Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Gel Dosage Form	NCIT_C42934	[A semi-solid composed of a solid, three dimensional, cross linked matrix of polymers within a liquid, yielding a jelly-like material unable to flow at steady state.]
SH2B Adapter Protein 2	NCIT_C21323	[SH2B adaptor protein 2 (632 aa, ~68 kDa) is encoded by the human SH2B2 gene. This protein is involved in the modulation of receptor tyrosine kinase signaling pathways.]
Liposomal Injection Dosage Form	NCIT_C60931	[A substance composed of active and/or inert ingredient(s) encapsulated in liposomes and intended for injection.]
Injectable Dosage Form	NCIT_C42946	[A substance intended for injection.]
Adenomatous Polyposis Coli Protein 2	NCIT_C21324	[Adenomatous polyposis coli protein 2 (2303 aa, ~244 kDa) is encoded by the human APC2 gene. This protein is involved in the regulation of catenin beta-1 turnover.]
Doxorubicin/Tariquidar	NCIT_C60932
Agent Combination Indexed in Open Clinical Trials	NCIT_C61007
Doxorubicin	NCIT_C456	[An anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.]
Tariquidar	NCIT_C2246	[An anthranilamide derivative with multidrug resistance properties. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby inhibiting transmembrane transport of anticancer drugs. Inhibition of transmembrane transport may result in increased intracellular concentrations of an anticancer drug, thereby augmenting its cytotoxicity. (NCI04)]
A-Kinase Anchor Protein 9	NCIT_C21325	[A-kinase anchor protein 9 (3911 aa, ~454 kDa) is encoded by the human AKAP9 gene. This protein plays a role in the localization of signaling proteins, including protein kinases A, C and N, protein phosphatases PP1 and PP2A, phosphodiesterase 4D3, and chloride intracellular channel proteins.]
Insert Dosage Form	NCIT_C60933	[A solid or semi-solid intended for administration within the body.]
Retinal Dehydrogenase 2	NCIT_C21330	[Retinal dehydrogenase 2 (518 aa, ~57 kDa) is encoded by the human ALDH1A2 gene. This protein plays a role in retinol metabolism.]
Aflatoxin B1 Aldehyde Reductase Member 2	NCIT_C21331	[Aflatoxin B1 aldehyde reductase member 2 (359 aa, ~40 kDa) is encoded by the human AKR7A2 gene. This protein is involved in aldehyde metabolism.]
Sister Chromatid Cohesion Protein PDS5 Homolog B	NCIT_C21332	[Sister chromatid cohesion protein PDS5 homolog B (1447 aa, ~165 kDa) is encoded by the human PDS5B gene. This protein plays a role in the regulation of both mitosis and cell proliferation.]
Dilated Thin-Walled Vascular Space Formation	NCIT_C35967
Dilated Vascular Space Formation	NCIT_C51126
Intravascular Thrombus Formation	NCIT_C35968
Cavernous-Like Vascular Space Formation	NCIT_C35964
Cavernous Lymphatic Space Formation	NCIT_C35965
Cavernous Vascular Space Formation	NCIT_C49114