Terminology Service < Semantic Lookup Platform

All terms in NCIT

Label	Id	Description
Melanoma of the Ciliary Body and Choroid pT3 TNM Finding v7	NCIT_C88696	[Tumor size category 3. (from AJCC 7th Ed.)]
Melanoma of the Ciliary Body and Choroid pT3b TNM Finding v7	NCIT_C88698	[Tumor size category 3 with ciliary body involvement. (from AJCC 7th Ed.)]
Melanoma of the Ciliary Body and Choroid pT3c TNM Finding v7	NCIT_C88699	[Tumor size category 3 without ciliary body involvement but with extraocular extension less than or equal to 5 mm in diameter. (from AJCC 7th Ed.)]
Iodine I 131-6-Beta-Iodomethyl-19-Norcholesterol	NCIT_C74052	[A radioiodine-labeled cholesterol analogue with radioisotopic activity. Iodine 131-I-6-beta-iodomethyl-19-norcholesterol accumulates in tissues where steroid hormones are produced, including the adrenal cortex and, to a lesser extent, the ovaries and the testes. After binding to low-density lipoprotein (LDL) receptors in the adrenal cortex, this agent is internalized, permitting scintigraphic localization of areas of adrenocortical glucocorticoid, mineralocorticoid and androgen secretion, and the scintigraphic assessment of adrenocortical function.]
Lactobacillus Fermented Extract	NCIT_C74053	[A proprietary dietary supplement. Lactobacillus fermented extract is made from soymilk fermented by several strains of lactobacillus and yeast via a symbiotic co-culturing technology. The composition of the agent includes amino acids, vitamins, minerals, fatty acids, isoflavones, and saponins. Lactobacillus fermented extract may support healthy intestinal function.]
Liposomal MnSOD Plasmid	NCIT_C74054	[A plasmid DNA encoding human manganese superoxide dismutase (MnSOD) and liposomally encapsulated with potential chemoprotective activity. When administered orally and localizing in the esophagus, MnSOD-plasmid liposomes express MnSOD, which scavenges reactive oxygen species (ROS); MnSOD scavenging of ROS may result in a reduction in ROS-mediated lipid peroxidation, apoptosis, and micro-ulceration in the epithelial lining of the esophagus.]
Gene Transfer or Gene Delivery Agent	NCIT_C61199	[Genetic engineered recombinant products, including viral or non-viral based system that can be used to transfer genetic materials of interest into cells for either research or clinical purpose.]
Live-Attenuated Listeria Encoding Human Mesothelin Vaccine CRS-207	NCIT_C74055	[A recombinant Listeria-based cancer vaccine containing a live-attenuated strain of the facultative intracellular bacterium Listeria monocytogenes (Lm) expressing human mesothelin with potential immunostimulatory and antineoplastic activities. Upon administration of this vaccine, Listeria invade professional phagocytes within the immune system and express mesothelin, which may activate a cytotoxic T-lymphocyte (CTL) response against mesothelin-expressing tumor cells, resulting in tumor cell lysis. In addition, the Listeria vector itself may induce a potent innate and adaptive immunity unrelated to mesothelin expression. Mesothelin is a cell surface glycoprotein involved in cell adhesion and is overexpressed in many epithelial-derived cancers, including pancreatic, ovarian and lung cancers, and malignant mesotheliomas.]
Iodine I 124-Iodo-Azomycin Galactopyranoside	NCIT_C74050	[A diagnostic radiopharmaceutical comprised of iodo-azomycin galactopyranoside (IAZGP) labeled with the positron-emitting radioisotope iodine I 124 and used as an imaging agent. Iodine I 124 iodo-azomycin galactopyranoside (I-124 IAZGP) is reduced under hypoxic conditions, covalently binding to macromolecules in hypoxic cells. After incorporation into hypoxic tumor cell DNA, I-124 IAZGP can be localized and quantified using positron emission tomography (PET), allowing a quantitative assessment of hypoxic tumor burden. IAZGP appears to have a higher water solubility and faster clearance from normal tissue than traditional imidazole tracers.]
