Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Chromosome Painting	NCIT_C18154	[Refers to the hybridization of fluorescently labeled, chromosome-specific, composite probe pools to cytological preparations. It allows the visualization of individual chromosomes in metaphase or interphase cells and the identification of both numerical and structural chromosomal aberrations with high sensitivity and specificity. Chromosome painting can be applied to cross-species comparisons as well as to the study of chromosomal rearrangements. The simultaneous hybridization of multiple chromosome painting probes, each tagged with a specific fluorochrome or fluorochrome combination, has resulted in the differential color display of chromosomes, i.e. spectral or color karyotyping. (From Ried et al 1998 Hum Mol Genet 7:1619)]
Prognostic Marker	NCIT_C20069	[Genes and proteins for which the expression or presence of can help predict the course and outcome of a disease.]
RNA Polymerase	NCIT_C20076	[RNA polymerases comprise a group of enzymes that catalyze extension, one nucleotide at a time, of the 3 prime-end of an RNA strand along a complementary DNA template.]
v-sis Platelet Derived Growth Factor, Beta Polypeptide	NCIT_C20077	[v-sis Platelet Derived Growth Factor beta polypeptide is the viral homologue of PDGFB. Viral oncogenes originate from normal cellular genes by recombination between a parent nontransforming virus and host cellular DNA; the cellular genes often code for important functions in cell growth or tissue differentiation. PDGF is the major serum polypeptide mitogen for cells of mesenchymal origin and has two dissimilar subunits, A and B. The B chain has homology to SIS and is alone sufficient for mitogenesis. Most proliferating cells are programmed to undergo apoptosis unless specific survival signals are provided. PDGF promotes proliferation and inhibits apoptosis by activating the RAS/PIK3/AKT1/IKK/NFKB1 pathway, inducing putative anti-apoptotic genes. (from OMIM 190040 and NCI)]
SF-36	NCIT_C20078	[A 36 question survey for measuring health status and outcomes from the patient's point of view. Designed for use in surveys of general and specific populations, health policy evaluations, and clinical practice and research. Measures 8 health concepts: 1) Limitations in physical activities because of health problems, 2) Limitations in usual role activities because of physical health problems, 3) Bodily pain, 4) General health perceptions, 5) Vitality (energy and fatigue), 6) Limitations in social activities because of physical or emotional problems, 7) Limitations in usual role activities because of emotional problems, 8) Mental health (psychological distress and well-being).]
Administrative Supplement	NCIT_C20071	[Mechanism to fund current awardees whose research is going better than expected or who are poised to test new ideas.]
Immunophenotype	NCIT_C20072	[The characterization of a set of cells according to the antigens expressed.]
Phenotype	NCIT_C16977	[The assemblage of traits or outward appearance of an individual. It is the product of interactions between genes and between genes and the environment.]
Shiga Toxin Beta Subunit	NCIT_C20073	[The non-catalytic beta subunit of Shiga toxin may be useful as a fusion vector for induction of antigen-specific cytotoxic T lymphocyte responses.]
Bacterial Protein	NCIT_C16319	[Proteins that originated from bacteria sources.]
Telomerase Protein Component 1	NCIT_C20074	[Telomerase protein component 1 (2627 aa, ~290 kDa) is encoded by the human TEP1 gene. This protein plays a role in telomerase activity and formation of the vault riboprotein particle.]
Werner Syndrome	NCIT_C3447	[A rare, autosomal recessive syndrome caused by mutations in the WRN gene. It is characterized by the appearance of accelerated aging following puberty. It is associated with the development of diabetes mellitus, atherosclerosis, cataracts, and cancer.]
WRN Gene Mutation	NCIT_C43292
Alvin J Siteman Cancer Center	NCIT_C105620	[The Alvin J Siteman Cancer Center is dedicated to advancing new approaches to cancer prevention, diagnosis, and treatment through research. It became an NCI-designated cancer center in 2001 and achieved Comprehensive Cancer Center status in 2004. Parent institutions include Barnes-Jewish Hospital and Washington University School of Medicine. Partner institutions include St. Louis Children's Hospital and BJC Healthcare.]
NCI-Designated Comprehensive Cancer Center	NCIT_C19729	[NCI-designated Comprehensive Cancer Centers conduct research and provide services directly to cancer patients. These facilities must demonstrate expertise in each of three areas: laboratory, clinical, and behavioral and population-based research. Comprehensive Cancer Centers are expected to initiate and conduct early-phase, innovative clinical trials and to participate in the NCI's cooperative groups by providing leadership and recruiting patients for trials. Comprehensive Cancer Centers must also conduct activities in outreach and education, and provide information on advances in health care for both health care professionals and the public.]
Cancer Therapy and Research Center	NCIT_C105621	[The mission of Cancer Therapy and Research Center is to conquer cancer through research, prevention and treatment. It became an NCI-designated cancer center in 1993. It is part of UT Medicine San Antonio, the clinical practice of the School of Medicine at the UT Health Science Center.]
Dan L Duncan Cancer Center	NCIT_C105622	[The Dan L Duncan Cancer Center focuses on cancer research, patient care, training, and education. It became an NCI-designated cancer center in 2007. It is a consortium made up of Baylor College of Medicine and its three primary teaching hospital affiliates: Ben Taub Hospital, Michael E DeBakey Veterans Affairs Medical Center, and Texas Children's Hospital.]
QIDS-SR - Highest Score Sleep Items	NCIT_C130600	[Quick Inventory of Depressive Symptomatology Self-Report Version (QIDS-SR) Enter the highest score on any 1 of the 4 sleep items.]
Harold C Simmons Cancer Center	NCIT_C105623	[The Harold C Simmons Cancer Center is focused on translational cancer research. It became an NCI-designated cancer center in 2010. It is part of University of Texas Southwestern Medical Center.]
QIDS-SR - High Score Appetite or Weight Items	NCIT_C130601	[Quick Inventory of Depressive Symptomatology Self-Report Version (QIDS-SR) Enter the highest score on any 1 of the 4 appetite/weight change items.]