Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
[18F]L-FMAC	NCIT_C105850	[A radioconjugate composed of 2'-deoxy-2'-18F-fluoro-5-methyl-beta-L-arabinofuranosylcytosine ([18F]L-FMAC), a L-deoxycytidine analog and high-affinity substrate for deoxycytidine kinase (DCK), labeled with fluorine F 18, with potential diagnostic activity during positron emission tomography (PET) imaging. Upon administration, [18F]L-FMAC is preferentially taken up by and accumulated in cells with high DCK levels, including tumor cells with dysregulated nucleoside metabolism. After phosphorylation by DCK, the 18F moiety can be visualized by PET imaging. As many nucleoside analog prodrugs are chemotherapeutic agents that require DCK for their phosphorylation and activation, [18F]L-FMAC can potentially be used as a marker to measure DCK activity and to predict the chemotherapeutic efficacy of DCK-dependent prodrugs. DCK, a rate-limiting enzyme in the deoxyribonucleoside salvage pathway for DNA synthesis, is overexpressed in certain solid tumors, lymphoid and myeloid malignancies and certain immune cells, such as proliferating T-lymphocytes. The L-enantiomer is less susceptible to deamination by cytidine deaminase (CDA) than the D-enantiomer and increases the stability of this radioconjugate.]
CDK/JAK2/FLT3 Inhibitor TG02 Citrate	NCIT_C105851	[An orally bioavailable citrate salt form of TG02, a multi-kinase inhibitor for cyclin dependent kinase (CDK) subtypes 1, 2, 7 and 9, Janus-associated kinase 2 (JAK2), FMS-related tyrosine kinase 3 (FLT3, FLK2, STK1), with potential antineoplastic activity. Upon oral administration, CDK/JAK2/FLT3 Inhibitor TG02 binds to and inhibits the CDK subtypes, JAK2, and FLT3. TG02 also inhibits, to a lesser extent, TYK2, TYRO3, STAT5 and P38delta. This may result in both an induction of apoptosis and an inhibition of tumor cell proliferation in cancer cells that overexpress these kinases. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival. CDKs are serine/threonine kinases that play key roles in the regulation of the cell cycle and cellular proliferation. FLT3, a class III tyrosine kinase receptor, is overexpressed or mutated in most B lineage and acute myeloid leukemias.]
PGK1 Gene	NCIT_C105852	[This gene plays a role in glycolysis.]
Septum Primum	NCIT_C34294	[A wall of cardiac tissue that forms the initial, incomplete separation of the right and left atria during early heart development in the embryo.]
Embryonic Atrium	NCIT_C34146	[A segment of the primitive heart tube in the human embryo that partially encircles the bulbus cordis, and which persists in the adult heart as the right auricular appendage.]
Ralimetinib Mesylate	NCIT_C105853	[The dimesylate salt form of LY2228820, a tri-substituted imidazole derivative and orally available, p38 mitogen-activated protein kinase (MAPK) inhibitor with potential anti-inflammatory and antineoplastic activities. Upon administration, ralimetinib inhibits the activity of p38, particularly the alpha and beta isoforms, thereby inhibiting MAPKAPK2 phosphorylation and preventing p38 MAPK-mediated signaling. This may inhibit the production of a variety of cytokines involved in inflammation, cellular proliferation and angiogenesis such as tumor necrosis factor alpha (TNFa), interleukin (IL)-1, -6 and -8, vascular endothelial growth factor, and macrophage inflammatory protein-1 alpha. Ultimately this induces apoptosis and reduces tumor cell proliferation. In addition, inhibition of the p38 MAPK pathway by LY2228820 increases the antineoplastic activity of certain chemotherapeutic agents. p38 MAPK, a serine/threonine protein kinase that is often upregulated in cancer cells, plays a crucial role in tumor cell proliferation, angiogenesis and metastasis.]
Septum Secundum	NCIT_C34295	[A thick growth on the atrial wall, located to the right of the initial septum primum in the early embryo; it forms an incomplete partition between the atria, leaving only an area at the posterosuperior part of the interatrial septum: the fossa ovalis.]
Foramen Secundum	NCIT_C34179	[An opening located in the septum primum that allows blood to flow directly between the right and left atrium, and which serves as a precursor to the interatrial septum.]
PGK1 wt Allele	NCIT_C105854	[Human PGK1 wild-type allele is located in the vicinity of Xq13.3 and is approximately 64 kb in length. This allele, which encodes phosphoglycerate kinase 1 protein, is involved in both glycolysis and gluconeogenesis. Mutation of the gene is associated with phosphoglycerate kinase 1 deficiency.]
Septum Transversum	NCIT_C34296	[A ventro-dorsal plate of mesoderm, which arises from the coelomic wall of the caudal portion of the pericardial cavity, and which is located caudal to the pericardial cavity, extending from the ventral and lateral regions of the body wall to the foregut in the early embryo; it contributes to the formation of the liver, and it is the primordium of the central tendon of the diaphragm.]
Embryonic Body Cavity	NCIT_C34147	[The primitive intraembryonic coelom which, during approximately the fourth week of gestation, divides and forms three future body cavities: pericardial, pleural, and peritoneal.]
Phosphoglycerate Kinase 1	NCIT_C105855	[Phosphoglycerate kinase 1 (417 aa, ~45 kDa) is encoded by the human PGK1 gene. This protein plays a role in glycolysis.]
Sinovaginal Bulb	NCIT_C34297	[A pair of endodermal tissue swellings of the sinusal tubercle of the posterior urogenital sinus of the early embryo, which will ultimately form the lower third of the vagina.]
CACNA1G Gene	NCIT_C105856	[This gene is involved in calcium transport.]
Secondary Brain Vesicle	NCIT_C34290	[Subdivisions of the developing embryonic neural tube, including the telencephalon, diencephalon, mesencephalon, metencephalon and the myelencephalon, that are formed by the partition of the three primary brain vesicles.]
CACNA1G wt Allele	NCIT_C105857	[Human CACNA1G wild-type allele is located in the vicinity of 17q22 and is approximately 66 kb in length. This allele, which encodes voltage-dependent T-type calcium channel subunit alpha-1G protein, plays a role in both calcium transport and membrane depolarization.]
Type II Diabetes Mellitus Pathway	NCIT_C91490
Secondary Chorionic Villus	NCIT_C34291	[The second stage of chorionic villi development, which generally occurs during the third week of embryonic development, and is characterized by the appearance of a mesenchymal core within an expanding villus.]
Chorionic Villus	NCIT_C34125	[Tiny vascular tissue projections from the membranous sac that surrounds the embryo.]
Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1G	NCIT_C105858	[Voltage-dependent T-type calcium channel subunit alpha-1G (2377 aa, ~262 kDa) is encoded by the human CACNA1G gene. This protein is involved in both membrane depolarization and calcium import.]