Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
KRT10 Gene	NCIT_C112151	[This gene plays a role in intermediate filament structure.]
Keratin, Type I Cytoskeletal 10	NCIT_C112153	[Keratin, type I cytoskeletal 10 (584 aa, ~59 kDa) is encoded by the human KRT10 gene. This protein plays a role in the structure of intermediate filaments.]
Intermediate Filament Protein	NCIT_C20694	[Encoded by Intermediate Filament Genes, diverse Intermediate Filament Proteins (including keratin filaments, neurofilaments, desmin, and vimentin) form polymeric structural cytoplasmic filaments, intermediate in diameter (8-10 nanometer) between actin microfilaments and microtubules, that comprise part of the cytoskeleton of most eukaryotic cells. (NCI)]
Keratin Filament	NCIT_C13368	[A class of intermediate filaments that form a network within epithelial cells and anchor to desmosomes, thus imparting tensile strength to the tissue]
Cytokeratin	NCIT_C20693	[Cytokeratins are a family of cysteine-rich fibrous structural proteins that form tough filaments or sheets. These proteins are the main component of intermediate filaments in the epidermis, hair, nails, horny tissues, and the organic matrix of tooth enamel.]
Glycosyltransferase Gene	NCIT_C26147	[Genes that encode the class of enzymes that catalyze the transfer of glycosyl groups to an acceptor; often another carbohydrate molecule, a protein, or inorganic phosphate. Some enzymes in this class catalyze hydrolysis - the transfer of a glycosyl group to water. Subclasses include Hexosyltransferases, Pentosyltransferases, and Sialyltransferases. (NCI)]
C1GALT1 wt Allele	NCIT_C112155	[Human C1GALT1 wild-type allele is located in the vicinity of 7p21.3 and is approximately 92 kb in length. This allele, which encodes glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 protein, plays a role in mucin-type O-glycan metabolism.]
Filaggrin	NCIT_C112150	[Filaggrin (4061 aa, ~435 kDa) is encoded by the human FLG gene. This protein is involved in the structure of intermediate filaments.]
Intermediate Filament Gene	NCIT_C30073	[Intermediate Filament Genes encode a number of different Intermediate Filament Proteins (including keratin filaments, neurofilaments, desmin, and vimentin) that form polymeric structural cytoplasmic filaments, intermediate in diameter (8-10 nanometer) between actin microfilaments and microtubules, which comprise part of the cytoskeleton of most eukaryotic cells. (NCI)]
Slit Homolog 3 Protein	NCIT_C126790	[Slit homolog 3 protein (1523 aa, ~168 kDa) is encoded by the human SLIT3 gene. This protein plays a role in the modulation of cell migration.]
Ruxolitinib Phosphate Cream	NCIT_C126791	[A topical cream formulation containing the phosphate salt form of ruxolitinib, a bioavailable Janus-associated kinase (JAK) inhibitor, with potential immunomodulating activity. Upon topical administration of the ruxolitinib phosphate cream, ruxolitinib specifically binds to and inhibits the protein tyrosine kinases JAK 1 and 2; this inhibits signal transduction pathways of various cytokines and reduces inflammation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling pathways initiated by many cytokines and growth factors; JAK kinases are upregulated in various inflammatory and autoimmune diseases, including alopecia areata.]
Busulfan/Melphalan Regimen	NCIT_C126792	[A chemotherapeutic regimen composed of busulfan and melphalan used as a conditioning regimen for stem cell transplantation (SCT).]
Chemo/immuno/hormone Therapy Regimen	NCIT_C62634	[Any regimen that can be used for the treatment of cancer and non-neoplastic disease.]
Melphalan	NCIT_C633	[A phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells.]
Busulfan	NCIT_C321	[A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. (NCI04)]
Large	NCIT_C49508	[Of considerable or relatively great size, extent, or capacity.]
Bulbar Conjunctivitis	NCIT_C112189	[Inflammation of the thin layer of tissue lining the sclera of the eye characterized by redness in the white portion of the eye.]
CDKN1B wt Allele	NCIT_C49509	[Human CDKN1B wild-type allele is located within 12p13.1-p12 and is approximately 5 kb in length. This allele, which encodes cyclin-dependent kinase inhibitor 1B protein, plays a role in the progression of the cell cycle at the G1 phase.]
CDKN1B Gene	NCIT_C20060	[This gene is involved in cell cycle regulation and cyclin regulation.]
Dose Not Changed	NCIT_C49504	[An indication that a medication schedule was continued without modification.]