Terminology Service for NFDI4Health
All terms in NCIT
| Label | Id | Description |
|---|---|---|
| Peptide Hormone Gene | NCIT_C25994 | [Peptide Hormone Genes encode Peptide Hormones, typically synthesized as larger precursor molecules from which are derived smaller active proteins that function as hormonal signals secreted by one tissue or organ and have physiological effects on other tissues or organs.] |
| Salivary Gland Ductal Papilloma | NCIT_C35839 | [A benign papillary neoplasm that arises from the salivary glands. This category includes intraductal papilloma, inverted ductal papilloma, and sialadenoma papilliferum.] |
| Benign Salivary Gland Neoplasm | NCIT_C4600 | [A non-metastasizing neoplasm that arises from the major or minor salivary glands. Representative examples include Warthin tumor, monomorphic adenoma, and pleomorphic adenoma.] |
| Papilloma | NCIT_C7440 | [A benign epithelial neoplasm that projects above the surrounding epithelial surface and consists of villous or arborescent outgrowths of fibrovascular stroma.] |
| CpG-28 Oligodeoxynucleotide | NCIT_C60806 | [A synthetic oligodeoxynucleotide containing multiple repeats of unmethylated CpG motifs (CpG ODN) with immunostimulatory activity. Upon entering the cell via endocytosis, CpG-28 activates numerous signaling transduction pathways resulting in the release of multiple cytokines. CpG-28 has immunomodulatory properties with direct activation of B-lymphocytes, dendritic and NK cells resulting in the stimulation of innate immunity and antibody-dependant cell cytotoxicity (ADCC). Additionally, this agent indirectly modulates T-cell responses though the release of cytokines (IL-12 and IFN gamma) to induce a preferential shift to the Th1 (helper) phenotype resulting in enhanced CD8+ cellular cytotoxicity.] |
| Melanin Pigment Present | NCIT_C60807 | |
| Bosutinib | NCIT_C60809 | [A synthetic quinolone derivative and dual kinase inhibitor that targets both Abl and Src kinases with potential antineoplastic activity. Unlike imatinib, bosutinib inhibits the autophosphorylation of both Abl and Src kinases, resulting in inhibition of cell growth and apoptosis. Because of the dual mechanism of action, this agent may have activity in resistant CML disease, other myeloid malignancies and solid tumors. Abl kinase is upregulated in the presence of the abnormal Bcr-abl fusion protein which is commonly associated with chronic myeloid leukemia (CML). Overexpression of specific Src kinases is also associated with the imatinib-resistant CML phenotype.] |
| BCR-ABL Inhibitor | NCIT_C155700 | [Any agent that inhibits the tyrosine kinase BCR-ABL.] |
| Receptor Tyrosine Kinase Inhibition | NCIT_C40704 | [A process that negatively regulates the intracellular catalytic activities that originate with the binding of a tyrosine kinase-associated transmembrane receptor with its cognate ligand. This process is involved in regulation of signaling related to cellular division, cellular differentiation and morphogenesis.] |
| Receptor Tyrosine Kinase | NCIT_C17660 | [A class of membrane receptors that contain protein tyrosine kinase activity. This enzymatic activity is integral to the function of the receptor as a signal transducer; the phosphorylation event alters the functional activity of its protein substrate.] |
| Signal Transduction Inhibition | NCIT_C40821 | [Any feature of a cellular signaling process which negatively regulates the further transduction of cell signaling.] |
| Salivary Gland Inverted Ductal Papilloma | NCIT_C35835 | [A very rare benign tumor of the minor salivary glands, characterized by a luminal papillary proliferation that arises at the junction of the salivary gland duct and the oral mucosal surface epithelium and expands as a nodular mass into the lamina propria. It presents as an asymptomatic mucosal swelling.] |
| Inverted Papilloma | NCIT_C3793 | [An endophytic benign papillary epithelial neoplasm that results from the invagination and proliferation of epithelial cells in the underlying stroma. Representative examples are the inverted urothelial papilloma that arises from the urinary tract and inverted Schneiderian papilloma that arises from the nasal cavity or paranasal sinuses.] |
| Salivary Gland Sialadenoma Papilliferum | NCIT_C35836 | [An uncommon exophytic papillary proliferation that involves mucosal surface epithelium and salivary duct epithelium. It is exceptional among salivary gland neoplasms because it manifests as an exophytic papillary excrescence of the mucosa, rather than as a submucosal or intraglandular mass. It most often affects the hard or soft palate. It is generally asymptomatic. -- 2003] |
| Salivary Gland Sialoblastoma | NCIT_C35837 | [A rare, congenital or perinatal, aggressive and potentially low-grade malignant, basaloid neoplasm that occurs in the major salivary glands. It typically presents as a mass over the angle of the mandible. Most involve the parotid gland.] |
| Adrenal Medullary Hyperplasia | NCIT_C35838 | |
| Adrenal Hyperplasia | NCIT_C35408 | [A congenital or acquired hyperplasia of the cells of the adrenal cortex or medulla.] |
| Carcinosarcoma of the Salivary Gland | NCIT_C35831 | [An aggressive, high grade malignant tumor that arises from the salivary gland. It is characterized by the presence of a malignant epithelial and a sarcomatous component.] |
| Malignant Mixed Tumor of the Salivary Gland | NCIT_C8025 | [A malignant tumor arising from the salivary gland. It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements.] |
| Carcinosarcoma | NCIT_C34448 | [A malignant tumor composed of a mixture of carcinomatous and sarcomatous elements.] |