Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Maintenance of Manufacturing Machinery	NCIT_C139497	[Problems caused by failure to maintain manufacturing equipment used to produce the device.]
Unintended Emission	NCIT_C139490	[Problems due to unintended emission of electromagnetic energy by the device.]
Ambient Light Problem Identified	NCIT_C139491	[Device performance was affected by ambient light. This term applies to the direct effects of ambient light on the device, and to the user's ability to operate the device (e.g. to read device output).]
Contamination of Environment by Device	NCIT_C139492	[Operation of the device results in contamination of the nearby environment e.g. dust, dirt, smoke, heat or biological material.]
Environmental Pressure Problem Identified	NCIT_C139493	[Device performance was affected by the pressure, or changes in pressure, of the environment in which it was used.]
HomoloGene	NCIT_C48819	[A system provided by the National Center for Biotechnology Information for automated detection of homologs among the annotated genes of several completely sequenced eukaryotic genomes.]
UniSTS	NCIT_C48815	[A comprehensive database of sequence tagged sites (STSs) derived from STS-based maps and other experiments providing a unified, non-redundant view of sequence tagged sites. UniSTS integrates marker and mapping data from a variety of public resources.]
Appropriate Term/Code Not Available Problem	NCIT_C139469	[The concluded cause is not adequately described by any other term.]
Renal Tumor-Reactive Autologous Peripheral Blood Lymphocyte	NCIT_C48816	[Peripheral blood lymphocytes (PBL) harvested from the blood of a renal cancer patient and exposed in vitro to renal tumor-associated antigens (TAA). Introducing these renal tumor-reactive autologous peripheral blood lymphocytes back to the same patient target tumor cells expressing these TAAs and could induce a cytotoxic T-cell-mediated immune response against renal cell cancer.]
Peripheral Blood Lymphocyte Vaccine	NCIT_C2841	[A class of vaccines with potential antineoplastic activity. Peripheral blood lymphocytes (PBL) are first harvested from a cancer patient and induced to express a particular tumor-associated antigen or multiple antigens. Autologous vaccination with activated PBL may stimulate the host immune system to produce antibodies and/or mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for the antigen(s), resulting in decreased tumor growth. (NCI04)]
Renal Tumor-Reactive Autologous Tumor Infiltrating Lymphocyte	NCIT_C48817	[Tumor infiltrating lymphocytes (TIL) harvested directly from infiltrate of a patient's renal tumor and cultured with interleukin-2 to expand the TIL cell population. Tumor infiltrating lymphocytes have specific activity against the tumor from which they are derived. Introducing these renal tumor-reactive autologous tumor infiltrating lymphocytes back into the same patient may enhance a cytotoxic T-cell-mediated immune response against the renal cancer cells.]
Adeno-Associated Virus Type 2	NCIT_C48818	[This strain of viridae is a non-pathogenic human parvovirus that is icosahedral, 20-25 nm in diameter, minus sense, and comprised of a 5 kb. single-stranded DNA genome. The virus is generally monomorphic and has been developed as a gene therapy vector for the treatment of numerous diseases. Wild-type AA-2 retains the ability to preferentially integrate its DNA into a 4 kilobase region of human chromosome 19, designated AAVS1, making it an attractive gene therapy vehicle. The virus has demonstrated anti-cancer activity by inducing apoptosis and inhibiting the growth of cancer cells.]
Parvovirus	NCIT_C14299	[A family of very small DNA viruses containing a single linear molecule of single-stranded DNA and consisting of two subfamilies: parvovirinae and densovirinae. They infect both vertebrates and invertebrates.]
Orthologous	NCIT_C48811	[Occurring in one species but corresponding to one in another species that is related via a common ancestral species.]
Insufficient Information Available	NCIT_C139465	[The information available relating to the reported event is not sufficient to identify either the manufacturer, the device, or other essential information.]
Belinostat	NCIT_C48812	[A novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase.]
Appropriate Term/Code Not Available Identified	NCIT_C139466	[Problems is not adequately described by any other term.]
Ropidoxuridine	NCIT_C48813	[An orally available 5-substituted 2-pyrimidinone-2'-deoxyribonucleoside analogue and prodrug of 5-iododeoxyuridine (IUdR), an iodinated analogue of deoxyuridine, with radiosensitizing activity. Upon oral administration, ropidoxuridine (IPdR) is efficiently converted to idoxuridine (IUdR) by a hepatic aldehyde oxidase. In turn, IUdR is incorporated into DNA during replication, thereby sensitizing cells to ionizing radiation by increasing DNA strand breaks. Compared to IUdR, ropidoxuridine is associated with a lower toxicity profile and improved anti-tumor activity.]
Nucleoside Analogue Incorporation	NCIT_C45556	[Nucleoside Analogue Incorporation involves assimilation of nucleoside or nucleotide analogues into DNA or RNA.]
DNA Strand Break	NCIT_C25830	[A DNA Strand Break involves one or more disruptions of the covalent linkages among phosphodeoxyribose moieties within the sugar-phosphate backbone in one or in both strands of a DNA molecule.]