Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Accessory Lacrimal Gland	NCIT_C74586	[Serous gland with distended lumen. It includes the gland of Krause in the lacrimal sac and the gland of Wolfring on the inner surface of the upper eyelid.]
Lacrimal Gland	NCIT_C12346	[Paired, almond-shaped exocrine glands situated superior and posterior to each orbit of the eye that produce and secrete the watery serous component of tears.]
Omoconazole	NCIT_C74599	[A topical imidazole derivative with antifungal activity against Candida albicans, Malassezia furfur and dematophytes.]
Antifungal Agent	NCIT_C514	[Substances that treat systemic or topical infections caused by fungi. Antifungal agents kill or inhibit the growth of fungi, by various mechanisms. These mechanisms include inhibition of fungal mitosis, impairing synthesis or binding to ergosterol, inhibition of RNA or DNA synthesis, and interfering with other fungal metabolic processes.]
Attenuated Live Listeria Encoding HPV 16 E7 Vaccine ADXS11-001	NCIT_C74595	[A cancer vaccine containing a live-attenuated strain of the bacterium Listeria monocytogenes (Lm) encoding human papillomavirus (HPV) type 16 E7 fused to a non-hemolytic listeriolysin O protein with potential immunostimulatory and antineoplastic activities. Upon vaccination, Listeria expresses the HPV 16 E7 antigen and activates the immune system to mount a cytotoxic T-lymphocyte (CTL) response against cancer cells expressing HPV 16 E7. This may result in tumor cell lysis. In addition, the Listeria vector itself may induce a potent immune response. HPV 16 E7, a cell surface glycoprotein and tumor associated antigen, is overexpressed in the majority of cervical cancer cells.]
Attenuated Live Virus Vaccine	NCIT_C1920	[Live vaccines prepared from microorganisms which have undergone physical adaptation (e.g., by radiation or temperature conditioning) or serial passage in laboratory animal hosts or infected tissue/cell cultures, in order to produce avirulent mutant strains capable of inducing protective immunity. Live-attenuated vaccines are used when a CD8+ T Cell (cellular cytotoxicity) response is desired.]
Oxytetracycline Anhydrous	NCIT_C74596
Tetracycline Antibiotic	NCIT_C1595	[Any of a group of broad spectrum naphthacene antibiotics isolated from various species of Streptomyces or produced semisynthetically. In bacteria, tetracycline antibiotics block binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis. (NCI05)]
Oxyphenbutazone Anhydrous	NCIT_C74597
Omeprazole Sodium	NCIT_C74598	[The sodium salt form of a benzimidazole with selective and irreversible proton pump inhibitor activity. In the acidic compartment of parietal cells, omeprazole is protonated and converted into the active achiral sulfenamide; the active sulfenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. H+/K+ ATPase is an integral membrane protein of the gastric parietal cell.]
Proton Pump Inhibitor	NCIT_C29723	[Any one of the substituted benzimidazole compounds with anti-ulcer activity. A proton pump inhibitor is orally administered in the neutrally charged, inactive form and, upon entering the acidic environment of the parietal cell, gets protonated and converted into its active form. The active form will covalently and irreversibly bind to the proton pump, the H+/K+-ATPase, located on the surface of parietal cells. This leads to an inhibition of the transport of hydrogen ions, in exchange for potassium ions, into the gastric lumen and results in an inhibition of gastric acid secretion.]
PTPN6 wt Allele	NCIT_C49526	[Human PTPN6 wild-type allele is located within 12p13 and is approximately 29 kb in length. This allele, which encodes tyrosine-protein phosphatase non-receptor type 6 protein, is involved in the dephosphorylation of protein-tyrosine phosphates. Aberrant methylation of the PTPN6 gene results in low expression levels in leukemias and lymphomas.]
PTPN6 Gene	NCIT_C24708	[This gene plays a role in the regulation of multiple signaling pathways in hematopoietic cells.]
CCNE2 wt Allele	NCIT_C49527	[Human CCNE2 wild-type allele is located in the vicinity of 8q22.1 and is approximately 15 kb in length. This allele, which encodes G1/S-specific cyclin-E2 protein, is involved in the regulation of the G1/S transition of the cell cycle. The expression of this allele peaks at the G1-S phase and has distinct tissue specificity.]
CCNE2 Gene	NCIT_C20958	[This gene regulates the G1/S phase of the cell cycle.]
PTPN7 wt Allele	NCIT_C49528	[Human PTPN7 wild-type allele is located in the vicinity of 1q32.1 and is approximately 15 kb in length. This allele, which encodes tyrosine-protein phosphatase non-receptor type 7 protein, plays a role in the dephosphorylation of protein-tyrosine phosphates.]
PTPN7 Gene	NCIT_C24709	[This gene plays a role in regulation of lymphocyte development and suppression of signal transduction.]
PTP4A1 wt Allele	NCIT_C49529	[Human PTP4A1 wild-type allele is located within 6q12 and is approximately 11 kb in length. This allele, which encodes protein tyrosine phosphatase type IVA protein 1, is involved in stimulating the progression from G1 to S phase during mitosis.]
PTP4A1 Gene	NCIT_C24704	[This gene is involved in liver cell growth and the cellular response to mitogens.]
PTPRE wt Allele	NCIT_C49533	[Human PTPRE wild-type allele is located within 10q26 and is approximately 179 kb in length. This allele, which encodes receptor-type tyrosine-protein phosphatase epsilon protein, is involved in the dephosphorylation of protein-tyrosine phosphates.]