Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Chromatin	NCIT_C13201	[The genetic material of the nucleus, consisting of deoxyribonucleoprotein, which occurs in two forms during the phase between mitotic divisions: 1) as heterochromatin, seen as condensed, readily stainable clumps; 2) as euchromatin, dispersed lightly staining or nonstaining material. During mitotic division the chromatin condenses into chromosomes.]
PDS5A Gene	NCIT_C126608	[This gene plays a role in the regulation of both mitosis and cell proliferation.]
Mitotic Sister Chromatid Cohesion	NCIT_C28752	[The faithful segregation of genetic information requires highly orchestrated changes of chromosome structure during the mitotic cell cycle. The linkage between duplicated sister DNAs is established during S phase and maintained throughout G2 phase (cohesion). In early mitosis, dramatic structural changes occur to produce metaphase chromosomes, each consisting of a pair of compacted sister chromatids (condensation). At anaphase onset, a signal is produced to disrupt the linkage between sister chromatids (separation), allowing them to be pulled apart to opposite poles of the cell. (from PubMed 10966455)]
Trial Summary Parameter	NCIT_C49691	[Individual characteristics of a clinical trial, e.g. description of trial design, trial blinding schema, and primary objective of trial.]
CEP170B Gene	NCIT_C126611	[This gene may be involved in microtubule organization.]
Planned Subject Number	NCIT_C49692	[The number of subjects entered in a clinical trial.]
CEP170B wt Allele	NCIT_C126612	[Human CEP170B wild-type allele is located in the vicinity of 14q32.33 and is approximately 31 kb in length. This allele, which encodes centrosomal protein of 170 kDa protein B, may play a role in microtubule organization.]
14q32.33	NCIT_C24953	[A chromosome band present on 14q]
Planned Minimum Age of Subjects	NCIT_C49693	[The anticipated minimum age of the subjects to be entered in a clinical trial.]
Centrosomal Protein of 170 kDa Protein B	NCIT_C126613	[Centrosomal protein of 170 kDa protein B (1589 aa, ~172 kDa) is encoded by the human CEP170B gene. This protein may be involved in microtubule dynamics.]
FHA Domain	NCIT_C13945	[The FHA (Forkhead-Associated) domain is a phosphopeptide recognition domain found in many regulatory proteins. It displays specificity for phosphothreonine-containing epitopes but will also recognize phosphotyrosine with relatively high affinity. It spans approximately 80-100 amino acid residues folded into an 11-stranded sandwich, which sometimes contain small helical insertions between the loops connecting the strands. To date, genes encoding FHA-containing proteins have been identified in eubacterial and eukaryotic but not aracheal genomes. The domain is present in a diverse range of proteins, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins and metabolic enzymes which partake in many different cellular processes. DNA repair, signal transduction, vesicular transport and protein degradation are just a few examples.]
Microtubule	NCIT_C13256	[Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. (from LocusLink)]
Nucleated Red Blood Cell to Erythrocyte Ratio Measurement	NCIT_C74647	[The determination of the ratio of nucleated red blood cells compared to erythrocytes present in a sample. The measurement may be expressed as a ratio or percentage.]
Ulcerative Stomatitis	NCIT_C35039	[Inflammation of the mouth mucosa associated with the presence of ulcers.]
Stomatitis	NCIT_C26887	[Inflammation of the oral mucosa due to local or systemic factors.]
Plasmacytoid Lymphocyte to Lymphocyte Ratio Measurement	NCIT_C74648	[The determination of the ratio of plasmacytoid lymphocytes compared to all lymphocytes present in a sample. The measurement may be expressed as a ratio or percentage.]
Poikilocyte to Erythrocyte Ratio Measurement	NCIT_C74649	[The determination of the ratio of poikilocytes compared to all erythrocytes present in a sample. The measurement may be expressed as a ratio or percentage.]
Tabes Dorsalis	NCIT_C35057	[A form of neurosyphilis characterized by slowly progressive degeneration of the spinal cord. Signs and symptoms include pain, ataxia, loss of coordination, personality changes, blindness, urinary incontinence, dementia, and degeneration of the joints.]
Neurosyphilis	NCIT_C84935	[Infection of the brain or spinal cord by Treponema pallidum. It occurs many years following the original infection which remained untreated. Signs and symptoms include abnormal gait, blindness, depression, paralysis, seizures and dementia.]
Grade 5 Opportunistic Infection, CTCAE	NCIT_C60013