Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Pharmacokinetic Concentration Domain	NCIT_C49606	[A subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to pharmacokinetic concentration.]
Subject Characteristics Domain	NCIT_C49610	[A subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to subject characteristics.]
Surgery Domain	NCIT_C49611	[A subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to surgery.]
Skin Test Domain	NCIT_C49612	[A subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to skin test.]
Sleep Polysomnography Domain	NCIT_C49613	[A subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to polysomnography.]
PTP4A3 wt Allele	NCIT_C151405	[Human PTP4A3 wild-type allele is located in the vicinity of 8q24.3 and is approximately 40 kb in length. This allele, which encodes protein tyrosine phosphatase type IVA 3 protein, is involved in protein phosphatase activity, progression of the cell cycle and promotion of cell proliferation and cell motility. Aberrant expression of the gene is associated with tumor metastasis.]
PTP4A3 Gene	NCIT_C151404	[This gene plays a role in cell cycle progression, cell proliferation, cell motility and cellular invasiveness.]
PTP4A Family Signaling Pathway	NCIT_C91677
Protein Tyrosine Phosphatase Type IVA 3	NCIT_C151406	[Protein tyrosine phosphatase type IVA 3 (173 aa, ~20 kDa) is encoded by the human PTP4A3 gene. This protein plays a role in tyrosine phosphatase activity that promotes cell cycle progression.]
Non-Receptor Type Protein Tyrosine Phosphatase	NCIT_C106408	[A group of cytosolic enzymes that specifically remove tyrosine-bound phosphate groups from many phosphoproteins, including many enzymes phosphorylated by a tyrosine kinase. These proteins play a role in the modulation of tyrosine phosphorylation and dephosphorylation in cellular signaling pathways.]
Flt3/MerTK Inhibitor MRX-2843	NCIT_C151407	[An orally bioavailable inhibitor of two receptor tyrosine kinases (RTKs), FMS-like tyrosine kinase-3 (Flt3; CD135; fetal liver kinase-2; Flk2) and tyrosine-protein kinase Mer (MerTK; proto-oncogene c-Mer; Mer), with potential antineoplastic activity. Upon administration, MRX-2843 targets and binds to both Flt3 and MerTK. This prevents ligand-dependent phosphorylation and activation of Flt3 and MerTK, which inhibits the activation of their downstream signaling pathways. This induces apoptosis and inhibits proliferation of Flt3- and/or MerTK-overexpressing tumor cells. Flt3 and MerTK, are overexpressed in certain tumor cell types and play key roles in tumor cell proliferation and survival.]
FLT3 Inhibitor	NCIT_C124800	[Any drug or substance that inhibits the activity of receptor-type tyrosine-protein kinase FLT3 protein.]
Beyond	NCIT_C151408	[Past a place or outside an area.]
High Grade Fallopian Tube Serous Adenocarcinoma	NCIT_C126456	[A rapidly growing serous adenocarcinoma that arises from the fallopian tube. It is characterized by the presence of high grade cytologic features and frequent mitotic figures.]
Fallopian Tube Serous Adenocarcinoma	NCIT_C40099	[A serous adenocarcinoma that arises from the fallopian tube. It is usually a high grade invasive adenocarcinoma.]
Low Grade Fallopian Tube Serous Adenocarcinoma	NCIT_C126457	[A slow-growing serous adenocarcinoma that arises from the fallopian tube. It is characterized by the presence of low grade cytologic features and infrequent mitotic figures.]
PTPN21 Gene	NCIT_C126458	[This gene plays a role in peptidyl-tyrosine dephosphorylation.]
Non-Receptor Protein Tyrosine Phosphatase Gene	NCIT_C25972	[Non-Receptor Protein Tyrosine Phosphatase Genes encode Non-Receptor Protein Tyrosine Phosphatases, one of the two main categories (soluble and transmembrane receptor) of enzymes that catalyze removal of a tyrosine-attached phosphate group and are important in control of cell growth, proliferation, differentiation, and transformation. Two cysteines in the catalytic domain (one absolutely required for activity) are generally conserved; other conserved residues in the vicinity are important. (NCI)]
PTPN21 wt Allele	NCIT_C126459	[Human PTPN21 wild-type allele is located in the vicinity of 14q31.3 and is approximately 89 kb in length. This allele, which encodes tyrosine-protein phosphatase non-receptor type 21 protein, is involved in protein dephosphorylation.]
Nearly Every Day for 2 Weeks	NCIT_C126452	[A response indicating that something happens or happened nearly every day for two weeks.]