Iodine I 125-Anti-EGFR-425 Monoclonal Antibody	NCIT_C74051	[A radioimmunoconjugate consisting of a murine IgG2a monoclonal antibody directed against the human epidermal growth factor receptor (EGFR) labeled with iodine I 125 with potential antineoplastic activity. Iodine I 125 anti-EGFR-425 monoclonal antibody binds specifically to the epidermal growth factor receptor (EGFR). Upon binding to EGFR-expressing tumor cells, this agent is internalized, selectively delivering a potentially cytotoxic dose of gamma radiation. EGFR is a receptor tyrosine kinase that may be overexpressed on the cell surfaces of various solid tumors.]
Iobenguane Sulfate I-123	NCIT_C74049	[The neurotransmitter analogue 3-nitrobenzylguanidine conjugated to iodine I 123 and used as a gamma-emitting imaging agent. The adrenergic tissue uptake and storage of I-123 metaiodobenzylguanidine (I-123 MIBG) mimics that of norepinephrine (NE). The distribution of this agent enables the scintigraphic imaging of neural crest tumors, such as neuroblastoma and pheochromocytoma.]
Indibulin	NCIT_C74045
Indium In 111 Bevacizumab	NCIT_C74046	[A radioimmunoconjugate comprised of the recombinant humanized monoclonal antibody bevacizumab conjugated with the gamma-emitting radioisotope indium In 111. Indium I 111 bevacizumab binds to vascular endothelial growth factor (VEGF), allowing the detection of VEGF distribution using gamma scintigraphy.]
Indium In 111 Girentuximab	NCIT_C74047	[A radioimmunoconjugate comprised of the chimeric monoclonal antibody girentuximab conjugated with the gamma-emitting radioisotope indium In 111. Indium In 111 girentuximab binds to G250, allowing the localization of G250-expressing tumor cells using gamma scintigraphy. Found in the majority of renal cell carcinomas (RCCs), G250 or carbonic anhydrase isozyme IX (CA IX) is a cell surface tumor-associated antigen (TAA).]
Indium In 111 Monoclonal Antibody HuPAM4	NCIT_C74048	[The humanized monoclonal antibody huPAM4, directed against the pancreatic cancer antigen MUC-1 and labeled with the gamma-emitting radioisotope indium In 111, with radioisotopic and antibody activities. Upon administration, indium In 111 monoclonal antibody huPAM4 may bind to MUC-1-positive tumor cells, allowing radioimmunolocalization with gamma scintigraphy. Overexpressed by many tumor cell types, MUC-1 antigen, a mammary-type apomucin, is a high-molecular-weight transmembrane glycoprotein.]
Alvimopan	NCIT_C49096	[A synthetic trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine with peripherally selective opioid mu receptor antagonist activity. Alvimopan is a selective and competitive antagonist at mu-opioid receptors, found in myenteric and submucosal neurons and the immune cells of the lamina propria in the human gut. Upon administration, this agent binds to mu-opioid receptors in the gut, thereby reversing opioid-related disturbances in gut motility. Alvimopan is approximately three to nine times more potent than naloxone.]
Opiate Antagonist	NCIT_C681	[Any agent that binds to or interferes with binding to any of the opioid receptor subtypes, thereby blocking the actions of opioid agonists.]
Wide Vessel-Like Spaces Formation	NCIT_C49097
Melanin-Pigmented Dendritic Cells Present	NCIT_C49098
Blood Oxygen Level-Dependent Functional MRI	NCIT_C49099	[A magnetic resonance imaging technique that uses the difference between the magnetic signals of hemoglobin when it is carrying oxygen (oxyhemoglobin) and when it is not carrying oxygen (deoxyhemoglobin) to detect metabolic activity, and hence neurologic activity, in the brain.]