Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Ad5F35-LMP1/LMP2-Transduced Autologous Dendritic Cells	NCIT_C73995	[Autologous dendritic cells (DCs) transduced with the replication-deficient adenoviral vector Ad5F53 encoding the Epstein-Barr virus (EBV) transmembrane latent membrane proteins 1 and 2 (LMP1/LMP2) with potential immunostimulatory activity. Vaccination with Ad5F35-LMP1/LMP2-transduced autologous dendritic cells may stimulate a specific cytotoxic T-lymphocyte (CTL) response against LMP1- and LMP2-expressing tumor positive cells, resulting in tumor cell lysis and inhibition of tumor cell proliferation. LMP1 and LMP2 are expressed in various malignancies including nasopharyngeal cancer and EBV-positive Hodgkins disease.]
Therapeutic Autologous Dendritic Cells	NCIT_C2594	[A population of a type of antigen-presenting cell (APC), the dendritic cell (DC), harvested from a patient and grown in vitro in the presence of tumor-associated antigens (TAAs) derived from the patient's tumor (a technique known as 'pulsing') and then injected back into the patient; autologous DCs so manipulated may stimulate a specific cell-mediated antitumoral cytotoxicity. DCs derived from a patient may also be fused with the patient's tumor cells in vitro to combine sustained tumor antigen expression with the antigen-presenting and immunostimulatory capacities of DCs; when injected back into the patient, these autologous DC-tumor cell hybrids (fusion cells) may stimulate an active antitumoral immune response.]
Aglatimagene Besadenovec	NCIT_C73996	[An adenoviral vector engineered to express the herpes simplex virus thymidine kinase (HSV-tk) gene, which, when administered in conjunction with a synthetic acyclic guanosine analogue, possesses potential antineoplastic activity. Aglatimagene besadenovec is transduced into tumor cells, sensitizing tumor cells that overexpress HSV-tk to synthetic acyclic guanosine analogues. Subsequently, a low dose of a synthetic acyclic guanosine analogue such as valacyclovir (VCV) or ganciclovir (GCV) is given, which may preferentially kill tumor cells containing the adenoviral vector and overexpressing HSV-tk. Release of tumor-associated antigens (TAAs) by dying tumor cells may then stimulate an antitumor cytotoxic T lymphocyte (CTL) response.]
Adipose-Derived Regenerative Cells	NCIT_C73997	[A population of cells derived from adipose tissue with stem cell and wound repair activities. Adipose-derived regenerative cells (ADRC) consists of several cell types, such as adult stem cells, vascular endothelial cells, and vascular smooth muscle cells, among others. These cells contribute to wound repair through a variety of mechanisms by promoting blood vessel growth and blocking apoptosis. In addition, ADRC can differentiate into several tissue types, such as bone, cartilage, fat, skeletal muscle, smooth muscle and cardiac muscle.]
Non-Tumor Cell Derivative Vaccine	NCIT_C62712	[A whole cell vaccine derived neither from patient tumor cells nor tumor cell-lines.]
Anatomic Rim	NCIT_C73991	[The border, edge, or margin of an organ or a part.]
Excessive	NCIT_C73992	[Beyond normal limits; unrestrained.]
Pack Year	NCIT_C73993	[A quantification of lifetime tobacco exposure defined as (number of cigarettes smoked per day x number of years smoked)/20. One pack-year is smoking 20 cigarettes a day for one year.]
WHODAS 2.0 12-item Version Interviewer-administered - Years Studying in School or College	NCIT_C130901	[World Health Organization Disability Assessment Schedule 2.0 12-item Version Interviewer-administered (WHODAS 2.0 12-item Version Interviewer-administered) How many years in all did you spend studying in school, college or university?]
WHODAS 2.0 12-item Version Interviewer-administered - Current Marital Status	NCIT_C130902	[World Health Organization Disability Assessment Schedule 2.0 12-item Version Interviewer-administered (WHODAS 2.0 12-item Version Interviewer-administered) What is your current marital status?]
WHODAS 2.0 12-item Version Interviewer-administered - Describes Main Work Status Best	NCIT_C130903	[World Health Organization Disability Assessment Schedule 2.0 12-item Version Interviewer-administered (WHODAS 2.0 12-item Version Interviewer-administered) Which describes your main work status best?]
WHODAS 2.0 12-item Version Interviewer-administered - Standing for Long Periods	NCIT_C130904	[World Health Organization Disability Assessment Schedule 2.0 12-item Version Interviewer-administered (WHODAS 2.0 12-item Version Interviewer-administered) In the past 30 days, how much difficulty did you have in: Standing for long periods such as 30 minutes?]
ALVAC(2) Melanoma Multi-antigen Vaccine	NCIT_C73998	[A therapeutic cancer vaccine, based on a replication-defective recombinant canarypox virus (ALVAC) encoding multiple melanoma antigens, with potential immunostimulatory and antineoplastic activities. Vaccination with ALVAC(2) melanoma multi-antigen therapeutic vaccine may stimulate the host immune system to mount an immune response against antigen-expressing melanoma cells, resulting in inhibition of tumor growth and/or metastasis.]
ALVAC Vaccine	NCIT_C1479	[A derivative of the Canarypox Virus, ALVAC can infect mammalian cells but it can't replicate. Thus, it produces a self-limiting infection which does not produce symptoms or harm the host. When carrying foreign genes it will cause transient expression of protein.]
WHODAS 2.0 12-item Version Interviewer-administered - Care of Household Responsibilities	NCIT_C130905	[World Health Organization Disability Assessment Schedule 2.0 12-item Version Interviewer-administered (WHODAS 2.0 12-item Version Interviewer-administered) In the past 30 days, how much difficulty did you have in: Taking care of your household responsibilities?]
ALVAC-MART-1 Vaccine	NCIT_C73999	[A cancer vaccine containing a replication-defective recombinant canarypox virus (ALVAC), encoding an epitope of MART-1 (melanoma antigen recognized by T-cells), with potential immunostimulatory and antineoplastic activities. Upon administration, the MART-1 epitope is expressed by the ALVAC vector in ALVAC-MART-1 vaccine; a host cytotoxic T lymphocyte (CTL) response against MART-1-expressing tumor cells may follow, resulting in tumor cell lysis and decreased tumor cell proliferation.]
WHODAS 2.0 12-item Version Interviewer-administered - Learning a New Task	NCIT_C130906	[World Health Organization Disability Assessment Schedule 2.0 12-item Version Interviewer-administered (WHODAS 2.0 12-item Version Interviewer-administered) In the past 30 days, how much difficulty did you have in: Learning a new task, for example, learning how to get to a new place?]
WHODAS 2.0 12-item Version Interviewer-administered - Problem Joining Community Activities	NCIT_C130907	[World Health Organization Disability Assessment Schedule 2.0 12-item Version Interviewer-administered (WHODAS 2.0 12-item Version Interviewer-administered) In the past 30 days, how much difficulty did you have in: How much of a problem did you have joining in community activities (for example, festivities, religious or other activities) in the same way as anyone else can?]
WHODAS 2.0 12-item Version Interviewer-administered - Emotionally Affected by Health	NCIT_C130908	[World Health Organization Disability Assessment Schedule 2.0 12-item Version Interviewer-administered (WHODAS 2.0 12-item Version Interviewer-administered) In the past 30 days, how much difficulty did you have in: How much have you been emotionally affected by your health problems?]
Serum Amyloid A	NCIT_C105940	[A family of apolipoproteins that are associated with high-density lipoprotein particles in the serum. These proteins may play a role in both the acute-phase of inflammation and in cholesterol transport.]