Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Caspase-Dependent Apoptosis	NCIT_C42785	[Any apoptotic process that involves pathways that activate intracellular proteolytic caspases.]
CARD11 wt Allele	NCIT_C60669	[Human CARD11wild-type allele is located within 7p22 and is 138 kb in length. This allele, which encodes caspase recruitment domain-containing protein 11, plays a role in apoptosis regulation and signal transduction.]
Sialyl Lewis-Keyhole Limpet Hemocyanin Conjugate Vaccine	NCIT_C69000	[A vaccine consisting of the oligosaccharide antigen sialyl Lewis (CA19-9) conjugated to the nonspecific immunomodulator keyhole limpet hemocyanin (KLH), with potential antineoplastic activity. Upon administration, sialyl Lewis-keyhole limpet hemocyanin conjugate vaccine may induce production of IgG and IgM antibodies as well as trigger an antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cells expressing the sialyl Lewis antigen. Sialyl Lewis is a blood group antigen and a tumor-associated antigen associated with epithelial cancers such as breast cancer and various digestive cancers. Sialyl Lewis serves as a ligand for the cytokine-inducible cell adhesion molecule (CAM) E-selectin, an endothelial cell-specific type I transmembrane surface protein, thus facilitating hematogenous metastasis by mediating the adhesion of circulating cancer cells to vascular endothelium.]
Immunoconjugate	NCIT_C1512	[An agent that consists of an immune substance, such as a monoclonal antibody, antigen or an immunoglobulin, and covalently bound to other molecule(s), usually either a toxin, a radioisotope, or a cytotoxic agent. Immunoconjugates allow for specific delivery of certain substances to specific cells or tissues for diagnostic or therapeutic purposes.]
Concentrated Oral Dosage Form	NCIT_C69001	[A concentrate that usually requires dilution prior to oral administration.]
Concentrated Dosage Form	NCIT_C60891	[A solution or suspension composed of active and/or inert ingredient(s) with increased strength in a reduced volume, which is usually diluted prior to administration.]
Oral Dosage Form	NCIT_C42744	[A substance intended for administration through the mouth.]
Compressed Sugar Coated Caplet Dosage Form	NCIT_C69002	[A tablet that has been compacted into capsule shape and covered in sugar.]
Oral Tablet Dosage Form	NCIT_C43243	[A tablet intended for oral administration.]
Tablet 24 Hour Sustained Release Dosage Form	NCIT_C69003	[A tablet designed to release active and/or inert ingredient(s) slowly so as to achieve a constant circulating concentration of the ingredient over a 24 hour time interval.]
Sustained Release Tablet Dosage Form	NCIT_C78751	[A tablet designed to release active and/or inert ingredient(s) slowly so as to achieve a constant circulating concentration of the ingredient over a period of time.]
Tablet 12 Hour Sustained Release Dosage Form	NCIT_C69004	[A tablet designed to release active and/or inert ingredient(s) slowly so as to achieve a constant circulating concentration of the ingredient over a 12 hour time interval.]
Pladienolide Derivative E7107	NCIT_C69005	[A synthetic urethane derivative of pladienolide D with potential antineoplastic activity. Pladienolide derivative E7107 is generated from the 12-membered macrolide pladienolide D, one of several macrolides derived from the bacterium Streptomyces platensis Mer-11107. This agent appears to bind to the 130-kDa subunit 3 (spliceosome-associated protein 130; SAP130) of the splicing factor 3b (SF3b), resulting in inhibition of pre-messenger RNA splicing and the arrest of cell-cycle progression. The splicing factor SF3b is a multiprotein complex integral to the accurate excision of introns from pre-messenger RNA; the subunit SAP130 associates with U2 snRNP and is recruited to prespliceosomal complexes.]
Antineoplastic Antibiotic	NCIT_C259	[An antibiotic, or its derivative, that can kill or inhibit the growth of tumor cells. Antineoplastic antibiotics can interfere with the normal function of cellular nucleic acids and proteins.]
Macrolide	NCIT_C67445	[A term used to describe a chemical structure of a compound containing a large lactone ring, usually with a 14 or 16-membered ring structure. The prototypical compounds within the macrolide class are the erythromycin-based antibiotics; however, many compounds with this chemical structure are being developed for other diseases.]
Tablet Particle Crystal Dosage Form	NCIT_C69006	[A tablet composed of small fragments of singular, repeating units of that are systematically arranged over an evenly spaced lattice.]
Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1	NCIT_C60673	[Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (824 aa, ~92kDa) is encoded by the MALT1 gene. This protein may play a role in NF-kappa-B activation.]
Signaling Protein	NCIT_C18515	[Proteins or peptides that participate in signal transduction processes in the cell.]
MALT1 Gene	NCIT_C60671	[This gene plays a role in signal transduction and in the pathology of mucosa-associated lymphoid tissue lymphomas.]
Chromogranin A Positive Neoplastic Cells Present	NCIT_C60674	[An immunophenotypic test result indicating positive staining of neoplastic cells for chromogranin A.]