Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
AKR1A1 wt Allele	NCIT_C112102	[Human AKR1A1 wild-type allele is located within 1p33-p32 and is approximately 20 kb in length. This allele, which encodes alcohol dehydrogenase [NADP(+)] protein, is involved in the reduction of biogenic and xenobiotic aldehydes.]
Calnexin	NCIT_C112103	[Calnexin (592 aa, ~68 kDa) is encoded by the human CANX gene. This protein plays a role in antigen presentation, protein folding and complex assembly.]
Chaperone	NCIT_C17764	[Cytoplasmic proteins of both prokaryotes and eukaryotes that bind to nascent or unfolded polypeptides and ensure correct folding or transport. Chaperone proteins do not covalently bind to their targets and do not form part of the finished product. Heat-shock proteins are an important sub set of chaperones. Three major families are recognised, the chaperonins (groEL and hsp60), the hsp70 family and the hsp90 family. Outside these major families are other proteins with similar functions including nucleoplasmin, secB and T-cell receptor associated protein.]
Alcohol Dehydrogenase [NADP(+)]	NCIT_C112104	[Alcohol dehydrogenase [NADP(+)] (325 aa, ~37 kDa) is encoded by the human AKR1A1 gene. This protein plays a role in the reduction of biogenic and xenobiotic aldehydes.]
Pleural Mesothelioma Clinical TNM Finding v7	NCIT_C88914	[A clinical finding about one or more characteristics of pleural mesothelioma, following the rules of the TNM AJCC v7 classification system. The clinical staging depends on imaging most frequently computed tomography (CT) and more recently FDG positron emission tomography (FDG-PET) scanning. (from AJCC 7th Ed.)]
Pleural Mesothelioma TNM Finding v7	NCIT_C88895	[A finding about one or more characteristics of pleural mesothelioma, following the rules of the TNM AJCC v7 classification system. The staging system used in the AJCC 7th edition represents an adoption of the system proposed in 1995 by the International Mesothelioma Interest Group (IMIG), which was based on updated information about the relationship between tumor T and N status and overall survival. (from AJCC 7th Ed.)]
Pleural Mesothelioma Clinical Distant Metastasis TNM Finding v7	NCIT_C88915	[A clinical finding about one or more characteristics of pleural mesothelioma, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases.]
Pleural Mesothelioma cM0 TNM Finding v7	NCIT_C88916	[Pleural mesothelioma without evidence of distant metastasis. (from AJCC 7th Ed.)]
Pleural Mesothelioma cM1 TNM Finding v7	NCIT_C88917	[Pleural mesothelioma with distant metastasis. (from AJCC 7th Ed.)]
CANX wt Allele	NCIT_C112100	[Human CANX wild-type allele is located in the vicinity of 5q35 and is approximately 53 kb in length. This allele, which encodes calnexin protein, is involved in both antigen presentation and protein folding.]
CANX Gene	NCIT_C112099	[This gene plays a role in both protein folding and antigen presentation.]
EPHX1 wt Allele	NCIT_C49357	[Human EPHX1 wild-type allele is located in the vicinity of 1q42.1 and is approximately 35 kb in length. This allele, which encodes epoxide hydrolase 1 protein, is involved in the metabolism of both arene and aliphatic epoxides. Certain allelic variants of the EPHX1 gene confer susceptibility to lymphoproliferative disorders. Specific inherited defects in this gene also cause familial hypercholanemia. An EPHX1 low-activity genotype is associated with decreased risk of lung cancer.]
EPHX1 Gene	NCIT_C26506	[This gene is involved in both the activation and detoxification of xenobiotics.]
Esophagus Partial Response GvHD	NCIT_C126717	[An NIH esophagus score that has decreased by 1 or more points.]
Partial Response in GvHD	NCIT_C126713
XIAP wt Allele	NCIT_C49358	[Human XAIP wild-type allele is located in the vicinity of Xq25 and is approximately 54 kb in length. This allele, which encodes baculoviral IAP repeat-containing protein 4, is involved in anti-apoptotic activities through caspase inhibition.]
XIAP Gene	NCIT_C20357	[This gene is involved in apoptotic regulation through caspase interaction.]
Upper GI Partial Response GvHD	NCIT_C126718	[An NIH upper GI score that has decreased by 1 or more points.]
BIRC5 wt Allele	NCIT_C49359	[Human BIRC5 wild-type allele is located in the vicinity of 17q25 and is approximately 10 kb in length. This allele, which encodes baculoviral IAP repeat-containing protein 5, is involved in the prevention of apoptotic cell death.]
BIRC5 Gene	NCIT_C20350	[This gene regulates the apoptotic pathway by manipulation of the cell cycle. BIRC5 has been associated with several cancers.]