Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Aranidipine	NCIT_C73022
Azelnidipine	NCIT_C73023
Barnidipine	NCIT_C73024
Diproteverine	NCIT_C73025
Meprotixol	NCIT_C87660
Piperidione	NCIT_C87661
Edoxudine	NCIT_C87662	[A deoxythymidine analog with activity against herpes simplex virus. Edoxudine is activated by viral thymidine kinase to the 5'-monophosphate which is further phosphorylated by cellular enzymes to the 5'-triphosphate, a competitive inhibitor of the viral-coded DNA polymerase.]
AKR/FuA	NCIT_C14667
ACR/A Mouse	NCIT_C14668
AKR/J (?)	NCIT_C14669
Oral Pancreatic Cancer Vaccine V3-P	NCIT_C150400	[An orally bioavailable, therapeutic cancer vaccine composed of the carbohydrate antigen sialyl-Lewis A (carbohydrate antigen 19-9; CA19.9; CA19-9) that is derived from pooled blood of pancreatic cancer patients, with potential immunomodulating activity. Upon oral administration of the oral pancreatic cancer vaccine V3-P, the CA19.9 antigens may stimulate the host immune system to mount a cytotoxic T-lymphocyte (CTL)-mediated immune response against pancreatic cancer cells expressing the CA19.9 antigen. CA19.9 is overexpressed on a number of different tumor cell types and plays a key role in tumor cell survival and metastasis.]
ssRNA-based Immunomodulator CV8102	NCIT_C150401	[A 547 nucleotide (nt), noncoding, uncapped single-stranded RNA (ssRNA) containing several polyU-repeats complexed with a polymeric carrier formed by disulfide-crosslinked cationic peptides, with potential immunostimulating activity. Upon intratumoral injection, the ssRNA in CV8102 activates toll-like receptors (TLRs) and retinoic acid-inducible gene I (RIG I; RIG-I; DDX58). This stimulates a T-helper type 1 cell (Th1) response, the production of a variety of pro-inflammatory cytokines and chemokines, and activates a systemic cytotoxic-T-lymphocyte (CTL)-mediated immune response against the tumor cells when simultaneously exposed to tumor-associated antigens (TAAs). The cationic carrier peptides protect the ssRNA from RNase degradation.]
Lactobacillus rhamnosus/Lactobacillus reuteri Probiotic Supplement	NCIT_C150402	[A probiotic supplement containing the bacteria Lactobacillus (L.) rhamnosus and L. reuteri, with potential restorative and protective activities. Upon oral administration of the L. rhamnosus and L. reuteri probiotic supplement, the bacteria may restore and provide balance to the microbiota in the breast tissue. This may reduce or prevent inflammation, and may protect against the invasion of harmful bacteria and infection in the breast. In addition, the bacteria may restore the natural balance of the vaginal flora. This may prevent the invasion of harmful bacteria and yeast, and may prevent bacterial and yeast infections. This supplement may also relieve symptoms such as vaginal itching, odor and discharge, and may improve vaginal discomfort.]
Anti-LAG3 Monoclonal Antibody BI 754111	NCIT_C150403	[A monoclonal antibody directed against the inhibitory receptor lymphocyte activation gene 3 protein (LAG3; LAG-3), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, the anti-LAG3 monoclonal antibody BI 754111 binds to LAG3 expressed on tumor-infiltrating lymphocytes (TILs) and blocks its binding with major histocompatibility complex (MHC) class II molecules expressed on tumor cells. This activates antigen-specific T-lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis, which leads to a reduction in tumor growth. LAG3, a member of the immunoglobulin superfamily (IgSF), is expressed on various immune cells, and negatively regulates both proliferation and activation of T-cells. Its expression on TILs is associated with tumor-mediated immune suppression.]
PTPN14 wt Allele	NCIT_C125448	[Human PTPN14 wild-type allele is located in the vicinity of 1q32.2 and is approximately 204 kb in length. This allele, which encodes tyrosine-protein phosphatase non-receptor type 14 protein, plays a role in the regulation of cellular processes that are mediated by tyrosine dephosphorylation. Deletion of the gene may be associated with choanal atresia and lymphedema (CHATLY).]
PTPN14 Gene	NCIT_C125447	[This gene is involved in protein dephosphorylation, cell migration, cell adhesion and lymphangiogenesis.]
1q32.2	NCIT_C13899	[A chromosome band present on 1q]
Tyrosine-Protein Phosphatase Non-Receptor Type 14	NCIT_C125449	[Tyrosine-protein phosphatase non-receptor type 14 (1187 aa, ~135 kDa) is encoded by the human PTPN14 gene. This protein is involved in lymphangiogenesis, cell migration, cell adhesion and protein dephosphorylation.]
T Takeda, Kyoto 1970	NCIT_C14670
PFN1 Gene	NCIT_C125444	[This gene plays a role in the regulation of actin polymerization.]