Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
CDKN1C Gene	NCIT_C18371	[This gene plays a regulatory role in the cell cycle.]
Acral Erythema	NCIT_C112180	[Reddening of the palmar and plantar regions of the body with occasional involvement of the distal extremities.]
Autologous Tumor-associated Peptide Antigen-pulsed Dendritic Cell Vaccine	NCIT_C126797	[A dendritic cell (DC)-based cancer vaccine composed of autologous DCs pulsed with specific tumor-associated peptide antigens (TAPA), with potential immunostimulatory and antineoplastic activities. Upon administration, autologous TAPA-pulsed DC vaccine exposes the immune system to the specific TAPAs, which may result in cytotoxic T-lymphocyte (CTL)-mediated immune responses against the TAPA-expressing cancer cells. This leads to cancer cell lysis. This vaccine is specific towards peptides derived from the following proteins: sperm autoantigenic protein 17 (SP17), ropporin, A-kinase anchor protein 4 (AKAP4), pituitary tumor-transforming 1 (PTTG1) and SPANX family member B (SPANX-B).]
Pol I Inhibitor CX5461	NCIT_C126798	[An orally bioavailable inhibitor of RNA polymerase I (Pol I), with potential antineoplastic activity. Upon oral administration, CX-5461 selectively binds to and inhibits Pol I, prevents Pol I-mediated ribosomal RNA (rRNA) synthesis, induces apoptosis, and inhibits tumor cell growth. Pol I, the multiprotein complex that synthesizes rRNA, is upregulated in cancer cells and plays a key role in cell proliferation and survival. Hyperactivated rRNA transcription is associated with uncontrolled cancer cell proliferation.]
Anti-PD-1 Monoclonal Antibody TSR-042	NCIT_C126799	[A humanized monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 (PD-1; programmed death-1), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-PD-1 monoclonal antibody TSR-042 binds to and inhibits PD-1 and its downstream signaling pathways. This may restore immune function through the activation of T-cells. PD-1, a transmembrane protein in the Ig superfamily expressed on T-cells, functions as an immune checkpoint protein that negatively regulates T-cell activation and T-cell-mediated immune responses when activated by its ligands programmed cell death receptor ligand 1 (PD-L1) or 2 (PD-L2); it plays an important role in tumor evasion from host immunity.]
Anti-PD1 Monoclonal Antibody	NCIT_C128037	[A monoclonal antibody directed against programmed cell death protein 1 (PD-1; PD1; CD279).]
Kava-based Supplement	NCIT_C126793	[A Kava supplement derived from Piper methysticum, with potential cancer preventative activity. Upon oral administration, the kava-based supplement may affect the metabolism of certain carcinogens, presumably because of the kavalactones present in this product.]
Anti-LGR5 Monoclonal Antibody BNC101	NCIT_C126794	[A humanized monoclonal antibody targeting leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), with potential antineoplastic activity. Upon administration, the anti-LGR5 humanized monoclonal antibody BNC101 targets and binds to LGR5, thereby inhibiting LRG5-mediated signal transduction pathways. This prevents proliferation of LRG5-expressing tumor cells. LGR5, a member of the Wnt signaling pathway, is a cancer stem cell (CSC) receptor overexpressed on certain cancer cells; it plays a key role in CSC proliferation and survival.]
Wu-ling-San	NCIT_C126795	[A traditional Chinese medicine (TCM) composed of Polyporus sclerotium (Sclerotium polypori Umbrellati; Zhu Ling), Sclerotium Poriae Cocos (Poria; Fu Ling), Alismatis rhizome (Alisma; Rhizoma Alismatis Orientalis; Ze Xie), Cinnamomi cortex (Ramulus Cinnamomi Cassiae; Gui Zhi) and Atractylodis macrocephalae rhizome (Rhizoma Atractylodis Macrocephalae; Bai Zhu) with potential diuresis-inducing and kidney protective activities. Upon oral administration, wu-ling san may increase the removal of excess fluid, prevent the retention of water, maintain healthy water metabolism by promoting diuresis, and protect kidney function.]
Agent Affecting Blood or Body Fluid	NCIT_C78275	[An agent that exerts an effect on the synthesis or function of blood, blood components or body fluids.]
Balanced Crystalloid Solution	NCIT_C126796	[A multiple electrolyte, isotonic, crystalloid solution for intravenous infusion containing sodium chloride, sodium gluconate, sodium acetate, potassium chloride and magnesium chloride, which can restore electrolyte balance, normalize pH, and provide hydration. Upon intravenous administration, the balanced crystalloid solution will replace lost body fluids and electrolytes thereby providing hydration, normalizing electrolyte concentrations and regulating acid-base balance.]
Fluorine F 18 Galacto-RGD Peptide	NCIT_C112178	[A radiotracer composed of a cyclic Arg-Gly-Asp (RGD) peptide that is conjugated with galactose and radiolabeled with fluorine 18, for potential noninvasive positron emission tomography (PET) imaging of alphaVbeta3 integrin expression. Upon administration, the RGD moiety of the fluorine 18 galacto-RGD peptide selectively binds to alphaVbeta3 integrin. During PET imaging, alphaVbeta3-expressing tumor cells can be visualized and the degree of tumor angiogenesis can be determined. Use of a hydrophilic glycopeptide-based agent may increase retention in the blood and reduce clearance by the liver. This leads to both increased uptake of fluorine 18 galacto-RGD peptide by tumor cells and enhanced PET imaging efficiency, when compared to other agents that are constructed using lipophilic conjugates. AlphaVbeta3 integrin, a cell adhesion and signaling receptor, is upregulated in tumor vessel endothelial cells and has been associated with proliferation of tumor cells, tumor angiogenesis and metastasis.]
Anti-CD19-CAR-CD3zeta-4-1BB-Expressing Allogenic Natural Killer Cells	NCIT_C112179	[Allogeneic natural killer (NK) cells transduced with an mRNA expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) and the zeta chain of the TCR/CD3 complex (CD3-zeta), coupled to the signaling domain of 4-1BB (CD137), with potential immunomodulating and antineoplastic activities. NK cells from haploidentical donors are expanded in culture and electroporated with the CAR mRNA. Upon transfusion of the transduced cultured cells, CD19CAR-CD3zeta-4-1BB-expressing allogeneic NK cells bind to and induce selective cytotoxicity in CD19-expressing tumor cells. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19. Its inclusion may also increase antitumor activity, when compared to the inclusion of the CD3-zeta chain alone. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.]
Genetically-engineered Immune Cell	NCIT_C154231	[Any autologous or allogeneic immune cell that has been genetically modified.]
Skin Bruise	NCIT_C112174	[Extravasation of blood into the subcutaneous space.]
Bruise	NCIT_C37921	[Injury of the soft tissues or bone without breaking the skin that is characterized by blood leakage into the surrounding area.]
Angioedema	NCIT_C112175	[Rapid swelling of the deep layers of the skin due to transient vascular leakage of serous fluid.]
Blanching	NCIT_C112176	[Transient pallor of the skin caused by reduced blood flow to the affected region.]
Skin Discoloration	NCIT_C3327	[Abnormal skin coloration.]
HDAC Inhibitor CXD101	NCIT_C112177	[A novel histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. Although the exact therapeutic mechanism of action for CXD101 is not known, oral administration of this agent should inhibit the catalytic activity of HDAC, which results in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling and an altered pattern of gene expression. HDAC, a family of enzymes upregulated in many tumor types, deacetylates chromatin-associated histone proteins.]