Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Gene Deletion Abnormality	NCIT_C45583	[Loss of a DNA sequence that contains one or more genes. This typically occurs via rearrangement, whereby DNA sequences that are normally separated become joined together. A gene deletion abnormality can be either heritable or somatic.]
Colorectal Adenocarcinoma	NCIT_C5105	[The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma.]
Invasive Ductal Carcinoma, Not Otherwise Specified	NCIT_C4194	[The most common type of invasive breast carcinoma, accounting for approximately 70% of breast carcinomas. The gross appearance is usually typical with an irregular stellate outline. Microscopically, randomly arranged epithelial elements are seen. When large sheets of malignant cells are present, necrosis may be seen. With adequate tissue sampling, in situ carcinoma can be demonstrated in association with the infiltrating carcinoma. The in situ component is nearly always ductal but occasionally may be lobular or both.]
Complement Activation	NCIT_C21519	[Any physiologic process in which a protease directs the cleavage of complement components C4, C2, or factor B which then form the C3 and C5 convertases for the classical and lectin pathways, respectively. This process is involved in direct lysis of target cells, immune adherence and phagocytosis of pathogens, and recruitment and activation of immunocompetent cells.]
NRK Gene	NCIT_C88934	[This gene is involved in intracellular signaling.]
NRK wt Allele	NCIT_C88935	[Human NRK wild-type allele is located in the vicinity of Xq22.3 and is approximately 249 kb in length. This allele, which encodes Nik-related protein kinase protein, plays a role in the modulation of both protein phosphorylation and the JNK pathway. Mutation of the gene is associated with breast cancer.]
TNFR1 Signaling Pathway	NCIT_C39254
Xq22.3	NCIT_C25144	[A chromosome band present on Xq]
T-Cell Receptor Gamma Chain Alternative Reading Frame Protein Isoform 1	NCIT_C88930	[T-cell receptor gamma chain alternative reading frame protein isoform 1 (58 aa, ~7 kDa) is encoded by the human TARP gene. This protein may be involved in prostate function.]
Prostate Carcinoma	NCIT_C4863	[One of the most common malignant tumors afflicting men. The majority of carcinomas arise in the peripheral zone and a minority occur in the central or the transitional zone of the prostate gland. Grossly, prostatic carcinomas appear as ill-defined yellow areas of discoloration in the prostate gland lobes. Adenocarcinomas represent the overwhelming majority of prostatic carcinomas. Prostatic-specific antigen (PSA) serum test is widely used as a screening test for the early detection of prostatic carcinoma. Treatment options include radical prostatectomy, radiation therapy, androgen ablation and cryotherapy. Watchful waiting or surveillance alone is an option for older patients with low-grade or low-stage disease. -- 2002]
TARP Gene	NCIT_C88928	[This gene may be involved in prostate function.]
Plasmacytic Infiltrate	NCIT_C40990
Massive Sinusoidal Histiocytic Infiltrate	NCIT_C40991
Sinus Histiocytosis	NCIT_C85069	[A morphologic finding indicating the presence of histiocytic infiltrates within distended lymph node sinuses.]
Homologous Protein	NCIT_C40992	[A protein similar in structure and evolutionary origin to a protein in another species.]
S-100-Positive Neoplastic Cells Present	NCIT_C40993
Sex Distribution	NCIT_C40994	[A description of the distribution of a trait between sexes in a population; number of males and females in a given population.]
Retina Layer	NCIT_C49328	[The tissue that constitutes the retina. It is composed of the following layers: ganglion cell layer, inner limiting membrane, inner nuclear layer, inner plexiform layer, layer of the ophthalmic nerve fibers, layer of the rods and cones, neural retina, outer limiting membrane, outer nuclear layer, outer plexiform layer, and retinal pigment epithelium.]
Ocular Tissue	NCIT_C133340	[Different types of tissues from the human eye.]
Retina	NCIT_C12343	[A light-sensitive membrane that lines the back wall of the eyeball. The retina is continuous with the optic nerve and this way transmits optical images to the brain.]