Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Medium Chain Fatty Acid	NCIT_C68391	[A class of dietary fatty acids that have an alkyl chain length from 6 up to 12 carbon atoms.]
ORC4 Gene	NCIT_C20387	[This gene is involved in DNA binding, initiation of DNA replication and transcriptional silencing. It also plays a role in ATP hydrolysis and the maintenance of cell viability.]
ORC Subunit Gene	NCIT_C20371	[DNA replication is initiated by the Origin Recognition Complex (ORC). ORC is composed of six protein subunits and binds to the ARS Consensus Sequence (ACS) of Origins of Replication in an ATP-dependent manner. While ORC remains bound to origins throughout the cell cycle, the binding of ORC and other factors modulates local chromatin structure to facilitate replication initiation. All 6 genes encoding ORC (ORC1 through ORC6) may be required for initiation of DNA replication and are essential for viability.]
Replication Initiation	NCIT_C28677	[DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to begin DNA synthesis. In eukaryotic cells, the primer is synthesized by DNA polymerase alpha:primase. First, the DNA primase portion of this complex synthesizes approximately 6-10 nucleotides of RNA primer and then the DNA polymerase portion synthesizes an additional 20 nucleotides of DNA. (from MedLine 11395402)]
ORC5 Gene	NCIT_C20388	[This gene plays a role in DNA binding and the initiation of DNA replication. It is also involved in negative regulation of transcription.]
ORC6 Gene	NCIT_C20389	[This gene is involved in DNA binding, initiation of DNA replication and transcriptional silencing.]
Protein Phosphatase 2A Subunit Gene	NCIT_C20396	[The Protein Phosphatase 2A Subunit Genes encodes 3 subunits (A, B, and C) of Protein Phosphatase 2A (PP2A) holoenzyme, a heterotrimeric serine/threonine phosphatase. The structural A subunit and the catalytic C subunit form a catalytic core, while substrate specificity is directed by the B subunit. PP2A exerts regulatory control over the initiation of DNA replication and has a particularly complex set of regulatory subunits controlling its function and localization.]
Caproic Acid	NCIT_C68330	[A saturated medium-chain fatty acid with a 6-carbon backbone. Caproic acid is found naturally in various plant and animal fats and oils.]
PPP2R3B Gene	NCIT_C20397	[This gene is involved in signal transduction.]
Octanoic Acid	NCIT_C68331	[A saturated medium-chain fatty acid with an 8-carbon backbone. Octanoic acid is found naturally in the milk of various mammals and is a minor component of coconut oil and palm kernel oil.]
ORC3 Gene	NCIT_C20390	[This gene plays a role in DNA binding and the initiation of DNA replication. It is also involved in transcriptional silencing.]
Cephalin	NCIT_C68332	[A phospholipid with the polar ethanolamine found in phosphoester linkage to diacylglycerol.]
Dietary Phospholipid	NCIT_C68340	[Any substance found in the diet, comprising a glycerol backbone covalently bound to fatty acids in 2 positions, and to a phosphate group in the third position. Dietary phospholipids also include molecules derived physiologically from this basic structure. Fatty acid components of dietary phospholipids can be any of a broad variety found in nature.]
Cetoleic Acid	NCIT_C68333	[A monounsaturated very long-chain fatty acid with a 22-carbon backbone and a single double bond originating from the 11th position from the methyl end.]
Docosenoic Acid	NCIT_C68352	[A monounsaturated very long-chain fatty acid with a 22-carbon backbone and a single double bond originating from either the 3rd, 7th, 9th, 11th or 17th positions from the methyl end.]
Neuropoietic Cytokine	NCIT_C20392	[A family of glycoproteins that have share structural features and downstream signaling pathways with cytokines. These proteins act as paracrine or autocrine intercellular mediators to regulate neuronal growth, regeneration, survival, and differentiation.]
Clupanodonic Acid	NCIT_C68334	[A polyunsaturated very long-chain fatty acid with a 22-carbon backbone and 5 double bonds, originating from the 3rd, 6th, 9th, 12th and 15th positions from the methyl end, with all double bonds in the cis- configuration.]
Docosapentaenoic Acid	NCIT_C68347	[A polyunsaturated very long-chain fatty acid with a 22-carbon backbone and exactly 5 double bonds. There are 3 recognized isomers of docosapentaenoic acid, and double-bonds for this fatty acid can be originating from either the (3rd, 6th, 9th, 12th, and 15th), the (3rd, 7th, 10th, 14th, and 18th), or the (6th, 9th, 12th, 15th, and 18th) positions from the methyl end.]
Omega-3 Fatty Acid	NCIT_C493	[Any fatty acid that contains an unsaturated bond originating from the 3rd carbon from the methyl end. Omega-3 fatty acids do not occur naturally with chain lengths shorter than 16 carbon units.]
Heparin-Binding Neurotrophic Factor	NCIT_C20393	[Heparin-Binding Neurotrophic Factors are a family of polypeptide growth factors produced by peripheral target tissues, as well as the nervous system, that block apoptosis and promote neuronal growth, regeneration, survival, and differentiation. Many growth factors appear to temporarily and non-covalently interact with the glycosaminoglycan heparin, which may affect growth factor activity.]