Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
ACPP Antibody	NCIT_C112058	[Any immunoglobulin that recognizes prostatic acid phosphatase.]
FOLH1 Antibody	NCIT_C112059	[Any immunoglobulin that recognizes glutamate carboxypeptidase 2 (folate hydrolase 1).]
CASC1 Gene	NCIT_C112053	[This gene may play a role in the pathogenesis of certain types of cancer.]
CASC1 wt Allele	NCIT_C112054	[Human CASC1 wild-type allele is located in the vicinity of 12p12.1 and is approximately 87 kb in length. This allele, which encodes cancer susceptibility candidate protein 1, may be involved in the pathogenesis of certain types of cancer.]
BCG Antibody	NCIT_C112055	[Any immunoglobulin that recognizes Bacillus Calmette-Guerin antigen.]
Cancer Susceptibility Candidate Protein 1	NCIT_C112056	[Cancer susceptibility candidate protein 1 (716 aa, ~83 kDa) is encoded by the human CASC1 gene. This protein may play a role in the pathogenesis of certain types of cancer.]
3-Hydroxyacyl-CoA Dehydrogenase	NCIT_C112050	[A family of enzymes that oxidize (S)-3-hydroxyacyl-CoA and NAD+ and produce 3-oxoacyl-CoA, NADH, and H+. These proteins are involved in the metabolism of both fatty acids and amino acids.]
Carboxylesterase	NCIT_C112051	[A family of enzymes that hydrolyze carboxylic esters.]
Macrophage Inflammatory Protein	NCIT_C112052	[A family of CC-motif cytokines that are produced by macrophages in response to endotoxin exposure. This family has two members C-C motif chemokine 3 and C-C motif chemokine 4. These chemokines promote the inflammatory response through the activation of human granulocytes and induction of the synthesis and release of other pro-inflammatory cytokines.]
Chemokine	NCIT_C20466	[Chemokines constitute a superfamily of small (8-10 kDa), inducible, secreted, pro-inflammatory cytokines that are involved in a variety of immune and inflammatory responses as well as in viral infection. Chemokines act primarily as chemoattractants and activators of specific types of leukocytes. Some members of this family were initially identified on the basis of their biological activities (e.g., IL-8, GRO), others were discovered using subtractive hybridization (e.g., RANTES) or signal sequence trap (e.g., PBSF/SDF-1)11 cloning strategies. They attract and activate leukocytes and regulate diverse cellular systems and organs ranging from blood vessels to the central nervous system.]
ERK Inhibitor LTT462	NCIT_C126687	[An orally available inhibitor of extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon oral administration, LTT462 binds to and inhibits ERK, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in numerous tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival.]
Serine/Threonine Kinase Inhibitor	NCIT_C61074	[Any substance that inhibits serine/threonine protein kinase, an enzyme that phosphorylates the hydroxyl group of serine or threonine on various proteins in various signaling cascades. Inhibition of serine/threonine protein kinase can inhibit cell proliferation and induce apoptosis.]
Bethlem Myopathy 1	NCIT_C126688	[A usually autosomal dominant inherited movement disorder caused by mutations in the COL6A1, COL6A2, and COL6A3 genes. It is characterized by progressive muscle weakness and joint stiffness in the fingers, wrists, elbows, and ankles.]
Myopathy	NCIT_C101216	[A non-neoplastic disorder that affects the muscles. Representative examples include muscular dystrophy, metabolic myopathies, muscular atrophies, and dermatomyositis.]
Centronuclear Myopathy 1	NCIT_C126689	[A myopathy inherited in an autosomal dominant or recessive pattern, caused by mutations in the DNM2, BIN1, and TTN genes. Microscopically there is central displacement of the nucleus in muscle cells. It is characterized by muscle weakness and atrophy in the skeletal muscles.]
Congenital Structural Myopathy	NCIT_C84648	[A group of rare genetic muscle disorders characterized by hypotonia, muscle weakness, and delayed development of motor skills.]
Comparative Score -2	NCIT_C126683	[A score of -2 on a comparative scale that ranges from 3+: Very much better to -3: Very much worse.]
Comparative Score -3	NCIT_C126684	[A score of -3 on a comparative scale that ranges from 3+: Very much better to -3: Very much worse.]
Behavior Assessment System for Children, Third Edition	NCIT_C126685	[A comprehensive set of rating scales designed to facilitate the differential diagnosis and classification of a variety of emotional and behavioral disorders of children, aid in the design of treatment plans, and provide insight into an individual's thoughts and feelings. Version three incorporates additional questionnaires, scales and forms.]
Autologous MAGE-A10-specific HLA-A2-restricted TCR c796 Gene-engineered Lymphocytes	NCIT_C126686	[Human autologous T-lymphocytes transduced with a retroviral vector encoding a high-affinity T-cell receptor (TCR) specific for human leukocyte antigen (HLA)-A2-restricted, human melanoma-associated antigen A10 (MAGE-A10), clone 796 (c796), with potential antineoplastic activity. Peripheral blood mononuclear cells (PBMCs) are isolated from a patient, transduced with an anti-MAGE-A10(c796)-HLA-A2 restricted TCR, expanded ex vivo, and reintroduced into the HLA-A2-positive patient. Upon reintroduction, the autologous MAGE-A10-specific, HLA-A2-restricted TCR c796 gene-engineered lymphocytes bind to tumor cells expressing the MAGE-A10 antigen, which may induce cell death in and halt the growth of MAGE-A10-expressing cancer cells. The tumor-associated antigen MAGE-A10, a member of the MAGE-A family of cancer/testis tumor-associated antigens (CT-TAAs), is overexpressed by a variety of cancer cell types.]