Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Major Salivary Gland Cancer pN1 TNM Finding v8	NCIT_C132756	[Major salivary gland cancer with metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension and ENE(-). (from AJCC 8th Ed.)]
Major Salivary Gland Cancer pN2 TNM Finding V8	NCIT_C132757	[Major salivary gland cancer with metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension and ENE(+); or more than 3 cm but not more than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension and ENE(-), or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)]
Major Salivary Gland Cancer pN2a TNM Finding V8	NCIT_C132758	[Major salivary gland cancer with metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension and ENE(+); or a single ipsilateral node more than 3 cm but not more than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)]
Major Salivary Gland Cancer pN2b TNM Finding V8	NCIT_C132759	[Major salivary gland cancer with metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension and ENE(-). (from AJCC 8th Ed.)]
HMGA Family Protein	NCIT_C20325	[Members of this family of high mobility group (HMG) proteins participate in a wide variety of nuclear processes ranging from chromosome and chromatin mechanics to acting as architectural transcription factors that regulate the expression of numerous genes. As a consequence, they function in the cell as highly connected nodes of protein-DNA and protein-protein interactions that influence a diverse array of normal biological processes including growth, proliferation, differentiation and death. Each protein contains three copies of the AT-hook, that preferentially binds to the minor groove of stretches of AT-rich sequence. HMGA genes are bona fide proto-oncogenes that promote tumor progression and metastasis when overexpressed. High constitutive HMGA protein levels are among the most consistent feature observed in all types of cancers with increasing concentrations being correlated with increasing malignancy. (Review in Gene 2001 277:63-81)]
Canonical HMG Protein	NCIT_C16677	[The High Mobility Group (HMG) proteins were originally isolated from mammalian cells, named according to their electrophoretic mobility in polyacrylamide gels, and were arbitrarily classed as a specific type of non-histone proteins based on the observation that they are ubiquitous to mammalian cells, that they share certain physical properties, and that they are associated with isolated chromatin. Those mammalian proteins considered to be Canonical HMG proteins are now subdivided into 3 superfamilies: the HMGB (formerly HMG-1/-2) family, the HMGN (formerly HMG-14/-17) family, and the HMGA (formerly HMG-I/Y/C) family. Each HMG family has a characteristic functional sequence motif. (www.informatics.jax.org/mgihome/nomen/genefamilies/hmgfamily.shtml)]
HMGB Family Protein	NCIT_C20326	[The HMG-Box Family proteins are relatively abundant vertebrate DNA-binding and bending proteins that bind with structure specificity, rather than sequence specificity, and plays an architectural role in the assembly of nucleoprotein complexes. They have two homologous HMG-box DNA-binding domains connected by a short basic linker to an acidic carboxy-terminal tail that differs in length. The length (and possibly sequence) of the acidic tail may be the dominant factor in mediating the differences in properties among themselves and finely tunes the DNA-binding properties of the tandem HMG boxes, to fulfill different cellular roles. The tail is essential for structure-selective DNA-binding of the HMG boxes to DNA minicircles in the presence of equimolar linear DNA, and has little effect on the affinity for this already highly distorted DNA ligand, in contrast to binding to linear and four-way junction DNA. (J Mol Biol 2000 304:135-49)]
HMGN Family Protein	NCIT_C20327	[The high mobility group N (HMGN) proteins are a family of nuclear proteins that binds to nucleosomes, changes the architecture of chromatin, and enhances transcription and replication from chromatin templates. They typically contain an NBD (Nucleosome Binding Domain) motif, which anchors these HMG proteins to the nucleosome cores to facilitate HMG-14/-17-dependent changes in higher order chromatin structure. The intracellular organization of the HMGN (previously known as HMG-14/17) proteins is dynamic and is related to both cell-cycle and transcriptional events. These proteins roam the nucleus, perhaps as part of multiprotein complexes, and their target interactions are modulated by posttranslational modifications. Functional studies on HMGN proteins provide insights into the molecular mechanisms by which structural proteins affect DNA-dependent activities in the context of chromatin. (Trends Biochem Sci 2001 Jul;26(7):431-7)]
High Mobility Group Protein B1	NCIT_C20328	[High mobility group protein B1 (215 aa, ~25 kDa) is encoded by the human HMGB1 gene. This protein is involved in the regulation of both chromatin structure and DNA topology.]
hCdt1	NCIT_C20321
High Mobility Group Protein HMG-I	NCIT_C20322	[High mobility group protein HMG-I (107 aa, ~12 kDa) is encoded by the human HMGA1 gene. This protein plays a role in the regulation of both transcription and chromatin structure.]
High Mobility Group Protein HMG-Y	NCIT_C20323	[High mobility group protein HMG-Y (96 aa, ~11 kDa) is encoded by the human HMGA1 gene. This protein is involved in transcriptional modulation and chromatin remodeling.]
Major Salivary Gland Cancer Pathologic Primary Tumor TNM Finding v8	NCIT_C132743	[A pathologic finding about one or more characteristics of major salivary gland cancer, following the rules of the TNM AJCC v8 classification system as they pertain to staging of the primary tumor.]
High-Mobility Group Protein HMGI-C	NCIT_C20324	[High mobility group protein HMGI-C (109 aa, ~12 kDa) is encoded by the human HMGA2 gene. This protein is involved in the regulation of both mitosis and gene transcription.]
Major Salivary Gland Cancer pT4a TNM Finding v8	NCIT_C132751	[Moderately advanced major salivary gland cancer. Tumor invades skin, mandible, ear canal, and/or facial nerve. (from AJCC 8th Ed.)]
High Mobility Group Protein B2	NCIT_C20330	[High mobility group protein B2 (209 aa, ~24 kDa) is encoded by the human HMGB2 gene. This protein plays a role in DNA unwinding.]
High Mobility Group Protein HMG-R	NCIT_C20331	[High mobility group protein HMG-R (179 aa, ~20 kDa) is encoded by the human HMGA1 gene. This protein plays a role in both the remodeling of chromatin and transcriptional regulation.]
Pyloric Stenosis	NCIT_C34966	[Narrowing of the pyloric lumen caused either by hypertrophy of the surrounding muscles or tissue scarring due to a chronic peptic ulcer.]
Non-Neoplastic Stomach Disorder	NCIT_C53501	[A non-neoplastic disorder that affects the stomach. Representative examples include gastritis and ulcer.]
Major Salivary Gland Cancer pT3 TNM Finding v8	NCIT_C132749	[Major salivary gland cancer with tumor more than 4 cm in greatest dimension, and/or tumor having extraparenchymal extension. Extraparenchymal extension is clinical or macroscopic evidence of invasion of soft tissues. Microscopic evidence alone does not constitute extraparenchymal extension for classification purposes. (from AJCC 8th Ed.)]