Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Uterus	NCIT_C12405	[A hollow, thick-walled, muscular organ located within the pelvic cavity of a woman. Within the uterus the fertilized egg implants and the fetus develops during pregnancy.]
Aqua	NCIT_C126753	[A light bluish-green to light greenish-blue color.]
Color	NCIT_C37927	[The appearance of objects (or light sources) described in terms of a person's perception of their hue and lightness (or brightness) and saturation.]
2,6-Dimethoxyquinone	NCIT_C126754	[A methoxy-substituted benzoquinone and bioactive compound found in fermented wheat germ extracts, with potential antineoplastic and immune-enhancing activity. 2,6-Dimethoxyquinone (2,6-DMBQ) inhibits anaerobic glycolysis thereby preventing cellular metabolism and inducing apoptosis. As cancer cells use the anaerobic glycolysis pathway to metabolize glucose and cancer cells proliferate at an increased rate as compared to normal, healthy cells, this agent is specifically cytotoxic towards cancer cells. In addition, 2,6-DMBQ exerts immune-enhancing effects by increasing natural killer (NK) cell and T-cell activity against cancer cells.]
Quinone Compound	NCIT_C796	[A class of organic compounds with the base structure of quinone, an aromatic benzene molecule containing a double ketone functional group.]
Type 1 Regulatory T-Cell	NCIT_C126755	[A population of CD4+, CD25-, and FoxP3- T-lymphocytes that are involved in immunotolerance. These cells secrete the immunosuppressive cytokines, tumor growth factor-beta (TGF-B) and interleukin-10, and may induce cell cycle arrest or apoptosis in effector T-cells.]
CD4-Positive T-Lymphocyte	NCIT_C12537
Peristomal Skin	NCIT_C126756	[The skin surrounding a stoma and on which the pouching system is placed.]
Oropharyngeal Poorly Differentiated Carcinoma	NCIT_C126750	[A high-grade carcinoma that arises from the oropharynx. It is characterized by the presence of malignant cells which bear minimal resemblance to the cells from which they arose.]
Oropharyngeal Carcinoma	NCIT_C9105	[Carcinoma, predominantly squamous cell, arising from the epithelial cells of the oropharynx.]
Oropharyngeal Basaloid Carcinoma	NCIT_C126751	[A high-grade variant of squamous cell carcinoma that arises from the oropharynx. It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading.]
Oropharyngeal Squamous Cell Carcinoma	NCIT_C8181	[A squamous cell carcinoma arising from the oropharynx. It predominantly affects adults in their fifth and sixth decades of life and is associated with alcohol and tobacco use. Human papillomavirus is present in approximately half of the cases. It is characterized by a tendency to metastasize early to the lymph nodes. When the tumor is small, patients are often asymptomatic. Physical examination may reveal erythematous or white lesions or plaques. The majority of patients present with locally advanced disease. Signs and symptoms include mucosal ulceration, pain, bleeding, weight loss, neck swelling, and difficulty speaking, chewing, and swallowing. Patients may also present with swollen neck lymph nodes without any symptoms from the oropharyngeal tumor. The most significant prognostic factors are the size of the tumor and the lymph nodes status.]
Head and Neck Basaloid Carcinoma	NCIT_C37290	[A high-grade, aggressive variant of squamous cell carcinoma that arises from the head and neck region. The most common sites of origin are pyriform sinus, epiglottis, and base of tongue. It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading. Comedonecrosis may be present.]
EGFR/HER2 Inhibitor AP32788	NCIT_C126752	[An orally available inhibitor of specific mutant forms of both human epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2; ERBB2), with potential antineoplastic activity. Upon oral administration, EGFR/HER2 inhibitor AP32788 specifically and irreversibly binds to and inhibits certain mutant forms of EGFR and HER2. This prevents EGFR- and HER2-mediated signaling and leads to cell death in EGFR mutant- and HER2 mutant-expressing tumor cells. EGFR and HER2, receptor tyrosine kinases mutated in many tumor cell types, play key roles in tumor cell proliferation and tumor vascularization.]
CHEK2 Gene	NCIT_C40965	[This gene plays a role in cell survival and the negative regulation of cell growth.]
Brain Neoplasm	NCIT_C2907	[A benign or malignant neoplasm that arises from or metastasizes to the brain.]
Prostate Neoplasm	NCIT_C3343	[A benign, borderline, or malignant neoplasm that affects the prostate gland. Representative examples include benign prostate phyllodes tumor, prostatic intraepithelial neoplasia, prostate carcinoma, and prostate sarcoma.]
Breast Neoplasm	NCIT_C2910	[A benign or malignant neoplasm of the breast parenchyma. It can originate from the ducts, lobules or the breast adipose tissue. Breast neoplasms are much more common in females than males.]
Colorectal Neoplasm	NCIT_C2956	[A benign or malignant neoplasm that affects the colon or rectum. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colorectal adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms.]
CHEK2 Gene Mutation	NCIT_C40458	[A change in the nucleotide sequence of the CHEK2 gene.]