Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Total Gleason Score for Prostate Cancer	NCIT_C48602	[The value of the sum of the primary and secondary Gleason scores (range 2-10). If three patterns are identified, it is the sum of the primary pattern score and the score of the least well-differentiated pattern.]
Gleason Score for Prostate Cancer	NCIT_C28084	[The score derived from universally embraced prostate cancer grading system developed by Dr. Donald F. Gleason in 1977. The system provides a reproducible description of the glandular architecture of prostate tissue to which a pathologist assigns a score depending primarily on the microscopic patterns of cancerous glands and cell morphology. The system correlates well with behavior at the extremes: Gleason 1+1 tumors are the most well differentiated, slowly growing and rarely spread; Gleason 4+5 tumors are the most poorly differentiated, often widely metastatic at the time of diagnosis. In the commoner intermediate grade tumors, however, behavior is extremely variable.]
Oligometastasis	NCIT_C139674	[A disease state that refers to a limited number of clinically detectable metastases, an intermediate state between purely localized disease and widespread metastases.]
Primary Gleason Pattern	NCIT_C48603	[The most prevalent Gleason pattern in a prostate biopsy or prostatectomy specimen. The Gleason score is defined by adding the most prevalent (primary) and second most prevalent (secondary) patterns.]
Gleason Grading System	NCIT_C28107	[A grading system for prostatic carcinoma based on the microscopic glandular architectural patterns of the malignant epithelial cells. Nuclear atypia is not evaluated. It defines five patterns or grades which reflect decreasing differentiation.]
G2/Mitotic-Specific Cyclin-B3	NCIT_C139675	[G2/mitotic-specific cyclin-B3 (1395 aa, ~158 kDa) is encoded by the human CCNB3 gene. This protein plays a role in cell cycle regulation.]
Secondary Gleason Pattern	NCIT_C48604	[The second most prevalent Gleason pattern in a prostate biopsy or prostatectomy specimen. The Gleason score is defined by adding the most prevalent (primary) and second most prevalent (secondary) patterns.]
CIC/DUX4 Fusion Protein	NCIT_C139676	[A fusion protein encoded by the CIC/DUX4 fusion gene. This protein is comprised of the majority of the protein capicua homolog, including the DNA-binding high-mobility group (HMG)-box and 15 of 16 putative MAPK phosphorylation sites, fused to the C-terminus of double homeobox protein 4, which results in the loss of both of its DNA-binding homeodomains.]
Tertiary Gleason Pattern	NCIT_C48605	[Prostate carcinoma patterns occupying less than 5% of the tumor.]
BCOR/CCNB3 Fusion Protein	NCIT_C139677	[A fusion protein encoded by the BCOR/CCNB3 fusion gene. This protein is comprised of the BCL6 co-repressor protein, which includes its three ankyrin domains, fused to the C-terminal portion of the G2/mitotic-specific cyclin-B3, which includes its two cyclin domains.]
Stage IVB Vaginal Cancer AJCC v8	NCIT_C139670	[Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (from AJCC 8th Ed.)]
CCNB3 Gene	NCIT_C139671	[This gene plays a role in the regulation of mitosis and meiosis.]
Elliptical Skin Excision	NCIT_C48611	[A surgical procedure in which the skin is cut in a geometrical fashion resembling an ellipse.]
Skin Excision	NCIT_C51767
Minimal Deviation Melanoma	NCIT_C48612	[A melanocytic neoplasm displaying morphologic features that are intermediate between those of benign nevus and melanoma. It is characterized by a nodular architectural growth resembling a melanoma, and a loss of nevus cell maturation. The melanocytic cells forming the nodular growth are uniform, and they may display a high mitotic rate, but they do not show cytologic atypia.]
CCNB3 wt Allele	NCIT_C139673	[Human CCNB3 wild-type allele is located in the vicinity of Xp11.22 and is approximately 149 kb in length. This allele, which encodes G2/mitotic-specific cyclin-B3 protein, is involved in the progression of the cell cycle. A paracentric chromosomal inversion inv(X)(p11.4;p11.22) fuses this gene and the BCOR gene; this fusion is associated with bone sarcomas.]
Level of Sexual Desire	NCIT_C125037	[A question about an individual's level of sexual desire.]
Ability to Have An Erection	NCIT_C125038	[A question about an individual's ability to have an erection.]
Ability to Reach Orgasm	NCIT_C125039	[A question about an individual's ability to reach orgasm.]
How Big a Problem is Losing Control of Stools	NCIT_C125033	[A question about an individual's assessment of how big a problem losing control of their stools has been.]