Terminology Service for NFDI4Health
All terms in NCIT
| Label | Id | Description |
|---|---|---|
| Protein Complex Subunit | NCIT_C20184 | [Used for classifying a protein or peptide that does not have a perceptible function before it is assembled into a functional complex.] |
| Ribonucleoside-Diphosphate Reductase Large Subunit | NCIT_C21213 | [Ribonucleoside-diphosphate reductase large subunit (792 aa, ~90 kDa) is encoded by the human RRM1 gene. This protein is involved in the conversion of ribonucleotides to deoxyribonucleotides.] |
| Oxidoreductase | NCIT_C16946 | [The class of all enzymes catalyzing oxidoreduction reactions (EC class 1). The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor: acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)] |
| Calcium Binding Protein | NCIT_C21214 | [Calcium Binding Proteins typically belong to the same evolutionary family and often share an EF-hand calcium-binding domain that consists of a 12 residue loop flanked on both sides by a 12 residue alpha-helical domain; the calcium ion is coordinated with oxygen of Glu or Asp residues in a pentagonal bipyramidal configuration. Reversible binding of calcium with proteins often supports protein structure or induces an alteration of protein activity in enzymatic or cell signaling cascades. Calcium is essential for maintenance of a normal heartbeat and for normal cell functions. It also plays a role in blood coagulation and in many enzymatic processes.] |
| Calcium-Binding Domain | NCIT_C14114 | [Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both side by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1, 3, 5, 7, 9 and 12; these residues are denoted by X, Y, Z, -Y, -X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand). (From InterPro IPR002048)] |
| Jod-Basedow | NCIT_C131860 | [Iodine-induced hyperthyroidism.] |
| Protein S100-A2 | NCIT_C21215 | [Protein S100-A2 (98 aa, ~11 kDa) is encoded by the human S100A2 gene. This protein plays a role in binding to calcium and to other proteins.] |
| S100 Calcium Binding Protein | NCIT_C29924 | [A family of low molecular weight proteins that are characterized by the presence of two EF-hand calcium binding domains. These proteins form homodimers that localize either in the cytoplasm or nucleus of neural crest-derived cells and are involved in the regulation of many cellular processes such as cell cycle progression and differentiation.] |
| PIK3CA Gene | NCIT_C21220 | [This gene is involved in apoptosis, cell growth and angiogenesis.] |
| Phosphoinositol Kinase Family Gene | NCIT_C26072 | [Human Phosphoinositol Kinase Family Genes encode Phosphoinositol Kinases, enzymes that phosphorylate at various positions the inositol group in membrane-bound phosphatidylinositol, often in response to extracellular signals through G-Protein Coupled Receptors or Receptor Tyrosine Kinases. The resultant phosphoinositides act as selective membrane docking sites for signal transduction proteins with diverse PH domains. Phosphorylated inositols are released as second messengers by enzymatic cleavage of the phosphoinositides.] |
| DCK Gene | NCIT_C21221 | [This gene is involved in deoxyribonucleoside phosphorylation.] |
| Drug Resistance Process | NCIT_C16523 | [Mechanisms, functions, activities, or processes exhibited by tumors or pathogens to withstand previously toxic drugs.] |
| MAP2K1 Gene | NCIT_C21222 | [This gene plays a role in signal transduction and regulation of transcription. It is also involved in cell differentiation, growth and proliferation.] |
| Cell Proliferation | NCIT_C18081 | [Involves the growth and reproduction of similar cells by cell division, resulting in an increase in cell number.] |
| Hypogonadotropic Hypogonadism with Anosmia | NCIT_C131858 | [Hypogonadotropic hypogonadism in association with an impaired sense of smell.] |
| Stromal Hyperplasia | NCIT_C35857 | |
| Mitochondrial Diabetes | NCIT_C131859 | [Diabetes mellitus caused by mutation(s) in mitochondrial DNA .] |
| Stromal Metaplasia | NCIT_C35858 | |
| Metaplasia | NCIT_C3236 | [Transformation of a mature, normal cell or groups of mature cells to other forms of mature cells. The capacity for malignant transformation of metaplastic cells is a subject of controversy.] |
| Osseous Metaplasia | NCIT_C35859 | [Heterotopic formation of normal bone within soft tissue.] |