Terminology Service for NFDI4Health
All terms in NCIT
| Label | Id | Description |
|---|---|---|
| Linezolid | NCIT_C29158 | [A synthetic oxazolidinone derivative, Linezolid selectively inhibits an early step in bacterial protein synthesis and affects blood pressure through monoamine oxidase inhibition. It is effective against Gram-positive organisms, including methicillin-resistant Staphylococcus aureus strains, coagulase-negative Staphylococci, vancomycin-resistant Enterococci, and penicillin-resistant Streptococcus pneumoniae strains. (NCI04)] |
| TOX3 wt Allele | NCIT_C68711 | [Human TOX3 wild-type allele is located in the vicinity of 16q12.1 and is approximately 110 kb in length. This allele, which encodes TOX high mobility group box family member 3 protein, may play a role in the regulation of transcription.] |
| 16q12.1 | NCIT_C38482 | [A chromosome band present on 16q] |
| TP53 NM_000546.5:c.797G>T | NCIT_C146907 | [A nucleotide substitution at position 797 of the coding sequence of the TP53 gene where guanine has been mutated to thymine.] |
| TP53 NP_000537.3:p.G266V | NCIT_C146908 | [A change in the amino acid residue at position 266 in the cellular tumor antigen p53 protein where glycine has been replaced by valine.] |
| Lisinopril | NCIT_C29159 | [An orally bioavailable, long-acting angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Lisinopril, a synthetic peptide derivative, specifically and competitively inhibits ACE, which results in a decrease in the production of the potent vasoconstrictor angiotensin II and, so, diminished vasopressor activity. In addition, angiotensin II-stimulated aldosterone secretion by the adrenal cortex is decreased which results in a decrease in sodium and water retention and an increase in serum potassium.] |
| TOX High Mobility Group Box Family Member 3 | NCIT_C68712 | [TOX high mobility group box family member 3 protein (576 aa, ~63 kDa) is encoded by the human TOX3 gene. This protein may be a transcription factor.] |
| HMG-Box | NCIT_C13744 | [The HMG-Box Domain binds to and bends the minor groove of the DNA. This domain can recognize and bind to altered DNA conformations, such as stem-loops, four-way junctions, and specifically kinked or underwound DNA. (Mol Cell Biol 1999 Aug;19(8):5237-46)] |
| LSP1 Gene | NCIT_C68713 | [This gene may play a role in neutrophil function.] |
| TP53 NM_000546.5:c.797G>A | NCIT_C146909 | [A nucleotide substitution at position 797 of the coding sequence of the TP53 gene where guanine has been mutated to adenine.] |
| TP53 NP_000537.3:p.G266E | NCIT_C146910 | [A change in the amino acid residue at position 266 in the cellular tumor antigen p53 protein where glycine has been replaced by glutamic acid.] |
| LSP1 wt Allele | NCIT_C68714 | [Human LSP1 wild-type allele is located in the vicinity of 11p15.5 and is approximately 39 kb in length. This allele, which encodes lymphocyte-specific protein 1, may be involved in the regulation of neutrophil motility, adhesion, and transendothelial migration.] |
| Lymphocyte-Specific Protein 1 | NCIT_C68715 | [Lymphocyte-specific protein 1 (339 aa, ~37 kDa) is encoded by the human LSP1 gene. This protein binds actin and may play a role in neutrophil functions including motility, adhesion to fibrinogen matrix proteins, and transendothelial migration.] |
| Indian Health Service | NCIT_C68716 | [An agency within the Department of Health and Human Services. It is responsible for providing comprehensive health services to American Indians and Alaska Natives through IHS and tribally contracted hospitals, health centers, school health centers, and health stations.] |
| Assay Unit | NCIT_C68717 | [A unit used for measuring substance concentration or/and activity as defined in the literature reference standard for the particular assay method.] |
| TP53 NM_000546.5:c.814G>A | NCIT_C146912 | [A nucleotide substitution at position 814 of the coding sequence of the TP53 gene where guanine has been mutated to adenine.] |
| TP53 NP_000537.3:p.V272M | NCIT_C146913 | [A change in the amino acid residue at position 272 in the cellular tumor antigen p53 protein where valine has been replaced by methionine.] |
| TP53 NM_000546.5:c.818G>A | NCIT_C146914 | [A nucleotide substitution at position 818 of the coding sequence of the TP53 gene where guanine has been mutated to adenine.] |
| TP53 NP_000537.3:p.R273H | NCIT_C146915 | [A change in the amino acid residue at position 273 in the cellular tumor antigen p53 protein where arginine has been replaced by histidine.] |
| Xq | NCIT_C13566 | [Distal (long) arm of chromosome X] |