Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Direct Ophthalmoscopy	NCIT_C94200
Contrast Agent Administered Identifier	NCIT_C69278	[An identifier for a contrast agent that was administered.]
Viral Oncolysate	NCIT_C94201
Oncolysate	NCIT_C94202
Volume Administered	NCIT_C69279	[The amount of substance given a subject.]
Volume	NCIT_C25335	[The amount of three dimensional space occupied by an object or the capacity of a space or container.]
Lysate	NCIT_C62004	[The cellular debris and fluid produced by lysis of a cell.]
Oldenlandia diffusa	NCIT_C94203
Data and Safety Monitoring Board	NCIT_C94204
Professional Organization or Group	NCIT_C19711	[A formal group of people that exists to further a particular profession.]
Ad5-SGE-REIC/Dkk-3	NCIT_C94205	[A replication incompetent adenoviral vector type 5 (Ad5) encoding the tumor suppressor gene dickkopf-3 (DKK3; Reduced Expression in Immortalized Cells; REIC; Dickkopf WNT signaling pathway inhibitor 3), and containing the super gene expression (SGE) system, composed of the triple tandem enhancer sequences of human telomerase reverse transcriptase (hTERT), simian virus 40 (SV40) and cytomegalovirus (CMV), with potential antineoplastic activity. Upon intratumoral injection and transfection of Ad5-SGE-REIC/Dkk-3, tumor cells express REIC/DKK3 protein. This may result in the activation of c-Jun-NH2-kinase (JNK) and ultimately lead to apoptosis via Bcl2 suppression and caspase-3 activation. REIC/DKK3 is expressed by healthy cells, but expression is reduced or absent in many cancer cells due to REIC/DKK3 gene defects, and this prevents tumor cell apoptosis. Increased expression of REIC/DKK3 in cancer cells may lead to an induction of tumor cell apoptosis and a reduction in tumor cell growth, while sparing normal, healthy cells expressing endogenous REIC/DKK3. The SGE system, also called C-TSC (CMV promoter driving the triple tandem enhancer sequences of hTERT, SV40 and CMV), enhances gene expression compared to more conventional adenoviral vectors.]
Adenovirus Vaccine	NCIT_C49146	[A class of viral vaccines based on adenovirus genome which was engineered to harbor gene of therapeutic interest, and were to be used in vaccination against cancers.]
Gene Therapy Agent	NCIT_C1962	[DNA constructs or co-administered agents used in gene therapy. Gene therapy constructs are used in delivery of genetic material into cells in order to permanently correct an inherited disease or an acquired disease such as cancer.]
Anti-CD20 Monoclonal Antibody TL011	NCIT_C94206	[A monoclonal antibody directed against human CD20 with potential antineoplastic activity. Anti-CD20 monoclonal antibody TL011 specifically binds to the B cell-specific cell surface antigen CD20 antigen (MS4A1; membrane-spanning 4-domains, subfamily A, member 1), thereby potentially triggering an immune response against CD20-positive B cells, leading to B cell apoptosis. CD20 is a non-glycosylated cell surface phosphoprotein that is exclusively expressed on B cells during most stages of B cell development and is often overexpressed in B-cell malignancies.]
Anti-CD20 Monoclonal Antibody	NCIT_C141215	[Any monoclonal antibody that targets CD20.]
Lefitolimod	NCIT_C94207	[A synthetic oligonucleotide based on a proprietary double stem-loop immunomodulator design with potential immunostimulating activity. Lefitolimod binds to and activates intracellular Toll-like receptor 9 (TLR9) in monocytes/macrophages, plasmacytoidal and myeloid dendritic cells (DCs), and natural killer (NK) cells, initiating immune signaling pathways and inducing T-helper 1 cell (Th1) production leading to the production of memory T cells and a Th1-mediated immune response. By activating the immune system, MGN1703 may attack tumor associated antigen (TAAs). TLR9 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity.]
Monoclonal T-cell Receptor Anti-CD3 scFv Fusion Protein IMCgp100	NCIT_C94208	[A fusion protein containing a modified form of human T-cell receptor (TCR) specific for the gp100 antigen and fused to an anti-CD3 single-chain antibody fragment, with potential antineoplastic activity. Upon direct intratumoral administration of IMCgp100 into the melanoma lesion, the TCR moiety of this agent targets and binds to the tumor associated antigen (TAA) gp100 presented on the melanoma tumor cell; the anti-CD3 fragment moiety binds to CD3- expressing T lymphocytes, thereby selectively cross-linking tumor cells and T-lymphocytes. This may lead to the recruitment of cytotoxic T lymphocytes (CTL) to the T lymphocyte/tumor cell aggregates and result in CTL-mediated death of gp100-expressing melanoma cancer cells.]
Lossy Compressed Image	NCIT_C69270	[An image that has been encoded using a lossy compression algorithm.]
Image	NCIT_C48179	[Any record of an imaging event whether physical or electronic.]
Allogeneic Natural Killer Cell Line MG4101	NCIT_C94209	[A population of allogeneic, cytotoxic natural killer (NK) cells with potential antitumor activity. Allogeneic natural killer cell line MG4101 is derived from cells of a normal, healthy donor upon leukapheresis and activation.]