Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
H1-1 wt Allele	NCIT_C126424	[Human H1-1 wild-type allele is located in the vicinity of 6p21.3 and is approximately 1 kb in length. This allele, which encodes histone H1.1 protein, plays a role in the formation of nucleosomes and higher-order chromatin structures.]
6p21.3	NCIT_C13627	[A chromosome band present on 6p]
Histone H1.1	NCIT_C126425	[Histone H1.1 (215 aa, ~22 kDa) is encoded by the human H1-1 gene. This protein is involved in both DNA binding and chromatin compaction into higher order structures.]
Histone H1	NCIT_C16683	[Linker Histone H1 interacts with DNA between nucleosome units in mediating chromatin compaction into higher order structures. Histones are basic nuclear proteins responsible for the nucleosome structure of eukaryotic chromatin. Repeating nucleosome units contain two molecules each of core Histones H2A, H2B, H3, and H4 that form an octamer complex around which approximately 146 base pairs of DNA is wrapped. (NCI)]
Helifix Coil Device	NCIT_C49880	[A coil designed to allow a Helifix pacing electrode to be placed in the endocardium.]
Hepatopetal Portal Venous Flow	NCIT_C126426	[The normal pattern of blood flow towards the liver through the portal vein.]
Blood Circulation	NCIT_C16353	[The movement of blood to and from the heart and to the rest of the body's organs, tissues, and cells through the network of arteries, veins, and capillaries. (NCI)]
Estriol Measurement	NCIT_C74856	[The determination of the amount of estriol hormone present in a sample.]
Injury to Peritoneum without mention of Open Wound into Cavity	NCIT_C35248	[Trauma to the peritoneum without indication of associated damage to the skin and other internal and external tissues.]
Injury to Peritoneum	NCIT_C35488
Estrone Measurement	NCIT_C74857	[The determination of the amount of estrone hormone present in a sample.]
Injury to Peritoneum with Open Wound into Cavity	NCIT_C35249	[Trauma to the peritoneum associated with a break in the tissue that extends into the abdominal cavity.]
Central Memory T-Lymphocyte	NCIT_C126420	[Long-lived antigen-specific T-lymphocytes, which express CD4, L-selectin and CCR7. Upon subsequent exposure to their target antigen, these cells rapidly proliferate and differentiate into effector cells.]
Central Memory Immune Cell	NCIT_C122730	[A population of long-lived antigen-specific immune cells, usually T-lymphocytes expressing CD4, L-selectin and CCR7, that are maintained by the immune system. Upon subsequent exposure to their target antigen, these cells rapidly proliferate and differentiate into effector cells.]
Gastrin Measurement	NCIT_C74858	[The determination of the amount of gastrin hormone present in a sample.]
Lysine-specific Demethylase 1 Inhibitor INCB059872	NCIT_C126421	[An orally available inhibitor of lysine-specific demethylase 1 (LSD1), with potential antineoplastic activity. Upon administration, INCB059872 binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the di- and mono-methylated forms of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4, respectively, through amine oxidation. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor-suppressor genes. In addition, LSD1 demethylates mono- or di-methylated H3K9 which increases gene expression of tumor promoting genes; inhibition of LSD1 promotes H3K9 methylation and decreases transcription of these genes. Altogether, this may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. LSD1, an enzyme belonging to the flavin adenine dinucleotide (FAD)-dependent amine oxidase family, is overexpressed in certain tumor cells and plays a key role in the regulation of gene expression and in tumor cell growth and survival.]
Glucagon Measurement	NCIT_C74859	[The determination of the amount of glucagon hormone present in a sample.]
VLP-encapsulated TLR9 Agonist CMP-001	NCIT_C126422	[An agent composed of an unmethylated CpG motif-rich G10 oligonucleotide, which is an agonist of toll-like receptor 9 (TLR9), encapsulated in noninfectious virus-like particles (VLPs), with potential immunostimulating and antineoplastic activities. Upon administration of CMP-001, the VLPs are specifically taken up by and release the oligonucleotide into antigen-presenting cells (APCs), including dendritic cells (DCs). In turn, the oligonucleotide binds to and activates intracellular TLR9. This stimulates immune signaling pathways, induces the innate immune system and may promote the immune system to attack tumor cells. VLPs stimulate the immune system. TLR9, a member of the TLR family, plays a key role in both pathogen recognition and the activation of innate immunity.]
Anisocytosis	NCIT_C35266	[The presence of erythrocytes with excessive variation in size in the blood.]
Poikilocytosis	NCIT_C35267	[An increase in the number of abnormally shaped red blood cells.]