Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
DNA Replication	NCIT_C16514	[The process by which the two strands of a DNA double helix separate, allowing each strand to act as a template for the synthesis of a complementary strand by specific base pairing. Includes autonomous but not virus replication.]
RIPK1 Gene	NCIT_C21223	[This gene plays a role in apoptosis and signal transduction.]
Anchorage-Independent Growth	NCIT_C21224	[An assay to determine the ability of cells to grow unattached to a substrate. It is an indication that the cells have been transformed.]
Cellular Assay	NCIT_C15959	[In vitro experiments conducted with intact, living cells.]
Virus-specific Cytotoxic T-lymphocytes	NCIT_C131870	[A population of cytotoxic T-lymphocytes (CTLs) specifically reactive to one or more pre-selected viruses, with potential antiviral activity. Upon infusion, after an allogeneic hematopoietic cell transplant (HCT) or in other immunodeficient states, these CTLs help reconstitute viral-specific CTL responses and kill virally infected cells, thereby inhibiting viral infection in immunocompromised patients.]
Antineoplastic Immune Cell	NCIT_C129826	[Any immune cell-based preparation that can be used or may potentially be used for its cytotoxic activity against cancer cells.]
Transforming Acidic Coiled-Coil-Containing Protein 1	NCIT_C21225	[Transforming acidic coiled-coil-containing protein 1 (805 aa, ~88 kDa) is encoded by the human TACC1 gene. This protein may be involved in cell division and histogenesis.]
Nuclear Localization Signal	NCIT_C14089	[An amino acid sequence that directs the post-translational transport of a protein to the nucleus. The sequence contains positively charged amino acids such as arginine and lysine.]
Coiled-Coil Domain	NCIT_C13967	[A domain that stabilizes alpha helices in proteins through a very efficient burial of hydrophobic side chains so that polar water molecules do not access them. As a result, the helices are quite stable. In fact, many structural proteins (keratins, tropomyosin, laminin) that have to bear considerable stress have a coiled-coil domain. Two basic essential features are common: (1) the overall secondary structure is alpha helical, (2) the hydrophobic residues are arranged on one side of the helices. The typical positioning of the hydrophobic residues in the coiled-coil domain can be often recognized from primary structure of the protein. The helices can be parallel or antiparallel. The former is common when the helices belong to different polypeptides and the latter prevails in coiled coils made up from a single polypeptide chain. The number of helices in the coil varies usually between 2 and 4.]
Nucleus	NCIT_C13197	[A body within the cell, surrounded by a membrane, within which lie the chromosomes, one or more nucleoli, combined with proteins, and exhibits mitosis.]
TACC1 Gene	NCIT_C20864	[This gene plays a role in the induction of cell division.]
HLA-A11 Positive Cells Present	NCIT_C131871	[A laboratory test result indicating the presence of HLA-A11 positive cells in a tissue sample.]
MAPK3 Gene	NCIT_C21226	[This gene is involved in signal transduction and positive regulation of the cell cycle.]
T-Cell Differentiation in the Thymus	NCIT_C19317	[The progression of T cell precursors in the thymus through many stages of maturation. These stages include regulated expression of the alpha and beta (or gamma and delta) chains of the T cell receptor, expression of both CD4 and CD8 molecules (double positive stage), down regulation to a single positive stage (CD4 or CD8), as well as allowing those thymocytes to die which are unable to bind to self MHC molecules (death by neglect), selecting those thymocytes with T Cell Receptors that are able to bind to self MHC molecules with moderate affinity (positive selection), and deleting those thymocytes having T Cell Receptors that bind with high affinity to self MHC (negative selection), before allowing mature T cells to emigrate to the periphery.]
Negative Regulation of G1 to S Transition	NCIT_C21230	[G1-S Arrest consists of cellular biochemical mechanisms, responsive to diverse governing conditions (DNA damage, contact inhibition, growth factors, etc.), that control cellular commitment at the G1 restriction point to DNA replication and the proliferative cycle. G1 to S is controlled by de/phosphorylated cyclin/CDK complexes. During G1, cycD/CDK phosphorylation of Rb/HDAC repressor permits E2F/DP1 transcription of genes that promote the G1/S switch and DNA replication. p53 induces p21 inhibition of cycD/CDK; Mdm2 inhibits p53/p21. TGF-b induces p15 inhibition of cycD/CDK. cAMP induces p27 inhibition of cycD/CDK. GSK3b induction of cycD degradation, and INK4, Kip, and Cdc25A regulate cycD/CDK activity.]
G1 to S Transition Process	NCIT_C25868	[Processes that mark, promote, and sustain the commencement of, and commitment to continue, cellular processes involved in the S phase of the cell cycle, such as replication.]
Trefoil Family	NCIT_C21231	[These proteins are encoded by members of the trefoil family genes. They are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain containing three conserved intrachain disulfide bonds. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. (NCI)]
Trefoil Motif	NCIT_C13965	[Domain found in various secretory polypeptides that has highly conserved cysteine residues that are disulfide bonded in such a way as to generate a trefoil structure (bonded 1-5, 2-4, 3-6). There are also highly conserved A, G and W residues. (The Dictionary of Cell and Molecular Biology - Online)]
Glycoprotein	NCIT_C16642	[A conjugated protein having a carbohydrate component.]
MGMT Gene	NCIT_C21232	[This gene is involved in DNA repair.]