Terminology Service for NFDI4Health
All terms in NCIT
| Label | Id | Description |
|---|---|---|
| Celery Seed | NCIT_C73869 | |
| Autologous Glioma Cell Lysate | NCIT_C105810 | [A cell lysate derived from glioma cells with potential immunostimulatory and antineoplastic activities. Upon intradermal administration, the autologous glioma cell lysate exposes the immune system to an undefined amount of glioma-type tumor associated antigens (TAA), which may result in the induction of both specific anti-tumoral cytotoxic T lymphocytes (CTL) and antibody-dependent responses against the glioma TAA-expressing cells, resulting in glioma cell lysis.] |
| Ad-hCMV-TK | NCIT_C105811 | [A human serotype 5, replication-defective, first generation adenoviral vector, with the viral E1a and E3 protein encoding regions deleted, which is engineered to express the herpes simplex virus thymidine kinase (HSV-tk) gene under the transcriptional control of the CMV promoter. This agent, when administered in conjunction with a synthetic acyclic guanosine analogue, possesses potential antineoplastic activity. Upon administration into the peritumoral region after tumor resection, adenoviral vector encoding HSV thymidine kinase is transduced into tumor cells, and HSV-tk is expressed. Tumor cells expressing HSV-tk are sensitive to synthetic acyclic guanosine analogues. Subsequent administration of a synthetic acyclic guanosine analogue, such as valacyclovir (VCV) or ganciclovir (GCV), kills the tumor cells expressing HSV-tk. The release of tumor-associated antigens (TAA) by dying tumor cells may then stimulate an antitumor cytotoxic T lymphocyte (CTL) response, directed aganst any remaining tumor cells.] |
| Ad-hCMV-Flt3L | NCIT_C105813 | [A human serotype 5, replication-defective, first generation adenoviral vector, with the viral E1a and E3 protein encoding regions deleted, which is engineered to express the soluble, immune-mediated stimulatory gene human fms-like tyrosine kinase 3 ligand (Flt3L), under the transcriptional control of the CMV promoter, with potential immunostimulating activity. Upon administration, Ad-hCMV-Flt3L is transduced into tumor cells and Flt3L is expressed. Flt3L stimulates both the proliferation of dendritic cells (DCs) and their migration to the tumor site. Upon exposure to the tumor-associated antigens (TAA) released from dying glioma cells, which were killed by thymidine kinase-mediated valacyclovir-induced tumor cell death, the DCs initiate a specific immune response against any remaining TAA-expressing tumor cells. Flt3L is a hematopoietic growth factor and ligand for the Flt3 tyrosine kinase receptor.] |
| One Hundred | NCIT_C105814 | [A natural number greater than ninety-nine and less than one hundred-one and the quantity that it denotes.] |
| NUP98/KDM5A Fusion Gene | NCIT_C105815 | [A fusion gene that results from a chromosomal translocation t(11;12)(p15;p13) which fuses the first 13 exons of the NUP98 gene with exons 28-31 of the KDM5A gene. This fusion is associated with acute megakaryoblastic leukemia.] |
| Fusion Gene | NCIT_C28510 | [A hybrid gene created by joining portions of two different genes (to produce a new protein) or by joining a gene to a different promoter (to alter or regulate gene transcription). These can be created by chromosomal aberration or by laboratory methods.] |
| NUP98/KDM5A Fusion Protein | NCIT_C105816 | [A fusion protein encoded by the NUP98/KDM5A fusion gene. This protein is comprised of the N-terminal nucleoporin GLFG repeat domains of the nuclear pore complex protein Nup98-Nup96 protein fused to the C-terminal PHD domain of the lysine-specific demethylase 5A protein.] |
| MNX1/ETV6 Fusion Gene | NCIT_C105817 | [A fusion gene that results from a chromosomal translocation t(7;12)(q36;p13) which fuses the first exon of the MNX1 gene with exon 3 of the ETV6 gene. This aberration is associated with infant acute myeloid leukemia.] |
| Acute Myeloid Leukemia with t(7;12)(q36;p13); HLXB9-ETV6 | NCIT_C122690 | [An acute myeloid leukemia in infancy characterized by t(7;12)(q36;p13) and fusion of the homeobox gene HLXB9 (MNX1) with the ETV6 gene.] |
| MNX1/ETV6 Fusion Protein | NCIT_C105818 | [A fusion protein encoded by the MNX1/ETV6 fusion gene. This protein is comprised of the N-terminal portion of the motor neuron and pancreas homeobox protein 1 protein, including the polyalanine repeat domain, fused to most of the transcription factor ETV6 protein, including the helix-loop-helix and ETS domains.] |
| ETS Domain | NCIT_C13719 | [Usually C-terminal, the conserved ETS (Erythroblast Transformation Specific) Domain of 85-90 amino acids, rich in positively-charged and aromatic residues, binds to purine-rich DNA with a GGAA/T core. Identified in many transcription factors, many ETS-proteins modulate gene expression through protein-protein interactions with other transcriptional factors and co-factors. Most ETS-proteins are nuclear targets of RAS-MAPK signaling; some affect cell proliferation or apoptosis-related genes. Several are expressed in specific cell lineages to regulate development and differentiation. Deregulated ETS-gene expression or chimeric ETS-proteins are associated with leukemias, some tumors, invasion and metastasis. (NCI)] |
| Hibiscus sabdariffa Flower | NCIT_C73895 | |
| Hops | NCIT_C73896 | |
| Hydrastis canadensis Root | NCIT_C73897 | |
| Impatiens balsamina Leaf | NCIT_C73898 | |
| Citrus Paradisi Seed | NCIT_C73891 | |
| Bupleurum Rotundifolium Root | NCIT_C73892 | |
| Pterocarpus marsupium Leaf | NCIT_C73893 | |
| Xerophyllum asphodeloides | NCIT_C73894 |