Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
HDAC5 wt Allele	NCIT_C49395	[Human HDAC5 wild-type allele is located within 17q21 and is approximately 47 kb in length. This allele, which encodes histone deacetylase 5 protein, plays a role in the deacetylation of lysine residues on the N-terminal region of the core histones H2A, H2B, H3 and H4. It is also involved in transcriptional repression of myocyte enhancer MEF2C.]
HDAC5 Gene	NCIT_C24466	[This gene plays a role in chromatin remodeling, repression of gene expression and control of cellular differentiation.]
BARD1 wt Allele	NCIT_C49396	[Human BARD1 wild-type allele is located in the vicinity of 2q34-q35 and is approximately 1 kb in length. This allele, which encodes BRCA1-associated RING domain protein 1, plays a role in tumor suppression, apoptosis and cellular growth.]
BARD1 Gene	NCIT_C20715	[This gene plays a role in cellular response and is susceptible to oncogenic mutations in breast and ovarian cancers.]
Phytolacca americana	NCIT_C74306
Xanthium strumarium	NCIT_C74307
HDAC2 wt Allele	NCIT_C49390	[Human HDAC2 wild-type allele is located within 6q21 and is approximately 30 kb in length. This allele, which encodes histone deacetylase 2 protein, is involved in both the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3 and H4) and the formation of transcriptional repressor complexes. Reduced expression of the HDAC2 gene is associated with chronic obstructive pulmonary disease.]
HDAC2 Gene	NCIT_C26496	[This gene is involved in chromatin remodeling, repression of gene expression and control of both cell proliferation and differentiation.]
Smilax aristolochiifolia	NCIT_C74308
HDAC3 wt Allele	NCIT_C49391	[Human HDAC3 wild-type allele is located within 5q31 and is approximately 16 kb in length. This allele, which encodes histone deacetylase 3 protein, plays a role in the both the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3 and H4) and the binding of transcription factor YY1. Deregulation of HDAC3 gene expression is associated with colon cancer.]
HDAC3 Gene	NCIT_C26497	[This gene plays a role in chromatin remodeling, repression of gene expression and modulation of both cell growth and apoptosis.]
Euphrasia stricta	NCIT_C74309
HDAC4 wt Allele	NCIT_C49392	[Human HDAC4 wild-type allele is located in the vicinity of 2q37.2 and is approximately 352 kb in length. This allele, which encodes histone deacetylase 4 protein, is involved in the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3 and H4) and interaction with myocyte enhancer factors.]
HDAC4 Gene	NCIT_C26498	[This gene is involved in chromatin remodeling, repression of gene expression and myoblast differentiation.]
Probable E3 Ubiquitin-Protein Ligase MYCBP2	NCIT_C88943	[Probable E3 ubiquitin-protein ligase MYCBP2 (4640 aa, ~510 kDa) is encoded by the human MYCBP2 gene. This protein may play a role in both the mediation of ubiquitination and the regulation of transcription.]
MYCBP2 Gene	NCIT_C88941	[This gene may play a role in both ubiquitination and transcriptional regulation.]
SNED1 Gene	NCIT_C88944	[This gene may be involved in embryonic development.]
SNED1 wt Allele	NCIT_C88945	[Human SNED1 wild-type allele is located in the vicinity of 2q37.3 and is approximately 95 kb in length. This allele, which encodes sushi, nidogen and EGF-like domain-containing protein 1, may play a role in the modulation of mesenchymal differentiation.]
Sushi, Nidogen and EGF-Like Domain-Containing Protein 1	NCIT_C88946	[Sushi, nidogen and EGF-like domain-containing protein 1 (1413 aa, ~152 kDa) is encoded by the human SNED1 gene. This protein may be involved in the regulation of embryonic tissue morphogenesis.]
Sushi Domain	NCIT_C26050	[An ~60 amino acid extracellular protein domain that contains a conserved tryptophan and four invariant cysteines (Cys), where Cys 1 and Cys 3 form one disulfide bridge and Cys 2 and Cys 4 form another. The tertiary structure for sushi domains is based on a beta-sandwich, where one face is made up of three beta-strands that are hydrogen-bonded forming a central hydrophobic triple-stranded region and the other face is comprised of two additional beta-strands.]