Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
ADAMTS9 wt Allele	NCIT_C49725	[Human ADAMTS9 wild-type allele is located within 3p14.3-p14.2 and is approximately 172 kb in length. This allele, which encodes ADAMTS-9, is involved in the proteolytic cleavage of large aggregating proteoglycans.]
CCL19 wt Allele	NCIT_C49726	[Human CCL19 wild-type allele is located within 9p13 and is approximately 2 kb in length. This allele, which encodes C-C motif chemokine 19 protein, plays a role in thymic T cell trafficking and in B and T cell migration.]
CCL19 Gene	NCIT_C24773	[This gene is involved in inflammatory processes.]
MME wt Allele	NCIT_C49727	[Human MME wild-type allele is located within 3q25.1-q25.2 and is approximately 104 kb in length. This allele, which encodes neprilysin protein, plays a role in the destruction of polypeptides containing up to 30 amino acids. An allelic variant of the MME gene is associated with fetomaternal alloimmunisation with antenatal glomerulopathies and membranous glomerulonephritis (FMAIG) as well as with renal failure in early adulthood. The MME gene is also associated with susceptibility to late-onset Alzheimer's disease.]
MME Gene	NCIT_C24607	[This gene is involved in the inactivation of peptide hormones.]
MMP1 wt Allele	NCIT_C49731	[Human MMP1 wild-type allele is located in the vicinity of 11q22.3 and is approximately 8 kb in length. This allele, which encodes interstitial collagenase protein, is involved in the breakdown of the extracellular matrix via the degradation of interstitial collagens (types I, II and III). The MMP1 gene is associated with neoplasm invasiveness.]
MMP1 Gene	NCIT_C41043	[This gene plays a role in cell migration, inflammation and the regulation of extracellular matrix remodeling.]
MMP2 wt Allele	NCIT_C49732	[Human MMP2 wild-type allele is located within 16q13-q21 and is approximately 27 kb in length. This allele, which encodes 72 kDa type IV collagenase protein, is involved in the breakdown of the extracellular matrix via the degradation of type IV collagen, the major structural component of basement membranes. The MMP2 gene is associated with neoplasm invasiveness.]
MMP2 Gene	NCIT_C26514	[This gene is involved in angiogenesis, inflammation and the regulation of extracellular matrix remodeling.]
MMP3 wt Allele	NCIT_C49733	[Human MMP3 wild-type allele is located in the vicinity of 11q22.3 and is approximately 8 kb in length. This allele, which encodes stromelysin-1 protein, plays a role in the regulation of matrix remodeling via the activation of matrix metalloproteinase precursors. It is also involved in the inhibition of breast tumor cell metastasis through the degradation of plasminogen and laminin. The MMP3 gene is associated with osteoarthritis, rheumatoid arthritis and neoplasm invasiveness.]
MMP3 Gene	NCIT_C26510	[This gene plays a role in wound repair and the regulation of extracellular matrix remodeling.]
MMP8 wt Allele	NCIT_C49734	[Human MMP8 wild-type allele is located in the vicinity of 11q22.3 and is approximately 12 kb in length. This allele, which encodes neutrophil collagenase protein, is involved in the regulation of matrix remodeling via the degradation of fibrillar collagens (types I, II and III).]
MMP8 Gene	NCIT_C41045	[This gene is involved in proteolysis and the regulation of matrix remodeling.]
MMP14 wt Allele	NCIT_C49730	[Human MMP14 wild-type allele is located within 14q11-q12 and is approximately 11 kb in length. This allele, which encodes matrix metalloproteinase-14, plays a role in the activation of progelatinase A. The MMP14 gene is associated with the metastasis of several types of cancer including breast, gastric and laryngeal cancers.]
MMP14 Gene	NCIT_C41049	[This gene is involved in cell migration and motility.]
BOK Gene	NCIT_C126577	[This gene plays a role in the activation of apoptosis.]
BOK wt Allele	NCIT_C126578	[Human BOK wild-type allele is located in the vicinity of 2q37.3 and is approximately 16 kb in length. This allele, which encodes Bcl-2-related ovarian killer protein, is involved in the induction of apoptosis.]
Bcl-2-Related Ovarian Killer Protein	NCIT_C126579	[Bcl-2-related ovarian killer protein (212 aa, ~23 kDa) is encoded by the human BOK gene. This protein plays a role in the positive regulation of apoptosis.]
NUAK Family SNF1-Like Kinase 1	NCIT_C126573	[NUAK family SNF1-like kinase 1 (661 aa, ~74 kDa) is encoded by the human NUAK1 gene. This protein plays a role in protein phosphorylation, which regulates DNA damage response, apoptosis, cell adhesion, cellular senescence, and cell proliferation.]
NELFB Gene	NCIT_C126574	[This gene is involved in pausing transcriptional elongation.]