Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Esorubicin Hydrochloride	NCIT_C74943	[A hydrochloride salt of esorubicin, a derivative of the anthracycline antineoplastic antibiotic doxorubicin, with potential antineoplastic activity. Esorubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent exhibits less cardiotoxicity than the parent antibiotic doxorubicin, but may cause more severe myelosupression compared to other compounds within the anthracycline class.]
Anthracycline Antineoplastic Antibiotic	NCIT_C1594	[An antineoplastic antibiotic that is structurally similar to the benzoquinone ansamycin antibiotic geldanamycin. A geldanamycin analogue binds to HSP90, a chaperone protein that aids in the assembly, maturation, and folding of proteins. Subsequently, the function of HSP90 is inhibited, leading to the degradation and depletion of client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.]
Lipid Measurement	NCIT_C74949	[A quantitative measurement of the amount of lipids (cholesterol, lipoproteins, and triglycerides) present in a sample.]
Clinical Pathology Procedure	NCIT_C74944	[A laboratory procedure that involves the examination of blood, urine, other fluids, and stool for diagnostic or research purposes.]
Vatalanib Succinate	NCIT_C74945	[The succinate salt of vatalanib, an anilinophthalazine derivative, with antineoplastic activity. Vatalanib binds to and inhibits the protein kinase domain of vascular endothelial growth factor receptors 1 and 2; both receptor tyrosine kinases are involved in angiogenesis. This agent also binds to and inhibits related receptor tyrosine kinases, including platelet-derived growth factor (PDGF) receptor, c-Kit, and c-Fms.]
Electrolyte Measurement	NCIT_C74946	[A quantitative measurement of the amount of an electrolyte present in a sample.]
Bupropion Hydrobromide	NCIT_C74947	[The hydrobromide salt of an aminoketone with antidepressant activity. The molecular mechanism of the antidepressant effect of bupropion is unknown. This agent does not inhibit monoamine oxidase and, compared to classical tricyclic antidepressants, is a weak blocker of the neuronal uptake of serotonin and norepinephrine. Buproprion also weakly inhibits the neuronal re-uptake of dopamine.]
Antidepressant Agent	NCIT_C265	[A pharmacological agent that acts on neurotransmitter signaling pathways to alleviate the symptoms of depression.]
Cytochrome P450 2B6	NCIT_C40050	[Cytochrome P450 2B6 (491 aa, ~56 kDa) is encoded by the human CYP2B6 gene. This protein plays a role in the metabolism of steroids and pharmaceuticals.]
Inferior Myocardial Infarction by ECG Finding	NCIT_C35398	[An electrocardiographic finding of pathologic Q waves in leads III, aVF and often II, which is suggestive of myocardial infarction of the inferior wall of the left ventricle. (CDISC)]
Lung Mature B-Cell Neoplasm	NCIT_C60310	[A neoplasm that arises from mature B-lymphocytes or plasma cells in the lung. Representative examples include bronchial mucosa-associated lymphoid tissue lymphoma, diffuse large B-cell lymphoma, lymphomatoid granulomatosis, and primary pulmonary plasmacytoma.]
Mature B-Cell Neoplasm	NCIT_C27910	[A neoplasm that arises from mature B-lymphocytes or plasma cells. Representative examples include mature B-cell non-Hodgkin lymphomas, chronic lymphocytic leukemia, hairy cell leukemia, and plasma cell neoplasms.]
Lung Neoplasm	NCIT_C3200	[A benign or malignant, primary or metastatic neoplasm involving the lungs. Representative examples of benign neoplasms include adenoma, papilloma, chondroma, and endobronchial lipoma. Representative examples of malignant neoplasms include carcinoma, carcinoid tumor, sarcoma, and lymphoma.]
Posterior Myocardial Infarction by ECG Finding	NCIT_C35399	[An electrocardiographic finding in leads V1 or V2 of an initial R wave duration greater than or equal to 40 ms, R wave greater than S wave, and upright T wave, which is suggestive of myocardial infarction of the posterior wall of the left ventricle. Evidence of inferior or lateral myocardial infarction is usually also present. (CDISC)]
Rat Histopathology Diagnoses for Proliferative Changes	NCIT_C60311
Murine Experimental Organism Diagnosis	NCIT_C21637	[A condition that is relevant to either disease states or models of disease in rats or mice.]
Serum Prostate Specific Antigen Increased	NCIT_C60312
PSA Progression	NCIT_C123611	[The amount of prostate specific antigen is increased, based on pre-defined thresholds.]
Secretory Adenocarcinoma Cell	NCIT_C60313
Adenocarcinoma Cell	NCIT_C36773