Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
HSPB1 wt Allele	NCIT_C49548	[Human HSPB1 wild-type allele is located in the vicinity of 7q11.23 and is approximately 2 kb in length. This allele, which encodes heat-shock protein beta-1 protein, is involved in stress resistance responses.]
CASP1 wt Allele	NCIT_C49549	[Human CASP1 wild-type allele is located within 11q23 and is approximately 76 kb in length. This allele, which encodes caspase-1 protein, is involved in the cleavage of IL-1 beta releasing the active form of this cytokine. Loss of CASP1 gene expression is associated with prostate cancer.]
CASP1 Gene	NCIT_C26554	[This gene plays a role in apoptosis, inflammation, septic shock, and wound healing.]
CASP5 wt Allele	NCIT_C49555	[Human CASP5 wild-type allele is located within 11q22.2-q22.3 and is approximately 15 kb in length. This allele, which encodes caspase-5 protein, is involved in the mediation of apoptosis.]
CASP5 Gene	NCIT_C28433	[This gene plays a role in apoptosis, cell growth and differentiation.]
Guanine Nucleotide-Binding Protein G(s) Subunit Alpha Isoforms Short	NCIT_C126519	[Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (394 aa, ~46 kDa) is encoded by the human GNAS gene. This protein plays a role in the activation of adenylate cyclase activity.]
Heterotrimeric G Protein Subunit	NCIT_C19273	[The alpha, beta, and gamma subunits (or beta-gamma dimers) of heterotrimeric guanine nucleotide binding (G) proteins are intracellular membrane-associated proteins activated by various receptors (e.g., beta adrenergic). They serve as transducers of the receptor-initiated response linked to intracellular elements, such as enzymes, that generate second messengers to initiate an effect. These proteins have a high affinity for guanine nucleotides and hence are named "G" proteins.]
GNAS Gene Product	NCIT_C126518	[A protein encoded by the GNAS gene.]
Submission Domain	NCIT_C49556	[A collection of logically-related observations with a topic-specific commonality about the subjects in a trial, used in the regulatory submission process. The logic of the relationship may relate to the scientific subject matter of the data, or to its role in the trial. Typically, each domain is represented by a dataset, but it is possible to have information relevant to the same topicality spread among multiple datasets. (CDISC Glossary)]
Domain	NCIT_C62289	[An area of knowledge considered as a discreet unit for some purpose.]
CASP6 wt Allele	NCIT_C49557	[Human CASP6 wild-type allele is located within 4q25 and is approximately 15 kb in length. This allele, which encodes caspase-6 protein, plays a role in the cleavage and activation of both lamins and poly (ADP-ribose) polymerase (PARP) during apoptosis. Overexpression of the CASP6 gene promotes programmed cell death.]
CASP6 Gene	NCIT_C28435	[This gene is involved in the execution of apoptosis.]
Submission Domain Abbreviation	NCIT_C49558	[A unique, 2-character domain code used in the regulatory submission process. The domain abbreviation is used consistently throughout the submission, i.e. in the dataset name, as the value of the domain variable within the dataset, and as a prefix for most variable names in the dataset. (CDISC Glossary)]
C5 wt Allele	NCIT_C49551	[Human C5 wild-type allele is located within 9q33-q34 and is approximately 98 kb in length. This allele, which encodes complement C5 protein, is involved in the complement system, inflammatory responses, and histamine release.]
C5 Gene	NCIT_C21538	[Human C5 wild-type allele is located within 9q33-q34 and is approximately 98 kb in length. This allele, which encodes complement C5 protein, is involved in the complement system, inflammatory responses, and histamine release.]
GUCA2A Gene	NCIT_C126515	[This gene plays a role in the positive regulation of intestinal guanylate cyclase.]
Enzyme Induction	NCIT_C41564	[Enzyme Induction involves initiation of function of a biological molecule that possesses catalytic activity.]
CASP2 wt Allele	NCIT_C49552	[Human CASP2 wild-type allele is located within 7q34-q35 and is approximately 19 kb in length. This allele, which encodes caspase-2 protein, plays a role in the activation of caspase-dependent apoptosis.]
CASP2 Gene	NCIT_C26566	[This gene is involved in either the promotion or inhibition of apoptosis depending on both the cell lineage and stage of development.]
GUCA2A wt Allele	NCIT_C126516	[Human GUCA2A wild-type allele is located within 1p35-p34 and is approximately 2 kb in length. This allele, which encodes guanylin protein, is involved in the regulation of intestinal guanylate cyclase activity.]