This gene plays a role in the coactivation of gene transcription.]
Id MM Vaccine Test	NCIT_C29111	[A test consisting of a myeloma idiotype (Id)-specific protein conjugated to the immunogen keyhole limpet hemocyanin (KLH). As a test of innate host delayed-type hypersensitivity (DTH) and host DTH in response to therapeutic vaccination, Id MM vaccine test is performed intradermally before and after therapeutic vaccination in multiple myeloma patients treated with Id-specific vaccines. (NCI04)]
BCL9L wt Allele	NCIT_C132329	[Human BCL9L wild-type allele is located in the vicinity of 11q23.3 and is approximately 32 kb in length. This allele, which encodes B-cell CLL/lymphoma 9-like protein, is involved in transcriptional activation.]
Interleukin-2 Anti-Idiotype Vaccine	NCIT_C29112	[A vaccine based on anti-idiotype (Id) monoclonal antibodies combined with interleukin-2 (IL-2). Anti-Id vaccines have been shown to be effective in treatment of B-cell lymphoma in animal models and in clinical trials, resulting in tumor regression; the addition of interleukin-2 (IL-2) may augment the therapeutic effect of anti-Id vaccines. (NCI04)]
Anti-Idiotype Vaccine	NCIT_C2590
BCPR Gene	NCIT_C20776	[Human BCPR wild-type allele is located in the vicinity of 17p13.3 and the length of the gene is currently unknown. This allele, which encodes breast cancer-related regulator of TP53 protein, plays a role in tumor suppression.]
Imexon	NCIT_C29115	[A 2-cyanoaziridine derivative with antitumor activity in multiple myeloma. Although its mechanism of action is not clearly known, imexon may induce apoptosis via a pathway involving cleaved caspase-3, caspase-9, and/or caspase-8. Other cytotoxic mechanisms of action of this agent may involve thiol depletion, generation of reactive oxygen species (ROS), and decreases in the mitochondrial membrane potential. (NCI04)]
Signal Induction	NCIT_C19656	[Signal induction is the intercellular or intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (e.g., hormone, neurotransmitter, etc.) is transferred to a receptor molecule through a physical binding interaction that alters the conformational and functional state of the receptor molecule and promotes an alteration in cell function.]
BRCA3 Gene	NCIT_C20779	[Human BRCA3 gene is located in the vicinity of 13q21 the size of this phenotypic locus is not reported. This gene has no known product and may play a role in tumor suppression. Mutation of this locus is associated with breast cancer.]
13q21	NCIT_C13868	[A chromosome band present on 13q]
Imipramine Hydrochloride	NCIT_C29116	[The hydrochloride salt form of imipramine, a synthetic tricyclic derivative, antidepressant Imipramine enhances monoamine neurotransmission in certain areas of the brain. It also induces sedation through histamine 1 receptor blockage; hypotension through beta-adrenergic blockage; and diverse parasympatholytic effects. Imipramine has less sedative effect than other members of its therapeutic family. It is used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. (NCI04)]
Immutol	NCIT_C29117	[A purified Norwegian Beta-Glucan (NBG), extracted from the cell walls of baker's yeast. Used as an immunostimulant in complementary medicine, NBG binds specifically to receptors found on the surface of specialized macrophages, granulocytes and natural killer cells and may stimulate these cells to become more active in engulfing and digesting foreign antigens; NBG also induces the production of cytokines that further augment the host immune response to foreign antigens. Use of this agent may enhance overall resistance to infectious agents and promote wound healing and tissue repair. (NCI04)]
CDISC SDTM Malaria Findings About Test Code Terminology	NCIT_C132320	[Terminology associated with the malaria findings about test code codelist of the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).]
Indapamide	NCIT_C29119	[An indole derivative of chlorosulphonamide and a sulfamyl diuretic with antihypertensive activity. Indapamide may interact directly with the subunits of delayed rectifier potassium channels, thereby blocking both slow and rapid K+ (IKs and IKr) currents through the channels. Through the homeostasis mechanism in balancing total ion concentration (Ca++, Na+), it reduces vascular hyperreactivity and peripheral and arterial vascular resistance, possibly by inhibiting transmembrane ionic influx, probably calcium ions, and stimulating prostaglandin E2 synthesis, thereby causing vasodilatation. Indapamide exerts its diuretic effect by inhibiting reabsorption of sodium and chloride, primarily as a result of action on the cortical diluting segment of the renal distal tubule, thereby promoting urinary excretion of water and electrolytes.]
CDISC SEND Within Normal Limits Results Terminology	NCIT_C132321	[Terminology associated with the within normal limits results codelist of the Clinical Data Interchange Standards Consortium (CDISC) Standard for the Exchange of Non-clinical Data (SEND).]
BRCD1 Gene	NCIT_C20775	[Human BRCD1 gene is located within chromosome 13 and the size of this phenotypic locus is not reported. This phenotype-only gene has not been linked to a known protein product. Mutation of this locus is associated with radioresistance of several types of cancers; including, retinoblastoma, mesenchymal tumors and ductal carcinoma.]
Chromosome 13	NCIT_C13208	[The designation for each member of the thirteenth largest human autosomal chromosome pair. Chromosome 13 spans about 113 million base pairs and represents between 3.5 and 4% of the total DNA in normal diploid cells.]
Protein Secretion	NCIT_C18971	[Vectorial transport of proteins across a cell membrane to the extracellular environment.]
GNAS NM_000516.5:c.374A>G	NCIT_C146953	[A nucleotide substitution at position 374 of the coding sequence of the GNAS gene where adenine has been mutated to guanine.]