Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Clino-San Vaginal Lubricant	NCIT_C74018	[A vaginal lubricant formulated as a topical gel used to prevent and treat vaginal dryness. With a pH similar to that of normal vaginal discharge, Clino-San vaginal lubricant may reduce dryness, pain and irritation often caused by insufficient vaginal discharge due to atrophy of the vulvovaginal mucosa.]
Copper Cu 61-ATSM	NCIT_C74019	[A lipophilic copper(II)bis(thiosemicarbazone) labeled with the positron-emitting isotope (61)Cu with hypoxia-selective and radioisotopic activities. With a high membrane permeability and redox potential, (61)Cu-ATSM easily enters and selectively resides in hypoxic cells. The extent of (61)Cu-ATSM retention in tissue is inversely related to the state of tissue oxygenation allowing the quantitation of tissue hypoxia with positron emission tomography (PET).]
HmmPfam Algorithm	NCIT_C49045	[A program that searches Hidden Markov Models from the PFAM database for significantly similar sequence matches to the input protein sequence.]
Rivoceranib Mesylate	NCIT_C74012	[The mesylate salt of rivoceranib, an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. Rivoceranib selectively binds to and inhibits vascular endothelial growth factor receptor 2, which may inhibit VEGF-stimulated endothelial cell migration and proliferation and decrease tumor microvessel density. In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases.]
Cancer Bioinformatics Grid	NCIT_C49046	[A voluntary network or grid connecting individuals and institutions to enable the sharing of data and tools, creating a World Wide Web of cancer research. The goal is to speed the delivery of innovative approaches for the prevention and treatment of cancer. The infrastructure and tools created by caBIG also have broad utility outside the cancer community. caBIG is being developed under the leadership of the National Cancer Institute's Center for Bioinformatics.]
Arnebia Indigo Jade Pearl Topical Cream	NCIT_C74013	[A proprietary multiherbal topical cream based on Chinese herbal medicine with potential antineoplastic, antiviral, antibacterial and immunostimulatory activities. Arnebia Indigo Jade Pearl topical cream contains 12 ingredients including 9 herbs infused in sesame oil, with an additional three powdered ingredients and beeswax added to the infused oil to create the salve. The purported mechanism(s) of action is unclear due to the complexity of the herbal mixture.]
Cancer Imaging Program	NCIT_C49047	[The mission of the Cancer Imaging Program, National Cancer Institute, is to promote and support Cancer-related basic, translational and clinical research in imaging sciences and technology, and integration and application of these imaging discoveries and developments to the understanding of cancer biology and to the clinical management of cancer and cancer risk.]
Component of the National Cancer Institute	NCIT_C20161
Aurora Kinase Inhibitor BI 811283	NCIT_C74014	[A small molecule inhibitor of the serine/threonine protein kinase Aurora kinase with potential antineoplastic activity. Aurora kinase inhibitor BI 811283 binds to and inhibits Aurora kinases, resulting in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation.]
Aurora Kinase Inhibitor	NCIT_C62556	[Any substance that inhibits Aurora kinase, a serine/threonine kinase that is involved in mitotic spindle morphology, centrosome function, chromatid separation, and cytokinesis. Aurora kinases are overexpressed in a variety of human cancers.]
Test Context	NCIT_C49048	[A user environment where a curator may explore curation techniques or illustrate options without making the work products available for general use.]
Autologous Dendritic Cell-Adenovirus CCL21 Vaccine	NCIT_C74015	[A cancer vaccine comprised of autologous dendritic cells (DCs) that have been transduced ex vivo with an adenoviral vector containing the CCL21 gene with potential immunostimulatory and antineoplastic activities. Upon intratumoral administration, autologous dendritic cell-adenovirus CCL21 vaccine expresses the chemokine CCL21, which may induce an antitumoral cytotoxic immune response in the tumor microenvironment. CCL21 [chemokine (C-C motif) ligand 21] has been shown to attract antigen presenting cells (APCs), like leukocytes and DCs, and natural killer (NK) cells and their T-cell effectors to induce a cytotoxic immune response.]
gp100:280-288(288V) Peptide Vaccine	NCIT_C49042	[A peptide vaccine consisting of the amino acids 280 through 288 of the melanoma antigen glycoprotein 100 (gp100) with potential antineoplastic activity. gp100:280-288(288V) peptide has a valine substitution at amino acid position 288 to improve immunogenicity. Vaccination with gp100:280-288(288V) peptide may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for the gp100 antigen, resulting in decreased tumor growth.]
Melanoma of the Conjunctiva cT2c TNM Finding v7	NCIT_C88650	[Any caruncular, less than or equal to 1 quadrant. (from AJCC 7th Ed.)]
SignalP Algorithm	NCIT_C49043	[An algorithm that predicts the presence and location of signal peptide cleavage sites in amino acid sequences. It incorporates a prediction of cleavage sites and a signal peptide/non-signal peptide prediction based on a combination of several artificial neural networks and hidden Markov models.]
Melanoma of the Conjunctiva cT2d TNM Finding v7	NCIT_C88651	[Any caruncular, greater than 1 quadrant. (from AJCC 7th Ed.)]
COILS Program	NCIT_C49044	[A program that compares a sequence to a database of known parallel two-stranded coiled-coils and derives a similarity score. By comparing this score to the distribution of scores in globular and coiled-coil proteins, the program then calculates the probability that the sequence will adopt a coiled-coil conformation.]
FFAS Algorithm	NCIT_C49040	[A profile-profile alignment algorithm that make structural predictions using sequence information.]
Melanoma of the Conjunctiva pM1 TNM Finding v7	NCIT_C88635	[Melanoma of the conjunctiva with distant metastasis. (from AJCC 7th Ed.)]
Melanoma of the Conjunctiva Pathologic Distant Metastasis TNM Finding v7	NCIT_C88634	[A pathologic finding about one or more characteristics of melanoma of the conjunctiva, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. There is no pathologic M0 for melanoma of the conjunctiva. (from AJCC 7th Ed.)]