Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Nephrotic Syndrome with Lesion of Endothelial Glomerulonephritis	NCIT_C35535	[A renal functional disorder characterized by proteinuria, edema, hyperlipidemia and hypoalbuminemia. It results from damage to the renal vascular filtration apparatus. It is further characterized by an inflammatory reaction in the endovascular lining of the glomerular capillaries. Sequelae may include hypertension, atherosclerosis, infection, hypercoagulablity and renal failure.]
Zalifrelimab	NCIT_C126113	[A recombinant human monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), with immune checkpoint inhibitory and antineoplastic activities. Upon administration, zalifrelimab binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily, plays a key role in the downregulation of the immune system.]
Anti-CTLA-4 Monoclonal Antibody	NCIT_C128036	[Any monoclonal antigen against the antigen cytotoxic T-lymphocyte associated protein 4 (CTLA-4; CTLA4; CD152).]
Nephrotic Syndrome with Lesion of Hypocomplementemic Glomerulonephritis	NCIT_C35536	[Nephrotic syndrome caused by glomerulonephritis associated with complement deficiency. It can result from an acute post-infectious glomerulonephritis, membranoproliferative glomerulonephritis or lupus glomerulonephritis.]
Phospholipase C Gamma	NCIT_C126114	[A family of phospholipases that are activated by receptor tyrosine kinases, bind to the non-catalytic domains of src-family protein tyrosine kinases, and catalyze the biosynthesis of second messenger signaling molecules.]
Phospholipase	NCIT_C16980	[Enzymes that catalyze the cleavage of a phospholipid molecule by the addition of water, thereby causing hydrolysis. The classification is based on the specificity of the bond cleaved. Hydrolytic activity initiates signaling cascades in the cell.]
Nephrotic Syndrome with Lesion of Persistent Glomerulonephritis	NCIT_C35537	[A renal functional disorder characterized by proteinuria, edema, hyperlipidemia and hypoalbuminemia. It results from damage to the renal vascular filtration apparatus. It is further characterized by a chronic inflammatory reaction in the glomerular capillaries. Sequelae may include hypertension, atherosclerosis, infection, hypercoagulablity and renal failure.]
Finding by Site or System	NCIT_C36278	[A term that refers to the classification of a clinical or laboratory finding according to the anatomic site or system that is involved.]
Oxygenated Hemoglobin	NCIT_C126120	[Hemoglobin where the heme group has formed a reversible complex with oxygen (O2) in the lungs. This molecule is found in the systemic arteries and transports O2 from the lungs to the tissues where it is readily released.]
Hemoglobin	NCIT_C16676	[The red respiratory protein of erythrocytes, consisting of approximately 3.8% heme and 96.2% globin (64.5 KD), which as oxyhemoglobin (HbO2) transports oxygen from the lungs to the tissues where the oxygen is readily released and HbO2 becomes Hb.]
Deoxygenated Hemoglobin	NCIT_C126121	[Hemoglobin containing a heme group that is not bound to oxygen (O2). This molecule is normally found in the systemic veins following transit through capillaries and release of O2 into the tissues. Excess deoxyhemoglobin can be associated with hypoxia.]
Salivary Gland Sebaceous Lymphadenoma	NCIT_C35555	[A rare, benign epithelial neoplasm composed of irregular proliferating nests and islands of epithelium, including solid and gland-like sebaceous elements, surrounded by lymphoid stroma. Most occur in the parotid gland. Symptoms include a progressively enlarging, painless mass. Sebaceous lymphadenocarcinoma is the malignant counterpart.]
Acute Poliomyelitis	NCIT_C35550	[An acute infectious disorder that affects the nervous system. It is caused by the poliovirus. The virus spreads by direct contact, and can be prevented by prophylaxis with the polio vaccine.]
Central Nervous System Infectious Disorder	NCIT_C27582	[An infectious process that affects the brain and/or spinal cord. Representative examples include encephalitis, poliomyelitis, arachnoiditis, and meningitis.]
KIF20B Gene	NCIT_C126126	[This gene plays a role in microtubule-based transport, cytokinesis and cell polarity.]
Intracellular Transport	NCIT_C18146	[Any subcellular or molecular event, process, or condition involved in translocation of a biological macromolecule from one site or compartment to another, entirely within a cell. (NCI)]
Cytokinesis	NCIT_C16489	[Process in which the cytoplasm of a cell is divided after nuclear division (mitosis) is complete.]
Hypoxic Ischemic Encephalopathy	NCIT_C35549	[Ischemic brain damage in which the entire brain is deprived of oxygen. It may be fatal or lead to long term disabilities including developmental delays, intellectual disability, and seizures.]
KIF20B wt Allele	NCIT_C126127	[Human KIF20B wild-type allele is located in the vicinity of 10q23.31 and is approximately 73 kb in length. This allele, which encodes kinesin-like protein KIF20B, is involved in cytokinesis, cell polarity and microtubule-based transport.]
10q23.31	NCIT_C13650	[A chromosome band present on 10q]