Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
HLA-A*2402-Restricted CDCA1-A24-56 Peptide Vaccine	NCIT_C94223	[A cancer vaccine containing the HLA-A2402-restricted peptide epitope derived from cell division associated gene 1 (CDCA1), with potential immunostimulatory and antitumor activities. Upon administration, HLA-A2402-restricted CDCA1-A24-56 peptide vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against CDCA1-expressing tumor cells, resulting in tumor cell lysis and decreased tumor cell proliferation. HLA-A2402 is an MHC class I molecule that presents antigenic peptides to CD8+ T cells; epitope design restricted to epitopes that bind most efficiently to HLA-A2402 may improve antigenic peptide immunogenicity.]
BRAF Inhibitor ARQ 736	NCIT_C94224	[An orally bioavailable, highly soluble phosphate prodrug of B-raf (BRAF) protein kinase with potential antineoplastic activity. BRAF inhibitor ARQ 736 is converted into its active form ARQ 680 in the presence of phosphatases. In turn, ARQ 680 selectively binds to and inhibits the activity of oncogenic B-raf, which may inhibit the proliferation of tumor cells expressing mutated B-raf gene. B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. The valine to glutamic acid substitution at residue 600 (V600E) accounts for about 90% of BRAF gene mutations.]
BRAF Inhibitor	NCIT_C155322	[Any agent that inhibits the serine/threonine-protein kinase BRAF(B-RAF).]
HDAC inhibitor CG200745	NCIT_C94225	[A histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. CG200745 inhibits the catalytic activity of HDAC, resulting in an accumulation of highly acetylated chromatin histones, followed by the induction of chromatin remodeling and an altered pattern of gene expression. In particular, this agent enhances the histone acetylation of the tumor suppressor gene p53. This results in an accumulation of p53, p53-dependent transactivation and apoptosis in tumor cells. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins.]
Histone Deacetylase Inhibitor	NCIT_C1946	[Any substance that inhibits histone deacetylase, an enzyme that catalyzes the removal of acetyl groups from core histones. Inhibition of histone deacetylase can result in hyperacetylation of histones, with an effect on gene expression and cell differentiation.]
Improvement	NCIT_C94226	[A condition superior to an earlier condition.]
Objective Improvement	NCIT_C94227
Subjective Improvement	NCIT_C94228
Radiopharmaceutical Volume Administered	NCIT_C69290	[The amount of radiopharmaceutical given to a subject.]
Anecdotal Report	NCIT_C94229
Report	NCIT_C25375	[A short textual account; having provided a short account.]
Radionuclide Total Dose	NCIT_C69291	[The total amount of radioisotope administered during a diagnostic or therapeutic event.]
Radionuclide Syringe Counts	NCIT_C69292	[The total amount of radioactive material present in a syringe prior to administration, measured as counts per minute.]
Radionuclide Residual Syringe Counts	NCIT_C69293	[The amount of radioactive material remaining in a syringe after administration, measured as counts per minute.]
Contrast Agent Name	NCIT_C69294	[The identity of the contrast agent.]
Pre-Medication	NCIT_C69295	[A medication that is administered prior to a procedure.]
Agent	NCIT_C1708	[An active power or cause (as principle, substance, physical or biological factor, etc.) that produces a specific effect.]
Difficulty Falling Asleep Score 0	NCIT_C131960	[A subjective score of 0 on a difficulty falling asleep scale that ranges from 0: No difficulty to 10: Didn't fall asleep.]
Difficulty Falling Asleep Scale	NCIT_C131957	[A scale for the subjective scoring of difficulty faling asleep that ranges from 0: No difficulty to 10: Didn't fall asleep.]
Difficulty Falling Asleep Score 1	NCIT_C131961	[A subjective score of 1 on a difficulty falling asleep scale that ranges from 0: No difficulty to 10: Didn't fall asleep.]