Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Magnesium Citrate	NCIT_C29241	[The citrate salt of the element magnesium with cathartic activity. The cathartic action of magnesium cations appears to result, in part, from osmotically mediated water retention, which subsequently stimulates peristalsis. In addition, magnesium ions may also stimulate the activity of nitric oxide (NO) synthase and increase the biosynthesis of the phospholipid proinflammatory mediator platelet activating factor (PAF) in the gut. NO may stimulate intestinal secretion via prostaglandin- and cyclic GMP-dependent mechanisms while PAF produces significant stimulation of colonic secretion and gastrointestinal motility.]
Superior Pubic Ramus	NCIT_C132415	[The portion of the pubic ramus that lies between the body of the ilium and the inferior pubic ramus.]
Cyclic AMP-Dependent Transcription Factor ATF-4	NCIT_C107459	[Cyclic AMP-dependent transcription factor ATF-4 (351 aa, ~39 kDa) is encoded by the human ATF4 gene. This protein plays a role in the regulation of gene transcription.]
cAMP Responsive Element Binding Protein	NCIT_C17286	[Ubiquitously or widely expressed human cAMP Responsive Element Binding Proteins (bZIP/CREB Family) are conserved nuclear bZIP domain dimeric transcription factors that bind to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and cellular promoters and induce gene transcription in response to cAMP signaling pathways. CREB proteins bind to DNA as a homodimer or a heterodimer with JUN/c-Jun or ATF2/CREBP1. Increased cAMP levels following stimulation activate cAMP-dependent protein kinase A, which phosphorylates CREB proteins that stimulate transcription of cAMP-responsive genes. Calcium-regulated CREB transcription factors integrate calcium and cAMP signals. cAMP pathways provide a chief means by which cellular growth, differentiation, and function can be influenced by extracellular signals. (NCI)]
Magnesium Oxide	NCIT_C29242	[The oxide salt of magnesium with antacid, laxative and vascular smooth muscle relaxant activities. Magnesium combines with water to form magnesium hydroxide which reacts chemically to neutralize or buffer existing quantities of stomach acid; stomach-content and intra-esophageal pH rise, resulting in a decrease in pepsin activity. This agent's laxative effect is the result, in part, of osmotically mediated water retention, which subsequently stimulates peristalsis. In addition, magnesium ions may behave as calcium antagonists in vascular smooth muscle.]
Microoganism Identification	NCIT_C132416	[The determination of the type of microorganism in a biological sample.]
Asexual Plasmodium knowlesi Measurement	NCIT_C132417	[The determination of the amount of the organism assigned to the Plasmodium knowlesi species in the asexual phase in a biological sample.]
Bidirectional	NCIT_C54200	[Reactive or functioning or allowing movement in two usually opposite directions.]
Choline Magnesium Trisalicylate	NCIT_C29244	[A nonsteroidal anti-inflammatory drug (NSAID) belonging to the salicylate family. Choline magnesium trisalicylate inhibits inflammation-related prostaglandin synthesis. This agent's analgesic effect is mediated through peripheral and central pathways, resulting in a decrease in pain perception; its antipyretic effect is mediated via the hypothalamic heat regulation center. (NCI04)]
Sexual Plasmodium knowlesi Measurement	NCIT_C132418	[The determination of the amount of the organism assigned to the Plasmodium knowlesi species in the sexual phase in a biological sample.]
Autologous Ad-CD154-Transduced CLL B Cells	NCIT_C68842	[An autologous tumor cell vaccine containing chronic lymphocytic leukemia (CLL) B cells transduced with an adenoviral vector carrying chimeric CD154 (ad-CD154) with potential antineoplastic activity. Administration of autologous ad-CD154 transduced CLL B cells may result in increases in the numbers of leukemia-specific CD4+ T cells and high serum-levels of IL-12 and IFN-gamma. Due to ligation of CD154 to CD40 on CLL cells, this agent may induce CLL cells to express the proapoptotic molecule BID and death receptors CD95 (Fas) and DR5, rendering CLL B cells first resistant and then sensitive to Fas-mediated apoptosis. In addition, autologous ad-CD154 transduced CLL B cells may induce MHC class I-dependent cytotoxic T lymphocyte (CTL) responses against autologous leukemia cells. CD154 is a type II membrane glycoprotein and ligand for CD40; both molecules are important in cognate co-stimulatory cell-cell interactions.]
Meclizine Hydrochloride	NCIT_C29245	[The hydrochloride salt form of meclizine, a synthetic piperazine with anti-emetic, sedative and histamine H1 antagonistic properties. Meclizine hydrochloride blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial and gastrointestinal smooth muscles, including vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscles. Meclizine hydrochloride may exert its antiemetic effects by its anticholinergic actions or due to a direct effect on the medullary chemoreceptive trigger zone.]
Calorie 15 Degrees Celsius	NCIT_C68843	[A non-SI unit of energy defined as the amount of heat required to raise the temperature of one gram of pure water by one degree (from 14.5 to 15.5 C or from 287.65 to 288.65 K) under standard conditions with the specific heat of the water at 15 degrees Celsius and the constant pressure of 101.325 kPa or one atm being defined as unity. A value recorded by ISO for the calorie at 15 degrees Celsius is 4.1855 J. According to the current national standard in the United States (IEEE/ASTM SI 10TM 2002. American National Standard for Use of the International System of Units (SI): The Modern Metric System, New York: IEEE, 2002) the calorie in any form is not to be used. Joules should be used instead.]
Clindamycin/Hydrocortisone Lotion	NCIT_C68844	[A topical lotion, containing clindamycin and hydrocortisone, with antibacterial and anti-inflammatory activities. Clindamycin, a lincomycin antibiotic, binds to the 50S subunit of the bacterial ribosome, thereby inhibiting bacterial protein synthesis. As a glucocorticoid agonist, hydrocortisone promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppression of immune and inflammatory responses.]
Diatrizoate Meglumine	NCIT_C29247	[The meglumine salt form of diatrizoate, an organic, iodinated, radiopaque X-ray contrast medium used in diagnostic radiography. The iodine moiety of diatrizoate meglumine is not penetrable by X-rays, therefore blocks the X-ray film exposure by radiation. This makes it possible to distinguish on X-ray film, body parts that contain diatrizoate meglumine from body parts that do not contain this agent and allows for visualization of different body structures.]
Abiraterone Acetate	NCIT_C68845	[An orally active acetate sester form of the steroidal compound abiraterone with antiandrogen activity. Abiraterone inhibits the enzymatic activity of steroid 17alpha-monooxygenase (17alpha-hydrolase/C17,20 lyase complex), a member of the cytochrome p450 family that catalyzes the 17alpha-hydroxylation of steroid intermediates involved in testosterone synthesis. Administration of this agent may suppress testosterone production by both the testes and the adrenals to castrate-range levels.]
CYP17A1 Inhibitor	NCIT_C147923	[Any agent that inhibits the activity of the enzyme CYP17A1.]
Meropenem	NCIT_C29248
Global	NCIT_C68846	[Covering or affecting the whole of a system.]
Mesalamine	NCIT_C29249	[An agent derived from sulfasalazine, an antiinflammatory agent. Mesalamine may reduce inflammation through inhibition of cyclooxygenase and prostaglandin production. Following rectal or oral administration, only a small amount of mesalamine is absorbed; the remainder, acting topically, reduces bowel inflammation, diarrhea, rectal bleeding and stomach pain. (NCI04)]