Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Recombinant Erythropoietin	NCIT_C477	[A recombinant therapeutic agent which is chemically identical to or similar to the endogenous glycoprotein erythropoietin (Epo). Epo promotes the differentiation and maturation of hematopoietic progenitors into erythrocytes; is a mitogen and a chemoattractant for endothelial cells; stimulates activated and differentiated B-cells and enhances B-cell immunoglobulin production and proliferation; and is hypoxia-inducible. (NCI04)]
Body Weight Gain Exceeding 10 Pounds	NCIT_C125065	[A subjective response indicating that an individual has gained 10 pounds or more.]
UBE2O Gene	NCIT_C150021	[This gene is involved in the monoubiquitination of substrate proteins.]
Ubiquitin-Conjugating Enzyme Gene	NCIT_C133708	[Genes encoding enzymes that catalyze the second step in the ubiquitination reaction via the transfer of ubiquitin from E1 ubiquitin-activating enzymes to themselves.]
Monoubiquitination	NCIT_C21588	[The type of ubiquitin modification determines the functional consequences for the modified protein. Monoubiquitination does not serve as a proteasome targeting signal, but plays other distinct roles. Target proteins are monoubiquitinated on one or more lysine residues, which serve as a signal for intracellular sorting as well as endocytosis of cell-surface proteins. Monoubiquitination of cell-surface receptors serves as a signal to target them to lysosome, where they are degraded by lysosomal proteases. (From PMID and NCI)]
How Big a Problem is Your Change in Body Weight	NCIT_C125060	[A question about an individual's assessment of how big a problem their body weight change has been.]
Overall Satisfaction with Treatment Received for Prostate Cancer	NCIT_C125061	[A question about an individual's overall satisfaction with the treatment they received for their prostate cancer.]
NFKBIZ wt Allele	NCIT_C150026	[Human NFKBIZ wild-type allele is located in the vicinity of 3q12.3 and is approximately 33 kb in length. This allele, which encodes NF-kappa-B inhibitor zeta protein, is involved in the modulation of nuclear factor kappa-B-mediated gene transcription.]
NFKBIZ Gene	NCIT_C150025	[This gene plays a role in the regulation of nuclear factor kappa-B-mediated gene transcription.]
Thoracic Esophagus Adenocarcinoma	NCIT_C150027	[An adenocarcinoma that arises from the thoracic esophagus.]
Malignant Neoplasm of the Thoracic Esophagus	NCIT_C3532	[A primary or metastatic malignant neoplasm involving the thoracic region of the esophagus.]
Barrel Container	NCIT_C150028	[A large, cylindrical container, suited for liquid, solid and semi-solid pharmaceutical forms.]
Container	NCIT_C43186	[An object that can be used to hold things.]
Thoracic Esophagus Squamous Cell Carcinoma	NCIT_C150029	[A squamous cell carcinoma that arises from the thoracic esophagus.]
UBE2O wt Allele	NCIT_C150022	[Human UBE2O wild-type allele is located in the vicinity of 17q25.1 and is approximately 64 kb in length. This allele, which encodes (E3-independent) E2 ubiquitin-conjugating enzyme protein, plays a role in protein monoubiquitination.]
17q25.1	NCIT_C24979	[A chromosome band present on 17q]
(E3-Independent) E2 Ubiquitin-Conjugating Enzyme	NCIT_C150023	[(E3-independent) E2 ubiquitin-conjugating enzyme (1292 aa, ~141 kDa) is encoded by the human UBE2O gene. This protein is involved in the monoubiquitination of target proteins.]
E2 Ubiquitin-Conjugating Enzyme	NCIT_C133711	[An aminoacyltransferase that catalyzes the second step in the ubiquitination reaction via the transfer of activated ubiquitin from an E1 ubiquitin-activating enzyme to itself via transthioesterification.]
Ceftolozane	NCIT_C150024	[A semi-synthetic, broad-spectrum, fifth-generation cephalosporin antibiotic with bactericidal activity against certain Gram-negative and Gram-positive bacteria. Upon administration, ceftolozane binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. This interferes with the final transpeptidation step required to form peptidoglycan chain cross-links, which are a key component of and provide strength and rigidity to the bacterial cell wall. This inhibits bacterial cell wall synthesis and reduces cell wall stability, which weakens the bacterial cell wall and causes bacterial cell lysis.]
Cephalosporin Antibiotic	NCIT_C357	[A synthetic or semi-synthetic beta-lactam antibiotic derived from Acremonium (Cephalosporium) fungi with bactericidal activity. Cephalosporin antibiotics bind to and inactivate penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.]