Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
PRRC1 Gene	NCIT_C126635	[This gene has no known function.]
5q23.2	NCIT_C25081	[A chromosome band present on 5q]
Beats per Minute	NCIT_C49673	[The number of heartbeats measured per minute time.]
Units for Vital Signs Results	NCIT_C49675	[The unit used to record and describe the result of a test investigating a vital sign.]
Protein PRRC1	NCIT_C126637	[Protein PRRC1 (445 aa, ~47 kDa) is encoded by the human PRRC1 gene. The function of this protein is unknown.]
Breaths per Minute	NCIT_C49674	[The number of breaths (inhalation and exhalation) taken per minute time.]
Imipramine Blue	NCIT_C126638	[A triphenylmethane-based dye and an inhibitor of nicotinamide adenine dinucleotide phosphate (NADP+) oxidase 4 (NOX4), with potential anti-invasive and anti-oxidative activities. Upon administration, imipramine blue (IB) inhibits the activity of NOX4 and prevents NOX4-mediated cell signaling. This prevents the formation of NOX4-mediated reactive oxygen species (ROS), abrogates the ROS-induced inhibition of protein tyrosine phosphatase (PTP) activation, and induces both G2/M cell cycle arrest and apoptosis. NOX4, an enzyme belonging to the NOX family of proteins, promotes the production of ROS and plays a key role in the suppression of PTP activation; it is upregulated in a variety of cancers.]
Autologous Anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ Central Memory T-lymphocytes JCAR014	NCIT_C126639	[A defined preparation of CD4+ and CD8+ central memory (CM) autologous T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) containing an anti-CD19 single chain variable fragment (scFv) fused to the signaling domains of CD28, 4-1BB (CD137), the zeta chain of the TCR/CD3 complex (CD3-zeta), and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+CM T-lymphocytes JCAR014 are directed to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of those cells through a cetuximab-induced antibody dependent cellular cytotoxicity (ADCC) response. The 4-1BB costimulatory signaling domain enhances both proliferation of T-cells and antitumor activity.]
ACTN4 Gene	NCIT_C126632	[This gene plays a role in the binding of actin to other cellular structures.]
ACTN4 wt Allele	NCIT_C126633	[Human ACTN4 wild-type allele is located in the vicinity of 19q13 and is approximately 84 kb in length. This allele, which encodes alpha-actinin-4 protein, is involved in crosslinking actin to other cellular proteins. Mutations in this gene are associated with focal segmental glomerulosclerosis.]
Millimeter of Mercury	NCIT_C49670	[A non-SI unit of pressure equal to 133,332 Pa or 1.316E10-3 standard atmosphere. Use of this unit is generally deprecated by ISO and IUPAC.]
Alpha-Actinin-4	NCIT_C126634	[Alpha-actinin-4 (911 aa, ~105 kDa) is encoded by the human ACTN4 gene. This protein plays a role in actin crosslinking.]
Kilogram per Square Meter	NCIT_C49671	[The SI derived unit of spread rate of a substance by mass, used also as a measure of area density and as a dose calculation unit.]
Hemorrhagic Shock	NCIT_C35017	[Hypoperfusion of body tissues due to acute blood loss, resulting in cellular injury and vital organ dysfunction.]
Septic Shock	NCIT_C35018	[A state of acute circulatory failure characterized by persistent arterial hypotension despite adequate fluid resuscitation or by tissue hypoperfusion unexplained by other causes.]
Surgical Shock	NCIT_C35019	[Hypoperfusion of body tissues occurring during or after a surgical procedure, and resulting in cellular injury and vital organ dysfunction.]
BTBD18 wt Allele	NCIT_C126630	[Human BTBD18 wild-type allele is located in the vicinity of 11q12.1 and is approximately 9 kb in length. This allele, which encodes BTB/POZ domain-containing protein 18, may play a role in the ubiquitination of proteins.]
BTBD18 Gene	NCIT_C126629	[This gene may be involved in protein ubiquitination.]
11q12.1	NCIT_C26577	[A chromosome band present on 11q]
BTB/POZ Domain-Containing Protein 18	NCIT_C126631	[BTB/POZ domain-containing protein 18 (712 aa, ~78 kDa) is encoded by the human BTBD18 gene. This protein may be involved in the regulation of ubiquitination.]