Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Bispecific Antibody 520C9XH22/Interferon Gamma	NCIT_C15586
Bispecific Antibody MDX-H210	NCIT_C1578	[A humanized bivalent antibody directed against both cytotoxic effector cells expressing Fc gamma receptor type I (Fc gammaRI, or CD64) and HER2/neu-overexpressing tumor cells with potential antineoplastic activity. Bispecific antibody MDX-H210 was constructed by chemically linking Fab' fragments of the anti-HER2/neu-specific monoclonal antibody 520C9 and the Fab' fragments of the anti-Fc gammaRI-specific monoclonal antibody H22. This agent selectively binds to both HER2/neu-expressing tumor cells and Fc gammaRI-expressing cytotoxic effector cells, which may trigger antibody-dependent cell-mediated cytotoxicity (ADCC) and cell lysis of HER2/neu-expressing tumor cells. While HER2/neu is overexpressed in a variety of epithelial malignancies, expression of Fc gammaRI is primarily found in cytotoxic immune cells, including monocytes, macrophages, and cytokine-activated polymorphonuclear (PMN) cells.]
Recombinant Interferon Gamma	NCIT_C583	[A recombinant therapeutic agent which is chemically identical to or similar to the endogenous lymphokine interferon gamma (IFN-gamma) with antineoplastic, immunoregulatory, and antiviral activities. Therapeutic IFN-gamma binds to and activates the cell-surface IFN-gamma receptor, stimulating antibody-dependent cytotoxicity and enhances natural killer cell attachment to tumor cells. This agent also activates caspases, thereby inducing apoptosis in malignant cells. (NCI04)]
Bone Marrow Ablation with Stem Cell Support	NCIT_C15587	[Bone marrow ablation followed by replacement of stem cells in the circulating blood to help the bone marrow recover and continue producing healthy blood cells.]
interleukin-6/sargramostim	NCIT_C15588
Melphalan/Tumor Necrosis Factor	NCIT_C15589
Opioid Receptor Binding	NCIT_C40525	[A process that involves the non-covalent binding of opioids to one of four opioid receptors. These interactions are involved in mediation of analgesia, euphoria, and physical dependence to opioids.]
Osmotic Activity	NCIT_C40526	[Osmotic Activity is a passive process in which water diffuses across a cell membrane in response to a concentration gradient.]
Parathyroid Hormone Receptor Binding	NCIT_C40527	[A process that involves the non-covalent binding of parathyroid hormone to one of the parathyroid hormone receptors. This interaction plays a role in signal transduction, which mediates the maintenance of calcium and magnesium homeostasis.]
Pituitary Hormone Receptor Binding	NCIT_C40528	[A process that involves the binding of any member of the group of pituitary hormones, including growth hormone, thyroid stimulating hormone, adrenocorticotropic hormone, follicle-stimulating hormone, luteinizing hormone and prolactin, to their respective receptors. These interactions are essential for glandular development and homeostasis.]
Plasminogen Activator Interaction	NCIT_C40529	[Plasminogen Activator Interaction involves temporary non-covalent binding through intermolecular physical forces of attraction with heterogeneous group of widely expressed lysosomal and secreted serine proteases having fibrin-binding activity that convert plasminogen to fibrinolytic plasmin. Inhibited by PAI-1, encoded by the PLAT Gene (Peptidase S1 Family), and cleaved by plasmin, tissue kallikrein, or factor XA to disulfide-linked A/B chains, tissue-type plasminogen activator plays a role in cell migration and tissue remodeling.]
FAMS - Feel Motivated to Do Things	NCIT_C112578	[Functional Assessment of Multiple Sclerosis (FAMS) General Contentment: I feel motivated to do things.]
FAMS - Have a Lack of Energy	NCIT_C112579	[Functional Assessment of Multiple Sclerosis (FAMS) Thinking and Fatigue: I have a lack of energy.]
FAMS - Enjoying Things I Usually Do for Fun	NCIT_C112574	[Functional Assessment of Multiple Sclerosis (FAMS) General Contentment: I am enjoying the things I usually do for fun.]
FAMS - Content With Quality of My Life Now	NCIT_C112575	[Functional Assessment of Multiple Sclerosis (FAMS) General Contentment: I am content with the quality of my life right now.]
FAMS - I Am Frustrated by My Condition	NCIT_C112576	[Functional Assessment of Multiple Sclerosis (FAMS) General Contentment: I am frustrated by my condition.]
FAMS - Feel Sense of Purpose in My Life	NCIT_C112577	[Functional Assessment of Multiple Sclerosis (FAMS) General Contentment: I feel a sense of purpose in my life.]
Muscarinic Receptor Binding	NCIT_C40521	[A process that involves the non-covalent interaction of acetylcholine with one of the five muscarinic receptors. These interactions play a role in signal transduction, which influences bodily functions including salivation, lacrimation, urination, digestion and defecation.]
FAMS - I Feel Useless	NCIT_C112570	[Functional Assessment of Multiple Sclerosis (FAMS) Emotional Well-Being: I feel useless.]
FAMS - Feel Overwhelmed by My Condition	NCIT_C112571	[Functional Assessment of Multiple Sclerosis (FAMS) Emotional Well-Being: I feel overwhelmed by my condition.]