Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Protein FAM49B	NCIT_C112090	[Protein FAM49B (324 aa, ~37 kDa) is encoded by the human FAM49B gene. This protein has an unknown function.]
No Intent to Compound 506E Drug	NCIT_C112091	[A compounder does not intend to produce a drug classified as 506E.]
Compounding from Bulk Ingredient	NCIT_C112092	[A compounder produces a drug with bulk ingredients.]
Congenital Muscular Dystrophy-Dystroglycanopathy with Mental Retardation Type B2	NCIT_C126690	[An autosomal recessive inherited congenital muscular dystrophy caused by mutations in the POMT2 gene. It is characterized by mental retardation and mild structural brain abnormalities resulting from defective glycosylation of alpha-dystroglycan.]
Rigid Spine Muscular Dystrophy 1	NCIT_C126691	[An inherited muscular dystrophy caused by mutations in the SEPN1 gene. It is characterized by severe limitation in flexion of the dorsolumbar and cervical spine, due to contracture of the spinal extensors. It leads to loss of movement of the spine and the thoracic cage.]
Chromosome 15q11-q13 Duplication Syndrome	NCIT_C126692	[A syndrome caused by duplication of chromosome 15q11-q13. It is characterized by autism, mental retardation, ataxia, seizures, developmental delays, and behavioral problems.]
BCG Tokyo-172 Strain Vaccine	NCIT_C126693	[A vaccine containing bacillus Calmette-Guerin (BCG), a live, attenuated strain of Mycobacterium bovis obtained from the Pasteur Institute in 1924, with non-specific immunoadjuvant and immunotherapeutic activities. Upon intradermal administration, BCG Tokyo-172 strain vaccine activates the immune system and enhances a specific, systemic BCG antigen immune response. This results in active immunization against tuberculosis and primes the immune system against future administered BCG antigens.]
Attenuated Bacteria Vaccine	NCIT_C62761	[Any vaccine created by reducing the virulence of bacteria but still keeping the bacteria viable (live). In the production of an attenuated vaccine, the infectious agent is altered so that it becomes harmless or less virulent. This is in contrast to those vaccines produced by "killing" the pathogen (inactivated vaccine).]
Furanocoumarin	NCIT_C112046	[A class of organic phytochemicals that consists of a furan ring fused with coumarin. Furanocoumarins are produced by plants as defensive toxins and, when ingested by humans, they can affect the metabolism of drugs by cytochrome P450 isoform CYP3A4.]
Glucosinolate	NCIT_C112047	[A class of organic compounds that are derived from a glucose that has been modified by an amino acid. These compounds are anionic sulfur-containing glucosides, produced as secondary metabolites by plants of the order Brassicales, which includes cruciferous vegetables. Glucosinolates can be toxic if ingested at high doses but lower doses are under investigation as potential tumor inhibitors.]
Glycoside Compound	NCIT_C45653	[An ester containing a sugar component (glycol) and a nonsugar (aglycone) component attached via oxygen or nitrogen bond. Hydrolysis of a glycoside yields one or more sugars.]
Delta13C	NCIT_C112048	[The ratio of the stable isotopes carbon-13 and carbon-12, reported in parts per thousand. In plant tissues, this ratio varies between those plants that utilize the C3 carbon fixation pathway and those that utilize the C4 pathway.]
Succinate Dehydrogenase	NCIT_C112049	[A heterotetrameric enzyme complex found in the inner mitochondrial membrane. This protein complex catalyzes the oxidation of succinate and reduction of ubiquinone and plays a role in both the citric acid cycle and the electron transport chain.]
Inner Mitochondrial Membrane	NCIT_C13331	[The inner mitochondrial membrane encloses a fluid-filled matrix and is elaborately folded with shelf-like cristae projecting into the matrix. The components of electron transport chain are integral part of the inner membrane.]
Electron-Transport Chain of the Respiratory Enzymes	NCIT_C32501	[A series of enzyme complexes in the inner mitochondrial membrane that transfer hydrogen ions into the intermembrane space. The activity of these enzymes creates an electrochemical gradient that is necessary for synthesis of adenosine triphosphate.]
Cell Respiration	NCIT_C17894	[A two-stage process in which molecules are oxidized to produce energy. In the first stage, glucose is converted to pyruvic acid via the glycolytic pathway. Subsequently, pyruvic acid is metabolized to ultimately yield carbon dioxide and water.]
Urolithin	NCIT_C112042	[Hydroxy-6H-dibenzo[b,d]pyran-6-one derivatives that are the products of the metabolism of ellagitannins by intestinal bacteria. The biological activity of urothilins is unknown; however, these compounds are under investigation to determine if they have a mechanism of action that is similar to other phytoestrogens.]
Heterocyclic Compound	NCIT_C542	[Organic chemicals composed of a ring structure where one or more of the atoms in the ring are not carbon.]
Prostaglandin E2	NCIT_C112043	[A prostaglandin with 2 double bonds that is generated by the action of prostaglandin E synthases on prostaglandin H2. Prostaglandin E2 is a mediator of active inflammation, and has important biologic effects including potent vasodilation, smooth muscle relaxation, stimulation of osteoclast-dependent bone resorption and induction of both pain and fever. It is also used as a vaginal suppository during labor to soften the cervix and promote uterine contractions.]
Prostaglandin E	NCIT_C157134	[A family comprised of three naturally occurring prostaglandins that are involved in the regulation of many biological functions including vasodilation, inflammation and smooth muscle cell contractility.]