Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
HPSE wt Allele	NCIT_C49414	[Human HPSE wild-type allele is located in the vicinity of 4q21.3 and is approximately 43 kb in length. This allele, which encodes heparanase protein, plays a role in the hydrolysis of heparan sulfate proteoglycans. The HSPE gene is associated with cancer progression and metastasis.]
HPSE Gene	NCIT_C24477	[This gene plays a role in the disassembly of the extracellular matrix by invading cells.]
NUDT1 wt Allele	NCIT_C49415	[Human NUDT1 wild-type allele is located within 7p22 and is approximately 9 kb in length. This allele, which encodes 7,8-dihydro-8-oxoguanine triphosphatase protein, is involved in the hydrolysis of 8-oxo-dGTP in the free nucleotide pool. Overexpression of the NUDT1 gene is associated with several types of cancer such as non-small-cell lung carcinomas, renal cell carcinomas and prostate cancer.]
NUDT1 Gene	NCIT_C49205	[This gene plays a role in the hydrolysis of oxidized nucleotides.]
RECQL5 wt Allele	NCIT_C49410	[Human RECQL5 wild-type allele is located within 17q25.2-q25.3 and is approximately 40 kb in length. This allele, which encodes ATP-dependent DNA helicase Q5 protein, plays a putative role in DNA metabolism.]
RECQL5 Gene	NCIT_C26493	[This gene plays a role in the regulation of DNA topology.]
RECQL wt Allele	NCIT_C49411	[Human RECQL wild-type allele is located within 12p12 and is approximately 32 kb in length. This allele, which encodes ATP-dependent DNA helicase Q1 protein, is putatively involved in DNA repair and/or chromosome segregation.]
RECQL Gene	NCIT_C26491	[This gene is involved in DNA unwinding and the promotion of DNA strand annealing.]
Cytidine Triphosphate	NCIT_C126896	[A cytosine derived nucleotide comprised of three phosphate groups esterified to the deoxyribose sugar moiety. Nucleotide metabolism is upregulated in cancer cells; therefore, this nucleotide could be used as a biomarker to detect the presence of cancer cells.]
Nucleotide	NCIT_C709	[A subunit of DNA or RNA consisting of a nitrogenous base (adenine, guanine, thymine, or cytosine in DNA; adenine, guanine, uracil, or cytosine in RNA), a phosphate molecule, and a sugar molecule (deoxyribose in DNA and ribose in RNA).]
Deoxypyridinoline	NCIT_C126897	[A pyridinium-derived moiety that forms crosslinks in type I collagen in bone. Urine levels of deoxypyridinoline are used as a correlative marker for bone resorption and osteoclast activity; both of these activities may be increased in certain diseases.]
2,3-Dinor-6-Ketoprostaglandin F1alpha	NCIT_C126898	[A beta-oxidation product of 6-keto prostaglandin F1 alpha (PGF1a) and the major urinary metabolite of prostaglandin I2 (prostacyclin, PGI2). 2,3-dinor-6-ketoprostaglandin F1alpha in urine is often used as a correlative marker to indirectly measure prostacyclin production.]
Prostaglandin	NCIT_C782
Anti-Hairy Cell Leukemia Antibody DBA.44	NCIT_C126899	[A mouse monoclonal antibody directed against an epitope expressed by the DEAU B-lymphoma cell line, with potential diagnostic applications ex vivo. Anti-hairy cell leukemia antibody DBA.44 detects an antigen expressed on a subpopulation of B-lymphocytes in the mantle zone of lymphoid follicles. DBA.44 reacts with the majority of lymphocytes of hairy cell leukemia (HCL).]
EGFR Exon 19 Deletion Mutation	NCIT_C126892	[In-frame deletions occurring within the exon 19-encoded part of the epidermal growth factor receptor (EGFR) kinase domain. These mutations are commonly seen in non-small cell lung cancer and are associated with increased sensitivity to EGFR tyrosine kinase inhibitors.]
EGFR Exon 19 Mutation	NCIT_C128662	[A molecular genetic abnormality indicating the presence of a mutation in exon 19 of the EGFR gene.]
Globohexaosylceramide	NCIT_C126893	[A hexasaccharide glycosphingolipid and human cancer antigen expressed on the surface of many types of tumor cells. Globohexaosylceramide (Globo H) is minimally or not expressed on healthy, normal cells; its expression on cancer cells is associated with increased proliferation and poor prognosis.]
Phospholipid	NCIT_C70561	[Phosphate-containing lipids that are a major component of all cell membranes. Most phospholipids contain a diglyceride, a phosphate group, and a simple organic molecule such as choline. Another type of phospholipid is phosphosphingolipids that contain sphingosine instead of glycerol.]
Fucosyl Monosialotetrahexosylganglioside	NCIT_C126894	[A fucosylated derivative of monosialotetrahexosylganglioside (GM1) and tumor antigen associated with small-cell lung cancer (SCLC). Fucosyl-GM1 is specifically expressed in SCLC while minimally or not expressed on healthy, normal cells; it plays a key role in tumor cell proliferation and may be a biomarker to detect the presence of these cancer cells.]
Ganglioside	NCIT_C518	[Sialoglycosphingolipids (synonym: gangliosides) are glycosphingolipids carrying one or more sialic residues. Sialic acid is the generic term for N-acetyl- or N-glycoloylneuraminic acid. Gangliosides are named as N-acetyl- (or N-glycoloyl-)neuraminosyl-(X)osylceramide, where (X) stands for the root name of the neutral oligosaccharide to which the sialosyl residue is attached; found principally in nerve tissue, spleen, and thymus; GM1 accumulates in generalized gangliosidosis; GM2 accumulates in Tay-Sachs disease.]